Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"S100A12"”.
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Biophysical Analysis of S100A12 and the Nucleosome Core Particle
… analogous models: the calcium binding protein S100A12 and the nucleosome core particle. These studies are unified by a shared emphasis on how physical forces govern biological function.</p> <p>In the first part, we explore calcium mediated allostery in S100A12, focusing on the distinct roles of …
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Measurement of calprotectin (S100A8/S100A9) and S100A12 in serum: method development, analytical validation, and clinical application
… calprotectin and to a lesser extent faecal S100A12, are used to discriminate between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and categorise active from inactive disease in established IBD. Faecal biomarkers have limitations including intra–individual and …
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A molecular investigation of the antimicrobial functions of the human S100 host-defense proteins
… the S100 family of proteins: calprotectin (CP), S100A12, S100A7, and S100A15. In the first half of this thesis, we elucidate the Zn(lI)-binding and antimicrobial properties of S100A12 and S100A7 through the use of solution and microbiology studies. We evaluate the affinity of S100A12 for Zn(ll), …
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18F-markierte S100-Proteine als potentielle Radioliganden für die funktionelle Charakterisierung des Rezeptors für advanced glycation endproducts (RAGE) in vitro und in vivo
… mit RAGE interagierenden S100-Proteine S100A1, S100A12 und S100B in biologisch funktioneller Form hergestellt. Dazu wurden die entsprechenden S100-Gene in den prokaryotischen Expressionsvektor pGEX-6P-1 kloniert. Mit diesen Konstrukten wurden E. coli-Zellen transformiert, aus denen nachfolgend …
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Human S100A8 and S100A9 Scavenge Pro-inflammatory Hypohalous Acids in Disease
S100A8, S100A9 and S100A12 are generally considered pro-inflammatory proteins because their expression is elevated in chronic inflammatory disorders. Hypohalous acids generated by activated phagocytes are scavenged by murine S100A8 and S100A9, suggesting a protective role in oxidative stress, but …
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Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin
… Cu(ll)-, and Mn(Il)-binding properties of S100B, S100A12, S100A7, S10OA15, and S100A8/S100A9. Finally, an overview of the scope of this thesis is presented. Chapter 2: Calcium Ion Gradients Modulate the Zinc(Il) Affinity and Antibacterial Activity of Human Calprotectin. Calprotectin (CP) is a …
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An integrated top-down and bottom-up proteomic platform to reveal potential salivary biomarkers of the rare disorders SAPHO syndrome, Wilson’s disease and Hereditary angioedema
… levels of histatins and the higher frequency of S100A12 observed in patients with respect to controls, may be connected with the dysregulation of the innate immunity and the neutrophil response typical of SAPHO syndrome. Cystatin SN abundance decrease correlated with the disease duration, …