Global ETD Search
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Showing 1 to 5 of 5 for “"S100A8/A9"”.
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TLR4 endogenous ligand S100A8/A9 levels in adult-onset Still’s disease and their association with disease activity and clinical manifestations
Objective: S100A8/A9 has been suggested as a biomarker of disease activity in patients with systemic juvenile idiopathic arthritis or adult-onset Still’s disease (AOSD). We investigated the clinical significance and the pathogenic role of this marker in AOSD. Materials and Methods: Serum samples …
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Systemic sclerosis. Novel molecular and epidemiological features of disease.
… of SSc. The inflammatory protein complex S100A8/A9, also known as calprotectin, has been associated with several rheumatic diseases. Faecal calprotectin (FC) is a validated biomarker in inflammatory bowel disease. We have explored the biomarker potential of FC in SSc. FC correlated with …
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Studies on anti-dsDNA Antibodies and other potential biomarkers in Systemic Lupus Erythematosus
… biomarkers, namely PNC assay, osteopontin and S100A8/A9. In paper III, the PNC assay is presented as a specific and reliable supplementary laboratory tool in the management of SLE patients. It is a functional test displaying the ability of polymorphonuclear cells to engulf necrotic cell …
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Human S100A8 and S100A9 Scavenge Pro-inflammatory Hypohalous Acids in Disease
S100A8, S100A9 and S100A12 are generally considered pro-inflammatory proteins because their expression is elevated in chronic inflammatory disorders. Hypohalous acids generated by activated phagocytes are scavenged by murine S100A8 and S100A9, suggesting a protective role in oxidative stress, but …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
… were able to produce a pro-inflammatory protein, S100A8/A9, which is increased in SLE patients (Paper II). Next we observed that the complement system and type I IFN system affect the platelets. Platelets isolated from SLE patients were more activated, had a type I IFN signature (Paper III), as …