Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"S100B"”.
-
Estudo da proteína S100B em pacientes com esquizofrenia
O projeto de pesquisa que deu origem a esta Dissertação de Mestrado foi desenvolvido em caráter colaborativo entre o Departamento de Bioquímica da Universidade Federal do Rio Grande do Sul, Departamento de Psiquiatria e Medicina Legal da Universidade Federal do Rio Grande do Sul e Serviço de …
-
The role of the astrocytic marker S100B in HIV-associated neurocognitive disorders
There are as yet no ideal biomarkers of HIV-associated neurocognitive disorders. As astrocytosis is a feature of HIV encephalitis, the marker S100β may hold promise as a biomarker of HAND. We explored associations between S100β and neurocognition in individuals with HIV in Cape Town, South Africa, …
-
Efeito do glutamato sobre a secreção da proteína S100B em cultura de astrócitos hipocampais
A proteína S100B pertence à família S100 de proteínas ligantes de Ca+2. Sua expressão dá-se primariamente em astrócitos, os quais também secretam esta proteína, exercendo um papel trófico sobre as células vizinhas. A adição de S100B tem promovido a sobrevivência de neurônios em cultura e, …
-
Marcadores periféricos de dano ao sistema nervoso central : a proteína S100B e atividades ecto-nucleotidásicas
A S100B é uma proteína ligante de cálcio, de massa molecular de 21kDa, expressa principalmente por astrócitos. Esta proteína tem sido implicada em atividades funcionais tanto intra quanto extracelulares. Muitos estudos têm sugerido que intracelularmente ela está envolvida na modulação de proteínas …
-
Clincal Aspects of Biological Brain Damage Markers
… development for some time. Recently, the S100B protein has been shown to be a promising marker of brain damage. However, before S100S can reach clinical reality, several problems must be solved. The specificity of S100B requires special investigative attention. Although the sensitivity has …
-
Alterações do conteúdo de S100B durante o desenvolvimento em tecido encefálico, líquor e cultura de astrócitos corticais de rato
A S100B é uma proteína ligante de cálcio expressa e secretada por astrócitos. Em culturas de neurônios a S100B estimula a sobrevivência e extensão de neuritos. Estudos de imunocitoquímica e hibridização do RNAm in situ indicaram um aumento pós-natal desta proteína num período coincidente com a …
-
Clinical Aspects of Pediatric Head Injury
… of introducing a brain injury marker, protein S100B, for optimizing pediatric head injury management. Paper I, a survey in 51 Swedish hospitals, shows that the management routines vary from hospital to hospital, especially concerning criteria for computed tomography, admission, and discharge. …
-
The effect of weight loss on circulating biomarkers of brain health and executive function
… fact (BDNF), S100 calcium binding protein B (S100B), and glial fibrillary acidic protein (GFAP). Serum samples (n=21; 50-75 years, BMI 25-40 kg/m2) were pooled from two prior weight loss studies. Fasting blood measurements were taken before and after 8- or 12-weeks of hypocaloric diet-induced …
-
Serum-based biomarkers and magnetic resonance imaging following mild traumatic brain injury in collegiate athletes post return-to-play
… brain injury (TBI). Proteins such as BDNF, S100B, UCH-L1, and Tau have been found to have altered levels in blood serum after TBI. However, there is limited knowledge about the relationship between serum-based and MRI-based biomarkers in concussed athletes post return-to-play. This study …
-
Biomarkers of neurological tissue injury and inflammation in paediatric tuberculous meningitis
… These were analysed with ELISA for neuromarkers S100B, neuron-specific enolase (NSE) and glial fibrillary acidic protein (GFAP), and with Luminex multianalyte array assay for a panel of inflammatory markers. Results were compared with 2 controls groups. Computerized tomography was done on …
-
Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant
… with the Ca2+-binding proteins annexin A2, S100B and the annexin A2 partner p11, together with the functional consequences of these interactions. Co-immunoprecipiation and GST-fusion protein studies show that annexin A2 binds specifically to the 5-HT2AR ct. Furthermore, annexin A2 (but not …
-
Zhodnocení výskytu a významu vybraných organických a funkčních změn centrálního nervového systému u pacientů s neurofibromatózou typ 1
… - neuron specifické enolázy (NSE) a proteinu S100B u pacientů s mozkovými gliomy. Metodika: Samostatně jsem zpracovala soubor 285 dětí s NF1, které byly sledovány na Klinice dětské neurologie UK 2. LF a FN Motol v letech 1990 - 2010. Všechny děti měly MR zobrazení mozku. Hodnotila jsem …
-
Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons: Inhibition of Neuron-Glia Gap Junction Communication and Neuropeptide Secretion
… the stimulatory effect of capsaicin on Cx 26, S100B and CGRP expression. In addition, CO2 caused a decrease in levels of SNAP-25, a protein involved in controlling CGRP release from trigeminal nerves. Results from this in vivo study provide the first evidence of a unique regulatory mechanism by …
-
Cortisol and inflammation in delirium and long-term cognitive decline after hip fracture
… of a marker of central nervous system damage (S100B) and of a dementia marker (tau) in CSF in delirium. A prospective observational cohort study was conducted in N=108 patients aged over 60 who had sustained a hip fracture, in whom 40% developed delirium. Participants gave informed consent or …
-
A Paper-Based Elisa Device for the Rapid Detection of Ischemic Stroke
… to yield a sensitive (11.8 pM) assay targeting S100B, a protein released by glial cells in the brain during stroke. Wax printing allows for creation of precise hydrophilic pathways in which sample fluid can travel within the 3D microfluidic device to react with a variety of proteins and …
-
18F-markierte S100-Proteine als potentielle Radioliganden für die funktionelle Charakterisierung des Rezeptors für advanced glycation endproducts (RAGE) in vitro und in vivo
… S100-Proteine S100A1, S100A12 und S100B in biologisch funktioneller Form hergestellt. Dazu wurden die entsprechenden S100-Gene in den prokaryotischen Expressionsvektor pGEX-6P-1 kloniert. Mit diesen Konstrukten wurden E. coli-Zellen transformiert, aus denen nachfolgend die …
-
Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin
… Cu(ll)-, and Mn(Il)-binding properties of S100B, S100A12, S100A7, S10OA15, and S100A8/S100A9. Finally, an overview of the scope of this thesis is presented. Chapter 2: Calcium Ion Gradients Modulate the Zinc(Il) Affinity and Antibacterial Activity of Human Calprotectin. Calprotectin (CP) is …
-
Exploring central and enteric nervous system vulnerability in Huntington’s Disease: hints from a knock-in animal model
… expression of pro-inflammatory markers such as S100b and IL-6 in HD enteric cultures. In vivo experiments revealed increased expression of specific Bdnf isoforms at presymptomatic stages, and elevated levels of the 55 kDa Gfap protein isoform in symptomatic-stage colonic tissue. While these …
-
The glial cell line-derived neurotrophic factor family in the olfactory system and brain
… up-regulation was noted in DA neurons as well as s100B-positive glia. The results of this study demonstrate several important features regarding GDNF family signaling mechanisms. First, RET9 was established as the main functional isoform and RET51 as a secondary receptor likely important for a …
-
DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… and stress pathways (caspase 3, caspase8, Bcl2) (S100B), inflammatory process (CCL2, NLRP3) and induce expression of both Interferon Stimulated Genes (IFITM1, IFITM3, STAT1, NFkB) and the antigen presentation pathway (ERAP1, ERAP2, HLA-A and TAP). Overall, the results obtained suggest that HCO …