Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"S100A4"”.
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S100A4 regulation and function
S100A4 is a calcium binding and tumor associated protein. Despite its critical roles in multiple aspects of cancer progression and non-malignant disease development, the investigations on the regulation of S100A4 are limited. This dissertation focuses on exploring the mechanisms of S100A4 …
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FSP1/S100A4-expressing stem/progenitor cells are essential for TMJ growth and homeostasis
… tiivistelmä tutkimusartikkelista “FSP1/S100A4-expressing stem/progenitor cells are essential for TMJ growth and homeostasis” toimii syventävien opintojen kypsyysnäytteenä. Tutkimusartikkeli on lähetetty vertaisarvioon Journal of Dental Research -lehteen. Leukanivel on yksi kehon …
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Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects
… The aim of this study is to evaluate EMT (S100A4) and glucocorticoid receptor (TTC5 & S211) component expression in lung tissue of COPD patients and control subjects using immunohistochemical staining. The result obtained describes that S100A4 (EMT marker) was more highly expressed in …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… acquire fibrotic biomarkers such as desmin, S100A4 and α-smooth muscle actin. In lung fibrosis this has not been characterised, further the molecular mechanisms in the lung are poorly understood. Identifying these processes is key to developing improved future therapeutic interventions. …
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Functional Heterogeneity of Fibroblasts In Dermal Wound Healing
… fibroblasts in normal skin, labeled with FSP1/S100A4, acquire the myofibroblast phenotype associated with acquisition of ⍺SMA expression. Importantly, not all ⍺SMA<sup>+</sup> cells arose from FSP1/S100A4<sup>+</sup> progenitors, indicating that there exist at least two populations of …
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Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios
… incluyendo la proteína de unión al calcio S100A4, factores de crecimiento (TGFß, HGF, FGF2, FGF7, PDGFA, PDGFB, VEGFA y IGF2), citoquinas inflamatorias (IL6 y IL8), quimiocinas (CCL2 y CXCL12), proteasas (uPA, MMP2, MMP9 y MMP11), el factor de transcripción NF¿B y TIMP1. También se analizó …
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Generating Predictive Gene Expression Signatures for Alzheimer's Disease Using Postmortem Brain Tissue
… signaling pathways. Notably, upregulation of S100A4 was revealed across all regions, while CRH was downregulated in all but the cerebellum. Additionally, apolipoprotein E (APOE) genotype e3/e4 and male sex influenced disease progression while drug repurposing analysis identified FGFR …
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Towards automatic gene synthesis with bioinformatics software, novel one-step real-time PCR assembly, and lab-chip gene synthesis
… promoter of human calcium-binding protein A4 (S100A4) (752 bp) with oligonucleotides concentration of as low as 1 nM. The integrated two-step gene synthesis device is established based on the developed protocols. It is capable of performing two-step gene synthesis to assemble a pool of …
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Development of in vitro infant intestinal models to assess responses to infant formulae
… localization, and low fibroblast marker S100A4 expression. Following exposure to in vitro–digested IF, PS10-cultured IPEC-J2 monolayers exhibited increased TEER and enhanced basolateral amino acid transport, demonstrating suitability for dietary bioavailability studies in infant …