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Showing 1 to 2 of 2 for “"SAM metabolism"”.
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Characterization of a Novel Sensing Mechanism Governing Antigenic Variation in P. Falciparum
… had a striking impact on var gene expression. Metabolism and epigenetic control of gene expression are linked, as HMT activity is dependent on the intracellular concentrations of methyl donors, which can fluctuate based on nutrient availability. Various studies in other organisms have shown …
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SAM Homeostasis Is Regulated by CFIm-Mediated Splicing of MAT2A
S-adenosylmethionine (SAM) is the methyl donor for nearly all cellular methylation events. Cells regulate intracellular SAM levels through intron detention of MAT2A, the only SAM synthetase expressed in most cells. The N6-adenosine methyltransferase METTL16 promotes splicing of the MAT2A detained …