Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"S1PR3"”.
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Targeting S1PR3 to mitigate flow-enhanced invasion in the glioblastoma tumor microenvironment
… a role for the G-protein coupled receptor S1PR3 in enhancing invasion under flow. Interestingly, we found this response to be mediated by the brain parenchymal cells, astrocytes and microglia. In this work, we demonstrate clinical relevance for S1PR3 as both a biomarker and therapeutic …
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Sphingosine-1-Phosphate and Fingolimod (FTY720) Regulate ICl,swell In HL-1 Cardiac Myocytes via Intracellular Binding And Mitochondrial ROS Production
… of ICl,swell. Surprisingly, neither CAY10444 (S1PR3 antagonist; 10 μM) nor VPC23019 (S1PR1,3 antagonist; 13 μM) blocked FTY720-induced ICl,swell. Also, gallein a pan Gbeta-gamma inhibitor, failed to block the S1P-induced current. Moreover, 100 nM FTY720 applied via the pipette evoked a larger, …
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Investigating the use of omega three fish oils as protective agents against cytokine-induced skeletal muscle damage
… theratio of Sphingosine-1-phosphate receptor 3 (S1Pr3) to S1Pr1 gene expression andincreased Sphingosine Kinase 1 gene expression There were no significantinteractions of ERA and/or DMA with TGF(3, TNFa and TWEAK receptors (TGFpRII,TNFRI and Fn14 respectively).ConclusionOur findings suggest ERA …