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Showing 1 to 17 of 17 for “"S100A8"”.
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Human S100A8 and S100A9 Scavenge Pro-inflammatory Hypohalous Acids in Disease
S100A8, S100A9 and S100A12 are generally considered pro-inflammatory proteins because their expression is elevated in chronic inflammatory disorders. Hypohalous acids generated by activated phagocytes are scavenged by murine S100A8 and S100A9, suggesting a protective role in oxidative stress, but …
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TOWARDS AN IN VITRO MODEL FOR RNA INTERFERENCE- MEDIATED SUPPRESSION OF S100A8
The SI00 calcium-binding protein A8 (S100A8) has been identified as a potential genetic modifier of the lung disease of cystic fibrosis (CF) patients as well as mice. S100A8 and its heterodimeric partner, S100A9, are expressed by neutrophils and monocytes and secreted to the extracellular milieu …
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Measurement of calprotectin (S100A8/S100A9) and S100A12 in serum: method development, analytical validation, and clinical application
Background Faecal biomarkers of intestinal inflammation, in particular faecal calprotectin and to a lesser extent faecal S100A12, are used to discriminate between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and categorise active from inactive disease in established IBD. …
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TLR4 endogenous ligand S100A8/A9 levels in adult-onset Still’s disease and their association with disease activity and clinical manifestations
Objective: S100A8/A9 has been suggested as a biomarker of disease activity in patients with systemic juvenile idiopathic arthritis or adult-onset Still’s disease (AOSD). We investigated the clinical significance and the pathogenic role of this marker in AOSD. Materials and Methods: Serum samples …
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Roles of Neutrophil Activation in Asthma
… of asthma have not yet been identified. S100A8 and S100A9 are Ca2+- and Zn2+-binding proteins of the S100 family, which could be produced by lipopolysaccharide-stimulated granulocytes and provoke an innate immune-mediated airway inflammation. S100A9 protein is known to be involved in …
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A biophysical and biochemical approach to understanding the interplay between Quaternary structure and function of human calprotectin
… release calprotectin (CP), a heterooligomer of S100A8 and S100A9, from neutrophils and epithelial cells to prevent microbes from accessing manganese, iron, nickel, and zinc. CP also binds Ca(II) ions, which increases the transition-metal affinity and antimicrobial activity of CP. In addition, …
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Systemic sclerosis. Novel molecular and epidemiological features of disease.
… of SSc. The inflammatory protein complex S100A8/A9, also known as calprotectin, has been associated with several rheumatic diseases. Faecal calprotectin (FC) is a validated biomarker in inflammatory bowel disease. We have explored the biomarker potential of FC in SSc. FC correlated with …
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Proteomic Investigation of Salivary Biomarkers in Periodontal Diseases
… 1-3 (HNP 1-3), cathelicidin LL-37 and protein S100A8 were tested. Copy number variation for HNP 1-3 gene, DEFA1A3 was tested in an independent cohort and the data analysed for association with presence and degree of periodontal disease. -- Results: Antimicrobial peptides, HNP 1-3, LL-37 and …
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Studies on anti-dsDNA Antibodies and other potential biomarkers in Systemic Lupus Erythematosus
… biomarkers, namely PNC assay, osteopontin and S100A8/A9. In paper III, the PNC assay is presented as a specific and reliable supplementary laboratory tool in the management of SLE patients. It is a functional test displaying the ability of polymorphonuclear cells to engulf necrotic cell …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… transcript and protein expression of S100A7, S100A8, and S100A9 were decreased in hFWE3 and hFWE4 over-expressing cells. Transcripts for these S100 isoforms were strikingly increased in human cSCC compared to normal skin. Exposure of cSCC cells to stress stimuli including ultraviolet …
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
… were able to produce a pro-inflammatory protein, S100A8/A9, which is increased in SLE patients (Paper II). Next we observed that the complement system and type I IFN system affect the platelets. Platelets isolated from SLE patients were more activated, had a type I IFN signature (Paper III), as …
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Hematopoietic Stem Cells and Progenitors in Murine Autoimmune Arthritis
… signature" - defined by upregulation of S100a8, S100a9, Chi3l3 and SOCS3 transcripts - that is triggered not only in KSL cells but also to an even greater degree in prospectively sorted arthritic CD150+CD48-CD34-KSL LT-HSCs. Our results indicate that primitive uncommitted progenitors of …
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The identification and characterisation of proteins interacting with SUMO-ubiquitin hybrid chains
… hybrid chains. Although technically challenging, S100A8 was identified as a protein that after the action of ubiquitin and SUMO proteases shifts in a pattern consistent with that expected of a protein that may anchor a SUMO-ubiquitin hybrid chain.
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Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin
… of S100B, S100A12, S100A7, S10OA15, and S100A8/S100A9. Finally, an overview of the scope of this thesis is presented. Chapter 2: Calcium Ion Gradients Modulate the Zinc(Il) Affinity and Antibacterial Activity of Human Calprotectin. Calprotectin (CP) is a human neutrophil protein that is …
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An integrated top-down and bottom-up proteomic platform to reveal potential salivary biomarkers of the rare disorders SAPHO syndrome, Wilson’s disease and Hereditary angioedema
… to characterize new oxidized proteoforms of S100A8 and S100A9 and two fragments of the polymeric immunoglobulin receptor named ASVD and AVAD. Higher levels of these proteins and peptides observed in the patients are most likely connected to the oxidative stress, the activation of the …
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Molecular Mechanisms of Itch Sensations
… Pacsin3 and Itpr3), three histamine-dependent: S100a8, CALR and DSP) and one both-dependent: TRPV4) itch genes. Atp2a1 and Itpr3 were selected for further characterization. Atp2a1 and Itpr3 are involved in GRPR downstream Ca2+ signaling pathway for histamine-independent itch. GRPR is also …
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Mecanismos moleculares de daño y reparación durante la lesión pulmonar asociada a ventilación mecánica
… con los potentes agentes quimiotácticos S100A8 y S100A9. Hemos demostrado también que MMP-8 juega un papel deletéreo durante el desarrollo de la fibrosis pulmonar mediante el procesamiento de IL-10 in vivo, que una vez procesada pierde sus propiedades antifibróticas. El establecimiento de …