Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"SCC1"”.
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Seismic Performance of Self-Consolidating Concrete Bridge Columns
… equivalent to 0.075f’cAg for Specimens CC1 and SCC1 and 0.15f’cAg for Specimens CC2 and SCC2. Lateral load reversals were applied to the specimens at successively increasing displacements until failure. The loading of Specimen SCC2 deviated from the planned loading protocol due to unintended …
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Regulation of Sister-Chromatid Cohesion
… determined the crystal structure of human SA2-Scc1 cohesin subcomplex, which is the interaction hub for cohesin regulators. Further biochemical and functional analyses reveal the direct competition between Wapl and the cohesion protector Sgo1 for binding to a conserved site on SA2-Scc1. Our …
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Die Funktion von Three rows bei der Schwesterchromatiden-Trennung in Drosophila melanogaster
… erfordert die proteolytische Spaltung des Scc1-Proteins. Scc1 ist Bestandteil des Kohäsin-Komplexes, der die Schwesterchromatiden nach ihrer Entstehung in der S-Phase bis zum Beginn der Anaphase gepaart hält. Die Protease, die durch Scc1-Spaltung die Schwesterchromatiden-Trennung einleitet, …
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The dual use of cohesin and its protector Sgo1 contributes to the choreography of the chromosome and the centrosome cycle
… protein complex cohesin forms a tripartite Scc1-Smc1-Smc3-ring around sister chromatids. In early mitosis cohesin is removed from chromosome arms by the phosphorylation-dependent prophase pathway. During this time, centromeric cohesin is protected by shugoshin 1 and protein phosphatase 2A …
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Analyse des meiotischen Cohesinkomplexes in Drosophila melanogaster-Weibchen
… SMC1, SMC3 und den zwei nicht-SMC Untereinheiten Scc1/Rad21/Mcd1 und Scc3/SA. In Metazoen wird der Großteil der Cohesinmoleküle während der Prophase vom Chromatin entfernt, während ein kleiner Teil am zentromerischen Chromatin verbleibt und erst beim Metaphase-Anaphase-Übergang durch eine …
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Human cohesin dynamics and their regulation in M and S phase
… ring structure composed of the three subunits Scc1, Smc1 and Smc3. For this thesis, I have studied cohesin's dynamic association with chromatin in M and S phase as well as its role at the mitotic centrosome, the main microtubule-organizing center of most eukaryotic cells. In order to separate …
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Studies of Aurora and Polo Kinases During Cell Division in C. elegans
… cohesion until the proteolysis of the cohesion Scc1 by separase triggers the separation of sister chromatids at anaphase. Chromosome dynamics during meiosis are more complex, as homologous chromosomes separate in anaphase I, whereas sister chromatids remain attached until anaphase II. In …
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Structural insights into the folding of cohesin and the membrane binding of bactofilin
… The cohesin complex is made up of Smc1, Smc3, Scc1 and additional subunits such as Scc3, Scc2, and Pds5. The Scc2 cohesin loader is involved in the “clamping” of DNA by the complex and promotes the hydrolysis of ATP through the engagement of the Smc1/3 heterodimer. Meanwhile, Scc2’s replacement …
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Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing
… Protein Astrin, sowie Proteine der Kinetochore (scc1, smc1, smc3, securin und separase) und Kinesin verwandte Motorproteine (MCAK, TPX2, HSET, KIA0622).Die Zinkfinger Metallprotease prozessiert das Zellkernprotein prelamin A durch endoproteolytische Entfernung der carboxyterminalen 16 Aminosäuren …
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The interplay of global chromosomal organisation, promoter-enhancer interactions and transcription
All somatic cells within an organism contain the same genetic material, yet they display pronounced differences in function and morphology. Precise control of gene expression is of fundamental importance to allow cells to properly develop, maintain homeostasis, and respond to external stimuli. The …