Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 572 for “"SARS"”.
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SARS-CoV-2 detection in wastewater
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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SARS-CoV-2 Variants and Vaccines
SARS-CoV-2 is a novel betacoronovirus that first appeared in late 2019 in Wuhan, China. It presented with pneumonia-like symptoms and infections ranged from mild to severe, requiring hospitalisation and medical intervention to prevent death. Due to a lack of previous immunity, SARS-CoV-2 spread …
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High Throughput Sequencing of SARS-CoV-2
… in Wuhan China, later to be classified as SARS-CoV-2 and commonly referred to as COVID-19. This outbreak eventually spread to a global pandemic that has affected over 132 million people worldwide. Our goal was to develop optimized methods to sequence the whole SARS-CoV-2 genome so we could …
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Evaluation of two SARS-CoV-2 immunoassays
… (qualitative) and anti-spike (quantitative) SARS-CoV-2 immunoassays to determine whether the performance of the assays is acceptable for diagnostic use in the Groote Schuur Hospital virology/chemistry laboratory, as well as other National Health Laboratory Service (NHLS) laboratories in South …
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NEW-ONSET HYPERGLYCEMIA AFTER SARS-COV-2 INFECTION
… Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection may hasten the onset of metabolic changes. Here, they are described different abnormalities, such as glycometabolic regulation, insulin resistance, and loss of beta cell function in COVID-19 patients. Most of those individuals …
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Investigating SARS-CoV-2 immune responses in children
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infec<on causes a highly transmissible respiratory disease, coronavirus disease 2019 (COVID-19), with variable disease outcomes. Children infected with SARS-CoV-2 are more likely to exhibit asymptoma<c or mild illness compared to severe …
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SARS-COV-2 DISSEMINATION USING UNITED STATES COUNTY ADJACENCIES
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is increasing amongst the world’s population at an alarming rate. Reducing the spread of SARS-CoV-2 is paramount for public health officials as they seek to effectively manage resources and potential population control …
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Human Antibody Response to Flaviviruses and SARS-Coronavirus-2
… severe acute respiratory syndrome coronavirus (SARS-CoV-2). The first part of this thesis focuses on encephalitis-causing tick-borne flaviviruses, specifically TBEV and POWV. Both TBEV and POWV are emerging human pathogens that cause potentially fatal disease; there are no disease-specific …
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Genetics and functions of the SARS coronavirus spike protein
The SARS-Coronavirus (SARS-CoV) is the etiological agent of the severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. Investigations, described herein, have focused on the genetic …
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Developing novel prophylactic approaches against SARS-CoV-2 infection
Prevention of SARS-CoV-2 entry into cells through the modulation of viral host receptors, such as ACE2, could represent a new chemoprophylactic and therapeutic approach for COVID- 19 complementing vaccination. However, the mechanisms controlling ACE2 expression remain elusive, partly due to low …
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Profiling Host Respiratory Responses to SARS-CoV-2 Infection
… Over the past three years, we have studied SARS-CoV-2 infection through the lens of single-cell genomics, querying pre-existing single-cell datasets, developing in vitro models of disease, validating animal models of infection, and profiling human samples with our clinical collaborators, all …
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CELLULAR AND MOLECULAR PATHWAYS CONTROLLING SARS-COV2 ASSEMBLY AND EGRESS
SARS-CoV-2 is an enveloped, single-stranded, positive-sense RNA virus belonging to the family of Coronaviridae. Coronaviruses assemble on intracellular membranes, differently from many other RNA viruses that assemble and egress directly at the plasma membrane. This feature adds an additional layer …
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Molecular Mechanisms Behind Sars-Cov-2 Induced Host Genome Restructuring
… Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has caused unprecedented morbidity and mortality worldwide.<strong> </strong>There are two pathophysiological hallmarks associated with severe patient outcomes after SARS-CoV-2 acute infection, namely delayed/weakened interferon …
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A critical analysis of SARS' implementation of Advance Pricing Agreements
… (APAs) by the South African Revenue Service (SARS). Specifically, the transfer pricing legislation of selected foreign countries that implemented APAs as well as the Organisation for Economic Corporation and Development (OECD) transfer pricing guidelines were analysed to determine whether …
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Clinical validation of SARS-CoV-2 RT-LAMP in animals
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Surveillance of SARS-CoV-2: From Sewage to the Clinic
… shown that wastewater surveillance could detect SARS-CoV-2 before it became widespread in a population, and that viral levels in wastewater largely paralleled local increases in clinical cases of COVID-19. These studies highlight the potential of wastewater surveillance to provide early warning …
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Genetic diversity of sars-cov-2 in southern province of Zambia.
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has spread globally with catastrophic effects on the public health system. Four main Variants of Concern (VOCs), namely Alpha, Beta, Delta and Omicron, have been associated …
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Genetic diversity of sars-cov-2 in southern province of Zambia.
… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has spread globally with catastrophic effects on the public health system. Four main Variants of Concern (VOCs), namely Alpha, Beta, Delta and Omicron, have been associated …
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Spike Processing and Protease Usage Effects on SARS-CoV-2 Pathogenesis
The emergence of SARS-CoV-2 and its subsequent variants have ignited a multitude of studies on the spike protein and its domains. While most studies focus on the impact of receptor binding domain changes, mutations in the C-terminus of S1 (CTS1) have largely been overlooked. The SARS-CoV-2 CTS1 …
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