Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 52 for “"SCFAs"”.
-
Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
… the direct effects of short-chain fatty acids (SCFAs), produced through bacterial fermentation of dietary fibers, on glucose and lipid metabolism in adipocytes. We show that the SCFAs propionic acid and butyric acid inhibit cAMP-stimulated lipolysis, a mechanism that is not dependent on the …
-
REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS
… microbiota produce short chain fatty acids (SCFAs) via dietary fiber fermentation. SCFAs have profound effects on the immune system. We investigated the roles of SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell differentiation and T …
-
Development of a headspace solid-phase microextraction (HS-SPME) procedure for the determination of short-chain fatty acids (SCFAs) in activated sludge by GC-FID
… treatment system. Short-chain fatty acids (SCFAs), an energy source of the bioorganisms, are produced during activated sludge digestion, and play a significant role in phosphorus and nitrogen removal as well as the removal of organic materials during the process of wastewater treatment. …
-
The Role of Short-Chain Fatty Acids on Intestinal Epithelial Cell Migration
… fiber is fermented into short-chain fatty acids (SCFAs) by the gut microbiota and is vital to proper gut function. Previous studies have found that diets lacking fiber, SCFAs, or receptors for SCFAs predispose both animals and humans to IBD and colorectal cancer. However, in order to utilize SCFAs …
-
On-trap derivatization of short-chain fatty acids
… by the production of short-chain fatty acids (SCFAs). There is a need for rapid, selective analytical methodology capable of trace analysis of SCFAs in complex biological matrices. Previous studies by others using multibed-sorbent traps, solid phase microextraction (SPME), and on-fiber …
-
Short Chain Fatty Acids Signaling through the G Protein-Coupled Receptor GPR41 in the Intestine.
… to produce short chain fatty acids (SCFAs). SCFAs constitute around 70% of the energy source in ruminants and 10-15% in non-ruminants. Recently, SCFAs have been shown to be ligands fortwo G protein-coupled receptors (GPCRs), Gpr41 and Gpr43. We show that Gpr41 is expressed in the …
-
SHORT-CHAIN FATTY ACIDS INDUCED AUTOPHAGY SERVES AS AN ADAPTIVE STRATEGY FOR RETARDING MITOCHONDRIA-MEDIATED APOPTOTIC CELL DEATH
… dietary fibers in human large intestine. SCFAs, mostly propionate and butyrate, inhibit proliferation and induce apoptosis in colon cancer cells, but clinical trials had mixed results regarding the anti-tumor activities of SCFAs. Herein we demonstrate that propionate and butyrate induced …
-
THE ROLE OF GUT METABOLITES ON REGULATION OF INTESTINAL IMMUNITY
… specifically short chain fatty acids (SCFAs) and retinoic acid (RA), in regulation of intestinal immune responses. Our research revealed novel pathways that SCFAs and RA use to contribute to anti-bacteria immunity through modulation of epithelial cells and innate lymphoid cells (ILCs), …
-
Microbiota regulate short chain fatty acids and influence histone acylations in intestinal epithelial cells.
… process, they produce short chain fatty acids (SCFAs) such as butyrate, an important energy source for intestinal epithelial cells. SCFAs are chemically related to histone acylations, a growing number of post-translational modifications that include histone acetylation, butyrylation and …
-
Genetic and environmental regulation of virulence genes in Salmonella enterica serovar Typhimurium.
… total concentrations and relative percentages. SCFAs representing the ileum and acetate alone are able to restore SPI-1 invasion gene expression to a barA mutant but not to a sirA mutant. Additionally, ileal SCFAs increase the expression of SPI-1 virulence genes required for invasion of …
-
Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
… A pathway (PKA) and short chain fatty acids (SCFAs). Differentiation-dependent SPRR2 expression was examined in cytoskeletal-, membrane-, and nuclear-enriched fractions by immunoblotting and confocal immunofluorescence. We studied the effect of SCFAs, known inducers of differentiation, on …
-
Applications of LC-MS metabolomic profiling in inflammatory bowel disease and the development of derivatisation methods to enhance selective detection of certain compound classes
… bases.;The analysis of short chain fatty acids (SCFAs) by LC-MS is a problem since they are too volatile to give good responses. SCFAs are potentially important makers for IBD. A quantitative LC-MS method for acetic, propionic, butyric and lactic acids was developed by carrying out derivatisation …
-
Impact of intestinal bacteria on the anatomy and physiology of the intestinal tract in the PRM/Alf mouse model
… to other mouse strains [2, 3]. Polyamines and SCFAs produced by gut bacteria are important growth factors, which possibly influence mucosal morphology, in particular villus length and crypt depth and play a role in gut lengthening in the PRM/Alf mouse. However, experimental evidence is lacking. …
-
Signals and Sensory Mechanisms that Impact Campylobacter jejuni-Host Interactions
… -- organic acids and short chain fatty acids (SCFAs) -- in C. jejuni commensal colonization. C. jejuni has both acetate and lactate utilization pathways, as well as for acetate production. I observed that acetogenesis mutants incapable of producing acetate were deficient for colonization of the …
-
In Vitro Analysis of Short Chain Fatty Acids and Human Fecal Microbiota Stimulated by Pectin Sources
… to determine the effects of pectin sources on SCFAs and BCFAs production and to investigate the changes in the community of the fecal microbiota. We selected 3 different pectins (HMP: high methoxy pectin from citrus pectin, SBP: sugar beet pectin, SOY: soybean pectin), based on the fact that …
-
Synthesis and application of tagging agents in mass spectrometry-based targeted metabolomics studies
… that the detection and quantification of SCFAs by LCMS was greatly enhanced by derivatisation and showed no difference in the levels of SCFAs between the treatment and control groups which implies that the diets had similar effects on the levels of SCFAs in urine and thus could be deemed …
-
Studies into the relationship between GPCR43 and BuA-induced effects on colorectal cancer.
… to produce the short chain fatty acids (SCFAs) acetate, propionate and butyrate (BuA). Each of the SCFAs are bioactive in the colon, with the most active being BuA. The beneficial effects of fibre have been linked to BuA’s ability to induce colon cancer cell differentiation, reduce …
-
Butyrate Sensing by Campylobacter jejuni Impacts Bacterial-Host Interactions
… metabolites, including short-chain fatty acids (SCFAs) and lactate. Due to the abundance and intestinal distribution of these metabolites, bacterial pathogens can use them as biogeographical cues to discriminate among different regions of the host intestines. Indeed, Campylobacter jejuni, a …
-
Community Composition and Function of the Hindgut Microbiome in Seaweed-Eating Marine Fish
… dietary macroalgae to short-chain fatty acids (SCFAs) that benefit the host. Microbial communities assist the fish host overcome nutritional limitations (e.g., protein, energy and vitamins). It is unclear which taxonomic groups contribute to the break down of dietary macroalgae along the fish …
-
Το μικροβίωμα του παχέος εντέρου στην καρκινογέννεση. Κλινική αξία στην πρόγνωση και θεραπεία της νόσου
… μεταβολιτών όπως τα λιπαρά οξέα βραχείας αλύσου (SCFAs), της ενίσχυσης του εντερικού φραγμού και της ρύθμισης του ανοσοποιητικού συστήματος. Ωστόσο, η δυσβίωση μπορεί να οδηγήσει σε διαταραχή αυτών των λειτουργιών, αυξάνοντας τη φλεγμονή, το οξειδωτικό στρες και τη βλάβη του DNA. Συγκεκριμένα …
Page 1 of 3