Global ETD Search
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Showing 1 to 6 of 6 for “"SAGA complex"”.
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Elucidating the regulation of the Yeast Metabolic Cycle through the integration of gene expression and chromatin status
… YPL254W (involved in the formation of the SAGA complex) and YLR403W (involved in the process of histones exchange), which evinced the crucial role of the acetylation levels to regulate gene expression in the YMC through a coordinated action of transcription factors and histone modification …
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Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… GSK-3 homologue Mck1 and the energy-sensing SNF1 complex, were converged to regulate starvation-induced expression of molecular chaperones, metabolic reprogramming to accumulate storage carbohydrates, activation of antioxidant defence systems, and ultimately the extension of chronological …
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Gcn5 Loss Impacts Myc-Driven Cancer In Mice and Human Cells
… subunit in the acetyltransferase module of SAGA and ATAC, multiprotein complexes involved in the modification of histone and nonhistone proteins. GCN5 is most recognized as a co-activator of gene transcription. The SAGA complex is recruited to chromatin by transcription factors such as MYC …
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Novel roles of KAT2A chromatin complexes ATAC and SAGA in normal and malignant haematopoiesis
… are often found within large multi-subunit complexes, whereby their catalytic activity is exercised. However, very little is known about how epigenetic enzymes take advantage of their participating chromatin complexes in order to accomplish their functions. In the blood system, no studies …
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Define The Epigenetic Profiles and Subtype-Specific Genes of Breast Cancer
… for H2Bub1 is USP22 in the DUB module of the SAGA complex. USP22 is the catalytic subunit of the DUB module. Two adaptor proteins, ATXN7L3 and ENY2, are necessary for DUB activity of USP22 towards histone H2Bub1 and other substrates. ATXN7L3B shares 74% identity with the N-terminal region of …
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Defining The Functions of Usp22 and Usp44 In Regulation of H2Bub1 Levels
… of the deubiquitination module (DUBm) in the SAGA complex, is a well-defined regulator of H2Bub1 levels. ATXN7, another crucial subunit of the SAGA DUBm, is involved in a neurodegenerative disease, spinocerebellar ataxia type 7 (SCA7), due to a polyglutamine (polyQ) expansion in its N-terminal …