Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"SARS-CoV-2 Vaccines"”.
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Site-specific chemical and topological modifications to augment mRNA therapeutic potential
… Despite clinical demonstrations of mRNA for SARS-CoV-2 vaccines, mRNAs remain limited in application by their susceptibility to nucleases and overall short expression lifetime in vivo. We investigated the site-specific installation of chemical and topological modifications into therapeutic …
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Identifying and Characterizing Transition Cells in Developmental Processes from scRNA-Seq Data
… mouse model and humoral responses against SARS-CoV-2 vaccines. By identifying transition cells in pancreatic preinvasive lesions, we observe tumor heterogeneity and can predict distinct cell fate even at early stages of tumorigenesis. Additionally, characterizing transition cells after …
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Computational Study of Vaccination Strategies to Change B Cell Immunodominance
… presents a challenge in the development of vaccines against mutable viruses like HIV, influenza, and SARS-CoV-2 which rapidly modify the immunodominant epitopes and render existing antibodies ineffective. Moreover, as the immune system preferentially targets immunodominant epitopes, …
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COVID-19 Vaccine Hesitancy in a US Public University Cohort
COVID-19 is a threat to university reopening. Universities are sites of dense human contact, congregate living, and heterogenous mixing patterns that may increase risk of viral transmission within and between social groups. Understanding attitudes toward vaccine uptake is critical to strategic …
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Developing SINrep5 as a Viral Vector Platform to Test SARS-CoV-2 Vaccine Candidates
The COVID-19 pandemic, caused by SARS-CoV-2, serves as a stark reminder of the importance of vaccines and immunization in the arms race against novel viral agents. SARS-CoV-2 vaccines target the mutation-prone Spike Protein, leading to the rise of viral variants, and warranting additional research …
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Responding to an Evolving Pandemic: Characterisation of Emerging Evolving Viruses and Population Immunity by the Example of SARS-CoV-2
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human population in 2019 presented extraordinary challenges to the scientific community, and at the same time unique opportunities. Following the evolution of a novel human virus, together with the development of population …
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Development and Characterization of a Modified Vaccinia Ankara Vaccine Candidate Expressing the SARS-CoV-2 Spike Glycoprotein
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2, SARS-CoV-2. Given the ongoing COVID-19 pandemic and the continued evolution of the virus to escape host immunity, new vaccines and refinement of first-generation vaccines to improve protection against …
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Saftey of Covid-19 Vaccines in Real World Studies
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been present since its outbreak in 2019. Despite global efforts to fully halt its spread, new strains are emerging daily. Various efforts have been undertaken to slow down the infection's spread by implementing different …
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Prediction and surveillance of antigenic variation in influenza and SARS-CoV-2 viruses
… for influenza vaccinology. During my PhD, SARS-CoV-2 began exhibiting antigenic variation analogous to that seen in influenza, prompting the development of similar surveillance systems and prediction methods as historically applied to influenza. Traditionally, these prediction methods have …