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Showing 1 to 16 of 16 for “"SAPK"”.
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Regulation of ERK1/2 and SAPK/JNK Phosphorylation by Histamine
… is implicated in allergic disease and asthma and SAPK/JNK and ERK1/2 are involved in certain aspects of allergic inflammation such as TH2 differentiation and proliferation and apoptosis. This study was designed to investigate the effects of histamine on ERK1/2 and SAPK/JNK phosphorylation in …
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Die Rolle einer konstitutiv-aktiven MAP-Kinase SAPK-Beta bei der zellulären Transformation, Proliferation und Apoptose von NIH-3T3-Fibroblasten
… (auch als Stress-aktivierte Proteinkinasen SAPKs bezeichnet), handelt es sich um Mitglieder der Mitogen-aktivierten Proteinkinase Familie (MAPK), die die Genexpression als eine Antwort auf eine Vielzahl von physiologischen und nicht-physiologischen Stimuli regulieren. Gendeletionsexperimente …
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Cell lineage choice during differentiation of trophoblast stem cells (tsc) is dependent on oxygen levels, and mediated by stress enzyme pathways and mitochondrial function
… markers; 4) increased activity of stress enzyme SAPK/JNK. By these parameters applying on different oxygen cultured TSC, we identified that 2% oxygen is the optimal oxygen environment for TSC mutipotency maintenance and proliferation. Additionally, TSC cultured in ambient environment in the …
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Integration of the phosphorylation-dependent signaling in the DNA damage response network : implications for cancer
… explore the p38/stress-activated protein kinase (SAPK) axis of DNA damage signaling, we determined the optimal phosphorylation motifs of mammalian p38/SAPK and MAPKAP Kinase-2. The optimal substrate phosphorylation motif for MAPKAP Kinase-2 closely matches the 14-3-3-binding site on CDC25B/C, and …
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Regulation von MAPK Signalwegen durch die Sein/Threonin Kinase MLK3
… zeigen wir, dass MLK3 Cdc42/Rac induzierte JNK/SAPK Aktivität vermittelt, welches zu einer anschließenden Phosphorylierung und verstärkter transkriptioneller Aktivität des zur AP-1 Familie gehörenden immediate early Gens c-Jun führt. Zusätzlich phosphoryliert MLK3 die dualspezifischen Kinasen …
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Untersuchung Influenza Virus-induzierter Signalprozesse und deren Bedeutung in der Wirtszell-Abwehr
… AP-1 abhängige Genexpression über den JNK/SAPK-Signalweg erfolgt (Ehrhardt, 1999; Ludwig et al., 2001). Unter den, an DNA Elemente bindenden AP-1 Faktoren waren solche, die aufgrund von Phosphorylierung durch die JNKs reguliert werden, wie beispielsweise ATF-2. Weiterhin korrelierte die …
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Utilising Yeast as a Model Organism to Deconstruct the Regulation of Tumour Associated Lipogenesis
… that stress-activated protein kinase pathways (SAPK) play a key role in regulating lipid accumulation upon nitrogen limitation, as cells enter the stationary phase of growth. Evidence from S. cerevisiae proposes that the lipogenic switch occurs in two phases, with the central MAPK (Hog1) …
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Effect of the ligands of thyroid hormone receptor on non-alcoholic fatty liver disease
… and activation of phospho-STAT3 and phospho-SAPK/JNK. Finally, additional experiments showed that GC-1, which has no significant side effects on heart rate, prevented and reverted CMD-induced fat accumulation. These results indicate that TR agonists have the potential to inhibit or reverse …
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Mechanical Strain-Mediated Syndecan Regulation and Its Effects on Adhesion of Vascular Smooth Muscle Cells
… kinase / stress-activated protein kinase (JNK/SAPK) signaling pathways were found to be required for the observed strain-induced shedding. These findings offer a better understanding of syndecan function in response to mechanical strain and suggest potential new mechanisms by which physical …
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Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
… effects of palmitate on the activation of MAPKs (SAPK/JNK and p38), iNOS expression and caspase-3 activity is mediated via activation of GPR40. A modulated expression of GPR40 in the islets i.e. overexpression (fa/fa rats) was accompanied by an exaggerated secretion of insulin, glucagon and marked …
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Propriedades anti-inflamatórias e antioxidantes dos extratos aquosos das folhas de Turnera subulata Sm. E Anacardium occidentale L.
… on the phosphorylation of ERK½, SAPK/ JNK and p38. In this way, our results indicate the possible antioxidant and anti-inflammatory effects of the aqueous extracts of T. subulata and A. occidentale and demonstrate the possible biological mechanisms responsible for these effects.
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Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function
… phosphorylation of the pro-apoptotic signals SAPK/JNK and p38. Second, we studied serotonin (5-HT) receptors in human islets and INS (832/13) cells. We detected 15 different 5-HT receptors and the 5-HT producing enzymes, TPH1 and TPH2 as well as DDC. Cellular localization for 5-HT1A, 5-HT1D …
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A Protective Role Of Autophagy In A Drosophila Model Of Friedreich's Ataxia (frda)
… activities by examine whether the AMPK or SAPK stress response pathway is involved in FRDA flies. Our hypothesis is the up-regulation of autophagy occurs in the early stage of FRDA and may induce apoptosis or mitophagy. We identified that autophagy level is up-regulated in FRDA flies at …
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Untersuchungen zur Funktion der Protein-Tyrosin-Phosphatase PTPRR
… MAPKn ERK1/2, nicht jedoch p38 Kinase oder JNK/SAPK dephosphoryliert. Zudem wurde über Transkriptionsaktivierungs-experimente der Nachweis erbracht, daß PTPRR die ERK1/2-vermittelte Aktivierung von Transkriptionsfaktoren negativ beeinflussen kann. Bei der näheren Untersuchung der Wechselwirkung …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… protein kinase c-Jun N-terminal kinase (SAPK/JNK). Each MAPK signaling pathway contains a three-tiered kinase cascade comprising a MAPKKK, that can activate MAPKK, which in turn activates and phosphorylates MAPKs [170]. Activation of MAPK pathways regulates the activity of a number of …