Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"SCAN1"”.
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Nonhomologous end-joining: TDP1-mediated processing, ATM-mediated signaling
… spinocerebellar ataxia with axonal neuropathy (SCAN1), a congenital neurodegenerative disease. SCAN1 is caused by a homozygous H493R mutation in the active site of tyrosyl-DNA phosphodiesterase (TDP1). To address how the H493R mutation elicits the specific pathologies of SCAN1 and to further …
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Action of Tyrosyl DNA Phosphodiesterase on 3'-Phosphoglycolate Terminated DNA Strand Breaks
… from spinocerebellar axonal neuropathy (SCAN1) were found to be deficient in PG-processing. Addition of JRLl whole-cell extract (SCAN1 extract containing mutant Tdpl) to purified FLAG-tagged hTdpl showed to decrease the phosphotyrosyl processing and increase the PG-processing of …
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Structural and Inhibitor Binding Studies of Tyrosyl-DNA Phosphodiesterase 1
… spinocerebellar ataxia with axonal neuropathy (SCAN1). There are current efforts to develop activators as well as inhibitors of H493R TDP1 to treat the SCAN1 disease. Chapter 2 described the work in the production and purification of truncated and mutant human TDP1. Expression trials were …