Global ETD Search
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Showing 1 to 10 of 10 for “"SCF complex"”.
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Discovery and Effects of Pharmacological Inhibition of The E3 Ligase Skp2 By Small Molecule Protein-Protein Interaction Disruptors
… protein 2), one component of the SCF E3 ubiquitin ligase complex, directly interacts with Skp1 and indirectly associates with Cullin1 and Rbx1 to bridge the E2 conjugating enzyme with its protein substrate to execute its E3 ligase activity. Skp2 is an Fbox protein (due to it …
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The Role of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis
… and this phosphorylation is essential for Skp2 SCF complex integrity and E3 ligase activity to ubiquitinate Akt, which is critical for Akt activation. Also, Skp2 S256 phosphorylation can be induced by many stress and EGF. The phosphorylation status is necessary for breast cancer tumor …
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The Gsk-3Β-Fbxl21 Axis Regulates Tcap Via Ubiquitin-Mediated Proteasomal Pathway In The Cytoplasm
… affects Skp, Cullin1(Cul1), F-box containing (SCF) complex/E3 ligase-Substrate complex formation. Interestingly, GSK-3β knockdown significantly inhibited FBXL21-CUL11 and FBXL21-TCAP complex formation. These results revealed a new circadian regulatory pathway that FBXL21 regulates TCAP via …
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Characterization of the IBR5-PAD1 Interaction in Arabidopsis Auxin Response
… by a multi-subunit E3 ubiquitin ligase complex, essentially tagging the target proteins for degradation by the 26S proteasome. One specific type of E3 ligase, the SKP1-CULLIN1-F-BOX protein (SCF) complex, is utilized by several plant hormones to ubiquitinate target proteins. This process …
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SCF SKP2B - AND KPC1-DEPENDENT DEGRADATION OF CYCLIN-DEPENDENT KINASE INHIBITOR KRP1 AND CELL CYCLE REGULATION IN ARABIDOPSIS THALIANA
… the activities of cyclin-dependent kinase/cyclin complexes. However, little is known about the role of this group of proteins in plant cell cycle regulation. To gain insight into the mechanisms by which the plant cell cycle is regulated, I studied the cyclin-dependent kinase inhibitor KRP1 in …
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DRE-1/FBXO11, a Conserved F Box Protein, Regulates Apoptosis in C. elegans and is Mutated in Human Lymphoma
… and genetic experiments that DRE-1 acts in an SCF complex with CUL-1 and SKR-1 to regulate tail-spike cell death, and present evidence that DRE-1 and CED-9 bind to each other in vitro. These results suggest a model in which the dre-1 SCF complex ubiquitinates CED-9 to eliminate its …
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Signalling pathway of FBXO7 and its role in hereditary Parkinsonism
… variable subunit of Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complexes and as such dictate substrate specificity. The canonical outcome of ubiquitylation is proteasomal degradation and my working hypothesis is that FBXO7 may be involved in protein quality control in the brain. A …
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Precise Temporal Regulation of Ribonucleoprotein Complexes during the Drosophila Maternal-to-Zygotic Transition
… the Smaug (SMG) RBP forms ribonucleoprotein complexes with corepressors, Trailer hitch (TRAL), Maternal expression at 31B (ME31B) and Cup, as well as AGO1 and the CCR4-NOT deadenylase to regulate the translation and stability of hundreds of maternal mRNAs, and this regulation is required for …
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ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… βTrCP, an F-box protein that acts in a larger SCF complex, is one of several E3 ligases that have been proposed to polyubiquitinate BIM. This study demonstrated that of the major isoforms of BIM only BIMEL interacts with βTrCP. ERK1/2-driven phosphorylation of BIMEL is essential for this …
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Mechanisms of Oct4 in the entry to, maintenance of, and exit from pluripotency
… upon being returned to the naïve epiblast. A complex transcription factor network promotes this state. Overexpression of one of many of these factors leads to stabilisation of the naïve state, with enhanced self-renewal and reduced spontaneous differentiation. However, the transcription factor …