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Showing 1 to 16 of 16 for “"SB203580"”.
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Regulation of the beta7 integrin gene in T cells: role of the MAPK signalling pathways
… treatment of TK-1 cells with the p38 inhibitor SB203580 and the JNK inhibitor SP600125 inhibited the synthesis of β7 transcripts, whereas only SB203580 inhibited the synthesis of α4 transcripts. Conversely, sodium arsenite which induces JNK and p38 upregulated nascent synthesis of α4 and β7 RNA …
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Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders
… of IL-6 we used the inhibitors SP600125 and SB203580. SB203580 is a p38 MAPK inhibitor that targets the p38alpha and p38beta2 kinases, while the p38beta kinase exhibits only partially sensitivity. The inhibitor SP600125 targets the JNK kinase. (Abstract shortened by UMI.).
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Regulation of mRNA expression through 3’ UTR sequences of IL6 gene in amino acid-deprived HeLa cells
… Finally, treatments of p38 MAP kinase inhibitor, SB203580 markedly blocked mRNA stabilization through 3’UTR as well as IL6 induction after amino acid-starvation, suggesting that p38-MK2/3-TTP pathway is evidently activated and implicated in stabilization of IL6 mRNA during starvation of cancer …
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Estrogen Receptor -Dependent and Estrogen Receptor-Independent Pathways for Tamoxifen and 4-Hydroxytamoxifen-Induced Programmed Cell Death
… cell death. Since the p38-specific inhibitor SB203580 blocks OHT-ER induced cell death, stress kinase pathways are likely involved. ER-independent cell death triggers classic caspase-dependent apoptosis. However, while OHT-ER triggers some hallmarks of apoptosis, including Bax translocation …
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Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
… to be dependent on p38 MAPK activity, as use of SB203580 can block the hypoxia-mediated proliferative response to acute hypoxia (Scott et al, 1998; Welsh et al, 2001). Aims and methods: We wished to establish whether the pro-proliferative response of PAFB to acute hypoxic exposure previously …
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Approaches to Reduce Selection of Genomic Variants in Human Pluripotent Stem Cell Culture
… MEK inhibitor (PD0325901) and p38 inhibitor (SB203580), we demonstrate that hPSCs are LIF responsive and can be stably maintained in naive pluripotent culture conditions. Based on their clonal viability, we propose that naive hPSCs are a more genetically stable population than primed hPSCs, …
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Effects of phosphatidylinositol on ApoA-I metabolism: Implications in HDL metabolism
… kinase inhibitors. While the p38MAPK inhibitor SB203580 has no effect on PI-induced apoA-I secretion, the MEK1/2 inhibitor U0126 blocks PI-induced apoA-I secretion. Inhibition of the JNK MAPK pathway by SP600125 also blocks PI mediated apoA-I secretion. Real-time PCR shows no changes in cellular …
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Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
… assessed by addition of a specific inhibitor, SB203580, to the cells under investigation. Results and Discussion: It was shown that PGE2 alone could not trigger proliferation of the Het1a cell line. Though, the effect of p38 might be positive. Acute H2O2 treatments turned out encouraging in the …
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Examining Altered NF-κB Signalling Following 1,4- Benzoquinone Exposure in HD3 Cells
… and pre-treatment with the p38-MAPK inhibitor, SB203580, attenuated BQ-mediated increased NF-κB activity, partially due to increased IκB-α protein expression. At this point, the chosen downstream targets were not significantly different compared to control. Future studies should continue to …
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Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
… were inhibited by MAP kinase inhibitors SB203580 and U0126, thus suggesting that the SCFA effect may be mediated by orphan G-protein receptors GPR41 and GPR43. S. typhimurium induced SPRR2 in undifferentiated cells. We conclude that SPRR2 protein expression is associated with …
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Regulation of acid-stimulated H+ secretion by Pyk2 and MAPK signaling pathways in the outer medullary collecting duct
… at Tyr402 as well as the p38-specific inhibitor, SB203580. The pH-sensitive fluorescent probe BCECF-AM was used to assay H+ transporter activity. The activity of H+ transporters was measured as the rate of intracellular pH recovery after an NH4Cl pre-pulse. We show that Pyk2 is endogenously …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… expression levels. Inhibition of p38 MAPK by SB203580 in high glucose attenuated the increased number of pyknotic-like nuclei in high glucose and enhanced the number of EdUpositive nuclei compared to high glucose alone. High glucose also reduced the expression of the mitochondrial fusion …
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The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… 1μM fluvastatin and the p38 MAP kinase inhibitor SB203580 selectively blocked the hypoxic PAF-PASMC interaction. Results with hypoxic PAF proliferation with the prostacyclin analogue treprostinil, the phosphodiesterase-5 inhibitor sildenafil and the endothelin-1 antagonist bosentan were negative. …
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Mechanisms of soy isoflavones in the regulation of vascular function
… of p38 mitogen-activated protein kinase (p38) by SB203580 completely abolished the cytoprotective effect of genistein, suggesting that genistein acted through the p38-dependent pathway. Accordingly, stimulation of HAECs with genistein resulted in rapid and dose-dependent activation of p38. Unlike …
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Role of the Leukotriene B4 Metabolic Pathway in Human Pancreatic Cancer
… activation of p38 MAPK. The p38 MAPK inhibitor SB203580 was able to block the LTB,-induced activation of p38 MAPK but not cell proliferation. The serine/threonine kinase Akt/PKB was also phosphorylated following LTB, treatment. The PI-3 kinase inhibitor wortmannin partially blocked LTB,-induced …