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Showing 1 to 4 of 4 for “"SARD"”.

  1. Investigation of the Serological Changes that Discriminate Asymptomatic Antinuclear Antibody Positive Individuals from Systemic Autoimmune Rheumatic Disease Patients

    … Systemic Autoimmune Rheumatic Diseases (SARDs) are chronic rheumatic disorders associated with high morbidity. Many patients with these diseases have irreversible tissue damage at disease presentation. Current therapies aim to control symptoms and prevent further damage by lessening the …

    toronto-retro Repository record for Investigation of the Serological Changes that Discriminate Asymptomatic Antinuclear Antibody Positive Individuals from Systemic Autoimmune Rheumatic Disease Patients (opens in a new tab)

  2. Androgen Receptor: A Complex Therapeutic Target in Breast Cancer

    … domain (NTD)-binding selective AR degrader (SARD) that irreversibly inhibits AR or by the JAK inhibitor ruxolitinib. Subsequent biochemical analysis suggests that STAT1 is an AR coactivator, and SARD or ruxolitinib blocks this coactivation.</p> <p>Collectively, we identified that AR has …

    tenn-hsc Repository record for Androgen Receptor: A Complex Therapeutic Target in Breast Cancer (opens in a new tab)