Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"SBMA"”.
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AR-A IPSCS: GENERATION OF AN ADVANCED CELLULAR MODEL TO INVESTIGATE A NOVEL THERAPEUTIC APPROACH FOR SBMA
Spinal and Bulbar Muscular Atrophy (SBMA) is a rare, highly disabling, neurodegenerative disease that unfortunately still lacks an effective treatment to date. Patients affected by SBMA present muscular impairment, characterized by cramps and muscle twitching in the early stages and by difficulty …
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Physiological and pathological role of serine 96 phosphorylation in the regulation of androgen receptor
Spinal and bulbar muscular atrophy (SBMA) is an X-linked neuromuscular disorder characterized by the progressive dysfunction and loss of lower motor neurons. SBMA is caused by the expansion of a CAG tandem repeat encoding a polyglutamine (polyQ) tract in the androgen receptor (AR) gene. SBMA …
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COMPOSTI AD AZIONE ANTI-AGGREGANTE ESERCITANO UN EFFETTO BENEFICO SU MODELLI CELLULARI DI ATROFIA MUSCOLARE SPINALE BULBARE
Spinobulbar Muscular Atrophy (SBMA) is a rare inherited X-linked neurodegenerative disease caused by an abnormal expansion of the CAG repeat, encoding for the poly-glutamine tract (polyGln), in the N-terminal region of the Androgen Receptor (AR) gene. This mutation leads the protein to form …
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Native Functions of the Androgen Receptor are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy
Spinobulbar muscular atrophy (SBMA) is a progressive, late-onset disease characterized by degeneration of motor neurons in the brainstem and spinal cord. The disease is caused by expansion of a polyglutamine tract in the androgen receptor (AR) and is dependent on exposure to AR ligand. The expanded …
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Modelling neurodegenerative diseases in human iPSC-derived neurons
… disease spinal and bulbar muscular atrophy (SBMA), detailed in Chapter 4. Using iPSCs derived from a healthy donor and an SBMA patient, the CAG repeat of the endogenous androgen receptor (AR) gene was CRISPR-edited to encode a series of lengths or an early stop codon. However, AR expression …
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Sviluppo di tecniche di analisi ifenate per la quantificazione di biomarcatori di esposizione a tossici ambientali: gli acidi mercapturici
… detection of the BTX exposure biomarker SPMA, SBMA and o-MBMA in human urine. Urinary S-phenylmercapturic acid (SPMA) is a biomarker proposed by the American Conference of Governmental Industrial Hygienists (ACGIH) for assessing occupational exposure to benzene (Biological Exposure Index of 25 …
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CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT
… of several neuromuscular diseases, including SBMA, Huntington’s disease, and ALS. The roles of BDNF and TrkB are not well-characterized in muscle or motor neurons. This study addressed the function of TrkB in neuromuscular junctions (NMJs) and its roles in motor neuron axonal transport. The …
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QUANTIFYING OLIGOMERIC STATES OF PROTEINS IN-CELL VIA SINGLE-MOLECULE SUPER-RESOLUTION MICROSCOPY
… applied it to two membrane proteins, UhpT and SbmA, in E. coli cells. While PDFMD is suitable for membrane proteins, direct application of PDFMD to cytosolic proteins is not feasible due to their heterogeneous intracellular distributions. To quantify oligomeric stoichiometry of cytosolic …
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Synthesis and Characterization of Zwitterion-Containing Acrylic (Block) Copolymers for Emerging Electroactive and Biomedical Applications
… oxy)ethyl](dimethyl)-ammonio]-1-propanesulfonate (SBMA) and 2-[butyl(dimethyl)amino]ethyl methacrylate methanesulfonate (BDMAEMA MS), respectively, yielded zwitterionomers and cationomers of comparable chemical structures. Differential scanning calorimetry (DSC), small-angle X-ray scattering …
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Preparation and Biocompatibility of Electrospun Zwitterionic Poly(Sulfobetaine Methacrylate) for Wound Dressing Applications
Poly(sulfobetaine methacrylate) (PSBMA) can be potentially utilized in filtration and wound dressing applications for which nanofibers structures are highly desirable. In this work, a series of PSBMAs with different molecular weights were synthesized, characterized, and electrospun into nanofibers. …