Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"S6 kinase"”.
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Association of Protein Phosphatase 2A with S6 Kinase Is Regulated In an MTOR-Dependent Manner
… to the phosphorylation of its two substrates, S6 kinase 1 (S6K1) and 4E binding protein 1 (4EBP1) to promote translation initiation. Many reports have demonstrated the rapid dephosphorylation of S6K1 following treatment with the mTOR inhibitor, rapamycin, as well as by the depletion of amino …
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The Role of Protein Phosphatases in Regulation of Drosophila S6 Kinase by Nutrient Signaling Pathways
… act as an inhibitor of PP2A activity towards dS6K, loss of dTap conferred rapamycin resistance to S2 cells and prolonged loss of dTap resulted in cell death. I have also utilized RNAi to screen the gene products of the PP2A-like family of phosphatases and Drosophila PP2A regulatory subunits for …
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Characterization of insulin-stimulated protein kinase cascade in normal and diabetic rats and the effects of vanadium
Multiple protein kinases acting in a sequential manner have been identified to constitute a kinase cascade that mediates growth factor or mitogen-activated signal transduction. The cascade is triggered at the cell membrane by the activation of receptor tyrosine kinases, which pass on the signal in …
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REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS
… activity and upregulated acetylation of p70 S6 kinase and mTOR activation in T cells. We also found that prolonged exposure to high concentration of SCFA cause ureteral obstruction and hydronephrosis. SCFAs activated mTOR signaling in renal T cells and developed T cell-mediated inflammation …
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Insulin and TSH signal transduction pathways in human preadipocytes.
… mammalian target of rapamycin-p70 S6 kinase (p70 S6K) pathway was examined in human preadipocytes in primary culture. The inhibitory effect of rapamycin on insulin-induced differentiation of preadipose cell lines has been attributed to a blockade of clonal expansion. We demonstrate …
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Modulation of plant growth by day length dependent regulation of the TOR signaling pathway
… (photoperiod). The TOR (Target of Rapamycin) kinase pathway is a central hub where cellular energy levels are perceived and translated into specific growth responses across kingdoms. In plants, the TOR pathway has been associated with rapid growing tissue including embryos, shoot and root …
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Intracellular Signaling Contributions to Behaviors Relevant to Nicotine Addiction
… is regulated by extracellular signal-regulated kinase (ERK) signaling in the nucleus accumbens (NAc) shell or anterior cingulate cortex (PFC). ERK kinase inhibitor U0126 was infused in the NAc shell or PFC of Long Evans rats immediately prior to daily self-administration sessions and following …
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Involvement of Gdap1 In The Regulation of Mtorc1 Activity In A Drosophila Mliv Model
… levels of the mTORC1 downstream target S6 kinase (S6K) and quantified changes in synaptic growth at the larval neuromuscular junction (NMJ), which is a cell biological readout for mTORC1 activity. We found that knocking down <em>GDAP1</em> expression can partially suppress the decreased …
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The SYK tyrosine kinase suppresses autolysosome biogenesis via activation of mTORC1 in pancreatic cancer cell lines
Spleen tyrosine kinase (SYK) regulates mitogenic signaling, inflammatory responses and cell fate in a number of diverse cell types. KRAS is a proto-oncogene that controls cell growth and proliferation through several mitogenic pathways. In pancreatic cancer, KRAS is frequently mutated, resulting in …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
… a signal complex forms consisting of three kinases – B-Raf, Protein Kinase C epsilon (PKCε) and Ribosomal S6 Kinase Beta II (S6K2) – resulting in the activation of the latter. S6K2 then phosphorylates the nucleic acid binding protein Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) at …
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ATM REGULATES THE NF-kB PATHWAY VIA RELA SER 276 PHOSPHORYLATION
… (ATM), a member of the phosphatidylinositol 3 kinase-like kinase family, is a master regulator of the double strand DNA break-repair pathway after genotoxic stress. Here we found ATM serves as an essential regulator of TNF-and RSV- induced NF-kB pathway. We observed that TNF exposure of cells …
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Intramuscular Anabolic Signaling and Endocrine Response Following Different Resistance Exercise Protocols In Trained Men
… mTOR (mammalian target of rapamycin), p70S6k (ribosomal S6 kinase 1), and RPS6 (ribosomal protein S6) were not significantly different between trials. Despite significant differences in markers of muscle damage and the endocrine response following STR and HYP, both protocols appeared to …
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AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
… 간경변이나 간암으로 발전할 가능성이 높다. AMP-activated protein kinase(AMPK)는 ATP 소비와 생성의 균형을 위해서 필요한 에너지 센서 단백질이다. Hepatitis C virus(HCV)의 증식을 위해서는 AMPK의 억제와mammalian target of rapamycin(mTOR)의 활성이 필요하며 이를 통해 바이러스 복제에 필요한 지질을 합성한다. HBV X 단백질(HBx)은 mTOR의 활성을 증가시켜 hepatocellular carcinoma(HCC) 세포의 증식을 유도한다. 본 …
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Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
… and subsequently activates ribosomal protein S6 kinase 1 (S6K1). To study the role of S6K1 in hematopoiesis as well as leukemogenesis, we used a genetic model of S6K1 deficient mice (S6K1-/-). We found that loss of S6K1 expression in HSCs results in reduction of absolute HSC number in bone …
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Casein-Kinase-2-Beta und neuronale Entwicklungsprozesse
… eine durch Transposon- Insertion in den Casein-Kinase-2ß-Genlokus verursachte, hypomorphe Mutation identifiziert, die zu einer starken Verringerung der Anzahl der die Pilzkörper bildenden intrinsischen Neurone führt. Eine Reversion des mbuP1-Pilzkörperphänotyps konnte unter anderem durch die …
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Substrate Interaction and Sub-Cellular Localization in Map Kinase Pathways
Protein kinase cascades control responses to extracellular cues by transmitting signals throughout the cell. Prominent among multifunctional enzymes in kinase cascades are the mitogen-activated protein kinases (MAPKs). Among the various MAPKs identified, the extracellular signal-regulated kinases, …
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The Influence of Chromium Supplementation on the Insulin Pathway, Carcass Traits, and Meat Quality of Feedlot Steers
… activated receptor γ (PPARγ), protein kinase B (Akt), phospho- Akt, and ribosomal protein S6 kinase 1 (p70S6K) abundance and glucose transporters (GLUT) 4 and 1 gene expression. Experiment 1 showed an increase in dressing percentage (DP), KPH, and shear force, but a decrease in marbling …
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The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells
… we established the presence of a hTERT-mTOR-S6K (p70 S6 kinase)-Hsp90 (Heat shock protein 90)-Akt complex previously detected in activated NK cells in DU145 prostate cancer cells. Further, western blot analysis demonstrated that perillyl alcohol or rapamycin disrupted the binding interactions …
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The role of mTOR signaling in Alzheimer s disease
… mTOR is a ubiquitously expressed protein kinase that plays a key role in regulating protein synthesis and cell growth. mTOR also is a negative regulator of autophagy induction. By simultaneously regulating protein synthesis and degradation, mTOR is key in controlling protein homeostasis, a …
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The molecular basis for tumor growth suppression by tRNA methyltransferase 9-like (TRM9L)
… of S380 is downstream of ribosomal protein S6 kinase (RSK), which is downstream of H202-activated extracellular signalregulated kinase (ERK). TRM9L mutations S214A, S255A and S380A significantly enhanced tumor growth, while S214A and S255A mutations also abolished a direct interaction …
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