Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 115 for “"SCID"”.
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Charakterisierung humaner kurz-zeitrepopulierender Blutstammzellen im NOD/SCID-ß2m-/- Xenotransplantationsmodell
… nachgewiesen werden. Mit Hilfe des NOD/SCID-ß2m-/- Maus-Xenotransplantationssystems können zwei verschiedene Klassen humaner STRC quantifiziert werden: myeloisch determinierte (STRC-M) und lymphatisch-myeloisch determinierte STRC (STRC-ML). <br>a)Im Rahmen dieser Arbeit wurde der …
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Insights into the clonal inventory of gene corrected human SCID-XI hematopoiesis
… on DNA material from patient No. 4 of the French SCID-X1 gene therapy clinical trial, who has developed a T-cell leukemia like disease at 31 months after gene therapy. Multiple integration sites could be identified in posttransplantation samples, demonstrating multiple transduced clones …
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Characterization of the genetic defects in patients with Severe Combined Immunodeficiency (SCID)
… ascribed to severe combined immunodeficiency (SCID). The aim of the project was to do (1) mutational analysis on the affected families, (2) on the basis of the mutational analysis, offer genetic counselling, (3) do carrier screening tests on the families studied, and (4) to try and find a …
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Untersuchungen HLA-Klasse II-assoziierter, T-zellvermittelter Autoimmunität im humanisierten SCID-Mausmodell des Pemphigus vulgaris
… activation in an in vivo model. The humanized SCID mouse model allows the adoptive transfer of human peripheral blood lymphocytes (PBL) to establish a functional human immune system within the murine organism. PBL from a patient with active PV disease, from a HLA-homologous healthy control and …
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Adhäsions- und Nidationsprophylaxe nach i.p.-Implantation von SCOV3.ip-Zellen in SCID-Mäuse mittels Icodextrin, Hyaluronsäure und physiologischer NaCl-Lösung im Vergleich
… after surgery of ovarian carcinoma. Forty SCID-mice (NOD.CB17-Prkdcscid/J) were enclosed into the study and randomly assigned to four experimental groups of ten animals each: group 1: Icodextrin (Adept®), group 2: hyaluronic acid (Hyalobarrier®-Gel), group 3: physiologic saline, group 4: …
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Untersuchung humaner Stammzellen aus dem adulten Knochenmark und der fetalen Leber
… In Xenotransplantations-experimenten mit NOD/SCID-Mäusen wurde verglichen, ob CD34-transduzierte MSC und nicht transduzierte MSC die Fähigkeit besitzen, einen subletal bestrahlten Organismus zu repopulieren. Bei zwei von insgesamt elf transplantierten Mäusen konnte humanes Engraftment …
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The Utility of Depression Screening Measures After Traumatic Brain Injury
… Interview for DSM-IV TR Axis I Disorders (SCID) in an outpatient neuropsychology clinic at a university medical center, outpatient physical medicine and rehabilitation clinics, and a long-term specialized living assistance program. Screening measure results were compared with SCID results …
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Essays on corporate governance and executive compensation
… novel measure is the Slice of CEO Inside Debt (SCID) – the frac- tion of the aggregate deferred compensation (inside debt) of the top-five executive team captured by the CEO. The effects of total deferred compensation account balances, firm contributions, executive contributions, and earnings on …
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Development of a Human Immune System from Hematopoietic Stem Cells in a Human/Mouse Xenogeneic Model
… of severe combined immunodeficient (SCID) mice with human hematopoietic stem cells results in long-term engraftment and systemic reconstitution with human progenitor, B and myeloid cells but curiously, human T cells are rarely present in any tissue. While the implantation of SCID mice …
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Prevalence of Undiagnosed Dissociative Disorders in an Inpatient Setting
… coefficients were as follows: DDIS-DES-T = 0.81; SCID-D-DES-T = 0.76; Clinician-DES-T = 0.74, DDIS-SCID-D = 0.74; DDIS-Clinician = 0.71, and SCID-D-Clinician = 0.56. A meeting was conducted at the end of all subject interviews to discuss discrepant findings between measures. Four additional …
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In vivo Detektion und Quantifikation retroviral markierter humaner hämatopoetischer Stammzellklone in der Gentherapie
… von schweren kombinierten Immundefizienzen (SCID) eingestezt. Während der SCID-X1 sowie neuerdings auch der ADA-SCID gentherapeutisch geheilt werden können, ist unklar, warum die ersten klinischen Versuche erfolglos blieben. Das in dieser Arbeit untersuchte Material entstammt einer ADA-SCID …
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Identifizierung und Charakterisierung neuer Impfstoffkandidaten zum Schutz gegen die Lyme-Borreliose
… vor einer Nadelinfektion mit 103 Erregern in SCID-Mäusen vermittelten. Die meisten bislang beschriebenen Untersuchungen wurden an SCID-Mäusen nach Nadelinokulation durchgeführt. Die so gewonnenen Ergebnisse waren selten auf eine Zecken-vermittelte Infektion übertragbar. Auch die protektive …
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… into streptozotocin (STZ)-treated NOD/SCID mice. However, UCB-derived ALDHhi cells are rare and expansion without the loss of regenerative function is required. We hypothesized that BMS 493, an inverse retinoic acid receptor agonist, will prevent HSPC differentiation of HSPC during …
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Measurement Invariance Between Genders on Two Measures of Borderline Personality Disorder
… CFAs to evaluate MI between genders. The SCID-II BPD Scale (First, Gibbon, Spitzer, Williams, & Benjamin, 1997) was found to be measurement invariant between genders, while the PDI-IV BPD Scale (Widiger, Mangine, Corbitt, Ellis, & Thomas, 1995) did not meet criteria for strict measurement …
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Can the Triarchic Model Differentiate between Psychopathy and Antisocial Personality Disorder?
… beyond APD symptom counts (indexed by the SCID-II APD module) in predicting the PCL-R total score. Hierarchical linear regression analyses were conducted in which the SCID-II APD symptom count was entered in the first step of the model, and the three Triarchic domains were entered in the …
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Affect and Its Disorders in a Northern Plains Indian Community: Issues in Cross -Cultural Discourse and Diagnosis
… the Structured Clinical Interview for the DSM (SCID). Interviews with 75 tribal members from a single reservation revealed that respondents diagnosed with Posttraumatic Stress Disorder (PTSD) when interviewed by a community member using the CIDI were much more likely to be diagnosed instead with …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… anti-human CD19 MAb, HD37, has efficacy in SCID mice with human B cell tumors. Furthermore, homodimers consisting of two conjugated IgG molecules of HD37 are more effective than monomers at inducing tumor cell death. Yet, their large size prevents effective tumor penetration, and normal Fc …
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Schneiderian first-rank symptoms in schizophrenia and methamphetamine psychosis: a comparative study
… using structured clinical interviews for DSM-IV (SCID-I). Method: Data from SCID-I interviews collected on two samples of patients, diagnosed with schizophrenia and with methamphetamine psychosis, as part of two separate research projects, was retrieved from the respective databases and compared. …
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