Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"SCA3"”.
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Magnetresonanztomographie-basierte Volumetrie bei hereditären spinozerebellären Ataxien
… quantifizieren, wurde bei 82 Patienten mit SCA1, SCA3 oder SCA6 sowie bei 31 Kontrollpersonen nach vorangehender Bildgebung mittels Magnetresonanztomographie (MRT) eine anschließende quantitative 3D-Volumetrie durchgeführt. Diese Untersuchung ergab für SCA1 und SCA3 schwere Atrophien des Pons, der …
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Using Chemically Modified Oligonucleotides to Modulate Gene Expression, Treat Genetic Diseases, and Probe Novel Mechanisms of RNA Interference
… mutated gene in spinocerebellar ataxia type 3 (SCA3). Taken together, we have identified and characterized a novel class of mechanistically interesting and therapeutically promising nucleic-acid-based compounds that could open new doors to finding a cure for genetic diseases such as HD.
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Suppression of Machado-Joseph disease pathogenesis by serotonergic signalling: the contribution of serotonin receptors
A doença de Machado-Joseph (DMJ) é uma doença debilitante caracterizada pela perda progressiva do equilíbrio e da coordenação motora. A nível molecular, a DMJ está associada à expansão da repetição de Citosina-Adenina-Guanina (CAG) no gene da ataxina-3. Isto traduz-se num segmento expandido de …