Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"SARS-CoV-2 pandemic"”.
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AN IMPROVED GENOMIC SURVEILLANCE APPROACH TO DISSECT THE SARS-COV-2 PANDEMIC
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only approach to rapidly monitor and tackle emerging variants of concern (VOC) of the COVID-19 pandemic. Such scrutiny is crucial to limit the spread of VOC that might escape the immune protection conferred by vaccination …
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The impact of the SARS-COV-2 pandemic on maternal mortality in a South African Metropole (2020-21)
Background: During the COVID-19 pandemic there was a notable increase in maternal deaths across South Africa. Pre-pandemic, the Western Cape Province had made significant strides towards reducing maternal mortality. However, this progress was reversed in the pandemic period despite a relative …
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Escherichia coli infection: mechanisms and rapid detection of resistance to the association of ß-lactams with ß-lactamase inhibitors, and impact of the Sars-Cov-2 pandemic on the morbidity and mortality of intra-abdominal infection
… their isogenic resistance to P/T. Finally, the COVID-19 pandemic by the new SARS-CoV-2 arose new questions derived from the great challenge to the Health Systems and, specifically, in the case of the intra-abdominal infections, about of the impact of the pandemic on the management of them, and …
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Erfolgsfaktoren des Supply-Chain-Risikomanagements in der Krise – Eine empirische Analyse kleiner und mittlerer B2C-Unternehmen in Deutschland am Beispiel der Coronapandemie
Although a pandemic is a conceivable scenario in a globalised economy, the SARS-CoV-2 pandemic that broke out in November 2019 represented a first in recent history with its profound impact on companies and society as a whole. With the global spread of the pandemic, Germany also experienced a …
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The implementation of a rapid sample preparation method for the detection of SARS-CoV-2 in a diagnostic laboratory in South Africa
The SARS-CoV-2 pandemic has resulted in shortages of both critical reagents for nucleic acid purification and highly trained staff as supply chains are strained by high demand, public health measures and frequent quarantining and isolation of staff. This created the need for alternate workflows …
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MINING SARS-COV-2 PHYLOGENETIC TREES TO ESTIMATE CIRCULATING INFECTIONS AND PATTERNS OF MIGRATION
The SARS-CoV-2 pandemic led to the formation of very large databases of genomic viral data. These databases contain information on transmission dynamics, emergence and evolution of SARS-CoV-2. However, extracting this information from sequences is difficult, as most methods of analyzing viral …
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High-throughput sequencing to understand pathogen carriage and transmission
… *Staphylococcus aureus* and, in response to the SARS-CoV-2 pandemic, I examine the transmission of SARS-CoV-2, two critically important human pathogens. To address this, I have utilised genomic and individual-level epidemiological data, acquired through the CARRIAGE study and the COVID-19 …
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Biochemical mechanisms for selectivity governing RNA and DNA replication
… finishing studies on the T7 DNA polymerase, the SARS-CoV-2 pandemic devastated the world. I used techniques developed in my previous studies to characterize the RNA dependent RNA polymerase (RdRp) from SARS-CoV-2, a prime target for antiviral drugs to stop replication of the virus. I developed …
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Supporting Special Education Student's Academic Engagement Behavior With Mindfulness-based Programming
… all in-person education related to the SARS-COV-2 pandemic in the middle of this study, only one of the special education classrooms containing 12 students (3 who participated in the current research) were administered the SOF intervention. Direct observation data of student on- and …
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MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN:LONGITUDINAL BODY COMPOSITION ASSESSMENT, INFLAMMATORY MARKERS, AND FATTY ACIDS PROFILE
The Sars-Cov 2 pandemic mainly affected the adult population. However, a small portion of children were affected by Multisystem Inflammatory Syndrome in Children (MIS-C). The severity of the syndrome required patients to be hospitalised and, in some cases, admitted to pediatric intensive care …
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Impact of SARS-COV2 pandemic on emergency surgical services at Groote Schuur Hospital
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic on emergency surgery services revealed an 87.8% decrease in procedures. The aim of the study was to determine the impact of the coronavirus 19 (COVID-19) pandemic on the number of emergency surgical operations performed at …
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High flow nasal oxygen versus mechanical ventilation as initial respirator support in severe COVID-19 ARDS at Groote Schuur Hospital : a propensity score analysis
… Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic placed an unprecendented burden on global health care resources, and on intensive care unit (ICU) resources in particular. Due to ICU resource limitations, high flow nasal oxygen (HFNO), a novel ventilation strategy, was …
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Within Host and Multiscale Models of Usutu and SARS-CoV-2 Viral Infections with Animal Hosts
… years have shown us the profound impact that SARS-CoV-2 pandemic has had on human kind and made us aware of the dangers that emerging pathogens can present. The goal of this dissertation is to use mathematical models in connection with data to uncover mechanistic interactions governing viral …
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Prediction and surveillance of antigenic variation in influenza and SARS-CoV-2 viruses
… for influenza vaccinology. During my PhD, SARS-CoV-2 began exhibiting antigenic variation analogous to that seen in influenza, prompting the development of similar surveillance systems and prediction methods as historically applied to influenza. Traditionally, these prediction methods have …
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CHARACTERIZATION OF THE INTERACTION BETWEEN HEPARAN SULFATE AND THE SPIKE (S) PROTEIN OF THE LATEST SARS-COV-2 VARIANTS
… and sulfate-rich sequences alternate. HS is covalently attached to the membrane protein (via the O- or the N-glycosylation of a Ser or Asn residue, respectively), forming heparan sulfate proteoglycans (HSPGs). Due to the pronounced density of negative charge of HS, HSPGs play a key role in …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
… possibly used as drug target, a recently discovered one is STING: a downstream actor in the detection of non-self cytosolic nucleic acids related to viral infections and tumor conditions. The Stimulator of Interferon Genes (STING) plays a pivotal role in counteracting viral infections, …
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Interplay between Extra-Germinal Center expansion of memory B cells and affinity maturation during the humoral recall response
… by effective vaccines that curtailed the SARS-CoV-2 pandemic. Vaccines prime the immune system to mount tailored responses against antigens, like pathogen-derived proteins. However, some viruses can evolve to evade these immune responses. Targeting the regions of viral proteins that are …
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Advancing RNA Virus Discovery and Biology with Whole Genome Sequencing
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within reservoir and spillover hosts.</p> <p>In my research studies, I used the amplicon-based WGS approach to define the genetic plasticity of viral RNA within pathogenic and nonpathogenic hantavirus species. The standing genetic …
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Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
The recent SARS-CoV-2 pandemic highlighted the lack in pandemics preparedness for hCoVs potential future spillovers and for other (+)ssRNA viruses that still lack approved pharmacological treatments such as Flaviviruses. Small molecule development stands out as the most promising approach, as it …
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Natural Genetic Variants in Humans and Salmonellae Underlie Variable Infection Outcomes
<p>As the current SARS-CoV-2 pandemic highlights, infectious diseases outcomes range from asymptomatic cases to prolonged morbidity and death. We can predict these outcomes using risk factors like age and BMI; however, we currently lack the capacity to generate more fine-grained, or even …
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