Global ETD Search

AN INVESTIGATION OF THE REDOX REGULATION OF THE DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE SAMHD1 AND ITS ROLE IN NUCLEOTIDE HOMEOSTASIS

Mauney, Christopher HolbrookWake Forest University2017

… this study was to investigate the regulation of SAMHD1 and its relation to nucleotide metabolism and cell cycle progression. Phosphorylation of SAMHD1 is the most extensively documented means of regulation. While questions still remain regarding regulation of SAMHD1 by phosphorylation, this work …

wfu Repository record for AN INVESTIGATION OF THE REDOX REGULATION OF THE DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE SAMHD1 AND ITS ROLE IN NUCLEOTIDE HOMEOSTASIS (opens in a new tab)

DEVELOPMENT OF 4'-ETHYNYL-2'-DEOXYCYTIDINE (EdC), A REPLICATION-STRESS INDUCING NUCLEOSIDE ANALOG PRODRUG WITH PREFERENTIAL ACTIVITY IN LEUKEMIA AND LYMPHOMA SUBTYPES

Calbert, MarissaTemple University. Libraries2024

… EdC was resistant to cytidine deamination and SAMHD1 metabolism mechanisms and exhibited higher potency against ALL compared to FDA approved nelarabine. Finally, EdC was highly effective against DLBCL tumors and B-ALL in vivo. These data characterize EdC as a pre-clinical nucleoside prodrug …

temple Repository record for DEVELOPMENT OF 4'-ETHYNYL-2'-DEOXYCYTIDINE (EdC), A REPLICATION-STRESS INDUCING NUCLEOSIDE ANALOG PRODRUG WITH PREFERENTIAL ACTIVITY IN LEUKEMIA AND LYMPHOMA SUBTYPES (opens in a new tab)

Ribonuclease H2, RNA:DNA hybrids and innate immunity

Rigby, Rachel ElizabethThe University of Edinburgh2011

… functions of two other AGS proteins, TREX1 and SAMHD1. Therefore, no clear evidence was found for the direct involvement of RNase H2 in the innate immune response to nucleic acids. An alternative model for the pathogenesis of disease hypothesises that decreased RNase H2 activity within the cell …

edinburgh Repository record for Ribonuclease H2, RNA:DNA hybrids and innate immunity (opens in a new tab)

A nationwide survey of Aicardi-Goutieres syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study

Abe, JunyaKyoto University2014

kyoto Repository record for A nationwide survey of Aicardi-Goutieres syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study (opens in a new tab)

Using human genomics to decipher biological mechanisms underlying reproductive ageing and fertility in women

Stankovic, StasaUniversity of Cambridge2022

… also identify a new cancer predisposition gene, SAMHD1, which has a comparable effect size in women and men to well-established genes such as CHEK2, further reinforcing the link between cancer and reproductive ageing. Finally, I show that mothers with genetic susceptibility to earlier ovarian …

cambridge Repository record for Using human genomics to decipher biological mechanisms underlying reproductive ageing and fertility in women (opens in a new tab)