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Showing 1 to 20 of 36 for “"SAMP"”.
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Asymmetric synthesis of lignans and of α-heteroaryl)alkylamines employing the SAMP-/RAMP-hydrazone method
… 1,2-addition of heteroarenyllithium species to SAMP-/RAMP-hydrazones, has been developed. Moreover the novel methodology was successfully applied to the synthesis of biologically interesting compounds such as a-aminoacids and b-aminosulfones.
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Asymmetrische Synthese neuer planar- und zentral-chiraler Ferrocenylliganden
… ferrocenyl diketones via our SAMP/RAMP-hydrazone method. Keystep is the stepwise diastereoselective ortho-metalation of 1,1'-bisbenzoylferrocene-bis-SAMP-hydrazone followed by trapping of various types of electrophiles. Within our studies we demonstrate the broad applicability …
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Characterization and patterned polymer films from a novel self-assembly process
… to fabricate ultrathin multilayer films (SAMp). In this process, monolayers of polycations and polyanions are sequentially adsorbed onto a substrate surface by alternately dipping the substrate into aqueous solutions of poly(vinylamine) backbone azo (PDYE), poly(sodium 4-styrenesulfonate) …
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Asymmetrische Synthese von Tarchonanthuslacton und Pironetin-Bausteinen
… in the synthesis are an unsaturated SAMP-hydrazone and an alpha,beta-unsaturated lactone. The SAMP-hydrazone was easily prepared utilizing a stereoselective alpha-alkylation of diethyl SAMP-hydrazone using crotylbromide in good yield (86%) and diastereomeric excess (92%). The other …
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Zur asymmetrischen Synthese von Beta-Thio-Alpha-Aminosäuren
… amino acids described using chiral Amines or the SAMP-/RAMP-hydrazone methodology. Nearly all retrosynthetic approaches are starting with Bromacetaldehyde-Diethylacetale, which is nucleophil substituted with thiolates. After acidic hydrolyses of the acetals the correspending sulphur-substituted …
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Untersuchungen zur diastereo- und enantioselektiven Synthese von Matsuon und asymmetrische Synthese von anti-1,2-Sulfanylaminen
… the desired natural product described using the SAMP- /RAMP-hydrazone method. Several chiral building blocks were synthesized in high diastereomeric and enantiomeric excesses but the title compound could not be obtained. In the second part of the thesis a flexible diastereo- and enantioselective …
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Neue Ankergruppen für die enantioselektive kombinatorische Festphasensynthese
… desired substances. In order to synthesize a "SAMP-resin", a trityl-protected precursor was synthesized from trans-4-Hydroxy-L-proline and linked to Merrifieldïs-resin. Deprotection, nitrosation and reduction lead to the "SAMP-resin". Hydrazones based on this "SAMP-resin" were used in …
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State analysis modeling program
… systems, utilizing a digital computer, contain samplers as well as linear and nonlinear elements. State space techniques are the best means for analyzing systems of this type. SAMP (State Analysis Modeling Program, SAMPler), a digital computer program, uses these techniques in order to provide …
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Evaluation of a Novel Self-Assembled Nanocoating in Promoting Bone On-growth and Apposition on Metal
… monolayer of phosphonate molecules (SAMP) that chemically enhances metallic surfaces by covalently bonding to their naturally occurring oxidized surfaces has been developed.1 The SAMP coating is chemically stable, and its in-vitro results showed that it promotes cell proliferation, …
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Asymmetric synthesis of trisubstituted isoindolines and tetrahydropalmatine via tandem 1,2-addition-cyclisation
… process was developed. After condensation of SAMP with o-phthalic dicarboxaldehyde, the remaining aldehyde functionality was transformed into different alkenes by Horner-Wadsworth-Emmons reaction. Addition of a organolithium reagent/cerium chloride combination to a solution of the …
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Asymmetrische Synthese von 2-Methyl-substituierten 1,3-Diolen
… with (S)-1-amino-2-methoxymethylpyrrolidine (SAMP) to the respective SAMP-hydrazone proved to be an excellent platform for general asymmetric synthesis. Consequently in 1989 we published a stereoselective a-alkylation of the respective SAMP-hydrazone followed by oxidative auxiliary cleavage to …
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Asymmetrische Synthese von Gamma-Hydroxy-Alpha-Aminosäuren, 1,3-Aminoalkoholen und 2-Amino-3-Phosphonopropionsäure
… substituted substrates. Starting from aldehyde SAMP-hydrazones we obtained beta-hydroxy SAMP-hydrazones in a titanium-mediated aza-analogous aldol reaction. After protection, 1,2-addition and cleavage of the chiral auxiliary the products could be isolated over five steps in 30 to 54% overall …
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Zur asymmetrischen Synthese von C-Azanucleosiden und 2-Amino-1,3-diolen
… The different approaches envisaged, using the SAMP- /RAMP-Hydrazone methodology to synthesese the desired compound are herein described. Several chiral building blocks were synthesized in high diastereomeric and enantiomeric excess however the titled compound could not be obtained. In the …
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1,3-Aminoalkohole als Bausteine in der asymmetrischen Synthese von Azetidinen, Azetidincarbonsäuren und Piperidin-3-olen
… = 96-99%) in good overall yields starting from SAMP-hydrazones is described. Virtually stereoisomerically pure differently N,O-protected 1,3-amino alcohols were prepared as intermediates. By using the phenyl moiety as a synthetic equivalent of the carboxylic acid function, this protocol could …
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