Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"S1P1"”.
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The role of N-cadherin and S1P/S1P1 in pancreas development
… pancreas formation. S1P acts on receptors (S1P1, S1P2, and S1P3) expressed in the pancreatic mesenchyme, inducing mesenchymal growth. Studies on the S1P1 receptor knockout showed a reduced size of the dorsal pancreatic bud due to decreased proliferation of Pdx1+ cells. Other epithelial …
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
… To this end, sphingosine 1-phosphate receptor 1 (S1P1) regulates the egress of mature T lymphocytes from lymphoid organs to blood and peripheral organs. Thus, the inhibition of T cells trafficking through S1P1 receptor modulation is a potential translational approach to protect the heart in …
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The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
… p38MAPK. PANC-1 cells also contained functional S1P1 and S1P2 receptors that inhibited proliferation. Overall, a pharmacological approach demonstrated that S1P receptors regulate cancer cell proliferation, migration and signal pathways in a cell-specific manner.
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Developing Sphingosine-1-Phosphate (Spns2) Inhibitors for the Treatment of Multiple Sclerosis
… FDA approved drugs as they target primarily S1P1 receptors to achieve lower levels of circulating lymphocytes. However, targeting this receptor also results in cardiovascular side effects such as first-dose bradycardia. The transporter for S1P, spinster homolog 2 (Spns2), which is upstream of …
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Development of Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spns2 for the Treatment of Multiple Sclerosis
… (GPCRs). The binding of S1P to these receptors (S1P1-5) is closely associated with immune cell development and recruitment. As such, the modulation of S1P-related pathways is of particular interest for the development of immunomodulating agents. To reach its native GPCRs, S1P must be released …
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Structure-activity relationship studies and biological evaluation of selective sphingosine kinase inhibitors
… acts as a ligand to G-protein coupled receptors (S1P1-5). Sphingosine kinase (SphK) 1 and 2 phosphorylate sphingosine to S1P; these are the only enzymes known to mediate the phosphoryl transfer. Inhibiting either or both SphKs helps to modulate S1P, which may be useful as a therapeutic avenue for …
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The role of sphingosine kinases and dihydroceramide desaturase in regulating senescence in prostate cancer cells
… at five G protein-coupled receptors - termed S1P1-5. S1P is also an intracellular effector which binds to proteins such as HDAC1/2 and TRAF2 to elicit cell responses. Recently, other mediators in the pathway have also emerged as important mediators of autophagic, apoptotic, senescent and …
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ENDOTHELIAL- EPITHELIAL INTERACTIONS Blood vessels friends or foes?
Diabetes affects enormous amounts of patients. In type 1 diabetes the insulin producing β cells in the islet of Langerhans are destroyed by the immune system. The β cells, which are located in the pancreas, regulate blood glucose levels. The lack of insulin production requires administration of …
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Rol de los esfingolípidos en los procesos activados por estrés oxidativo en neuronas y células gliales de retina
… Existen 5 subtipos de estos últimos, denominados S1P1-5. En esta tesis, demostramos que la S1P exógena protege a los fotorreceptores de retina del daño oxidativo o de la apoptosis inducida por esfingosina a través de su receptor de membrana S1P3, puesto que el uso de un antagonista para éste …