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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"S. pyogenes"”.
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Virulence gene expression of three hypervirulent S. pyogenes M1T1 and membrane vesicles isolation
… inhibitory activity against S.pneumoniae and S.pyogenes and a potent capacity of adhesion to HEp-2 cells. The main aim of this study was to evaluate the clinical evidence of a probiotic application of S.salivarius 24SMBc for the prevention or reduction of recurrent medium otite (OM) children …
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Analysis of the molecular interplay between Streptococcus pyogenes and its human host
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. …
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Molecular and microscopical analysis of pathogenic streptococci - studies on surface proteins interacting with human cells and extracellular matrix
… the outcome of the infection. Streptococcus pyogenes (S. pyogenes), is a human pathogen mostly causing localized infections of the skin and respiratory tract, but it is also capable of causing severe invasive disease such as necrotizing fasciitis, sepsis and toxic shock. Until recently, S. …
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In-vitro-Studie über die Wirksamkeit der Bacteriocine von Streptococcus salivarius zur Inhibition von Streptococcus pyogenes
… inhibition of the human pathogenic bacterium S. pyogenes by use of a probiotic, that is in administration in New Zealand since almost four years. This probiotic named “Throat Guard” contains S. salivarius ssp. salivarius K12 and its bacteriocin Salivaricin A2 in the form of lozenges , that …
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Induction of myosin cross-reactive antibody and cytolytic T cell responses in mice with Streptococcus pyogenes
… infections in man elicited by Streptococcus pyogenes that lead to autoimmune complications in susceptible individuals. Although the underlying mechanisms for the onset of post-streptococcal autoimmunity have yet to be established, experimental information gained thus far suggests that the …
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Streptococcus pyogenes - a manipulator of human defences
Streptococcus pyogenes is a major human pathogen with more than 500 000 casualties annually of which at least 163 000 are due to invasive infections. The remainder is due to post-streptococcal complications with rheu¬matic heart disease constituting the majority. S. pyogenes also causes milder …
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Faraldsfræði Streptococcus pyogenes á Íslandi 2019-2024
Streptococcus pyogenes er einn af helstu sýkingarvöldum í mönnum og getur valdið misalvarlegum sýkingum. Í alvarlegustu sýkingunum er dánartíðnin almennt há. Bakterían býr yfir ýmsum meinvirkniþáttum sem hún nýtir sér til að komast hjá eða mæta vörnum hýsils og er M próteinið einn af mikilvægustu …
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Rgg2/Rgg3 Quorum Sensing in Streptococcus pyogenes and Innate Immune Cell Responses
… a type of innate immune cell, and Streptococcus pyogenes, an important human pathogen. In Chapter 2 of this thesis, it is shown that physiologically relevant concentrations of nitric oxide generates dinitrosyliron complexes which deplete the available intracellular iron in S. pyogenes and induces …
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Platelets and their immunomodulatory roles during Streptococcus pyogenes infection
… human disease and death worldwide. Streptococcus pyogenes is one of the major pathogens responsible for bacterial infections, which range from mild to severe and life threatening conditions. S. pyogenes contains a cell wall anchored M protein, which is an important virulence factor that can …
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Molecular studies on streptococcal surface proteins
Streptococcus agalactiae and Streptococcus pyogenes are two related human pathogens causing different diseases. This thesis focuses on a number of surface proteins expressed by S. agalactiae and S. pyogenes and, more specifically, the molecular and biological characterization of these proteins. The …
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The Convergence of Metabolism and Virulence Factor Regulation on Streptococcus pyogenes Pathogenesis
… For many pathogens such as <italic>Streptococcus pyogenes</italic>, the coordination of metabolism with the expression of virulence factors is necessary for colonization. Previous research examining the regulation of virulence factors in <italic>S. pyogenes</italic> identified a unique catabolite …
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House Fly (Musca Domestica L.) Temporal and Spatial Immune Response to Streptococcus Pyogenes and Salmonella Typhimurium: Role of Pathogen Density in Bacterial Fate, Persistence and Transmission
… survivability of GFPexpressing Streptococcus pyogenes and Salmonella typhimurium SR11 within the fly alimentary canal both spatially via epifluorescence microscopy and quantitatively via culture-recovery. Adult house flies were fed known amounts of bacteria (high or low dose), and were …
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Serotype Association and Regulation of the Hyaluronate Lyase Gene of <i>Streptococcus pyogenes</i>
<p><em>S. pyogenes</em> expresses many virulence factors, controlled by a complex regulatory network. These include hyaluronate lyase, an enzyme that degrades hyaluronic acid, a major component of the human extracellular matrix. Paradoxically, hyaluronic acid is also the sole component of the …
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Sortases: Keystones to Virulence and Targets for Anti-Infective Therapy
… pathogens, such as <italic>Streptococcus pyogenes</italic> and <italic>Staphylococcus aureus</italic>, are etiological agents of a large array of human diseases. Unfortunately, our ability to treat these infections is increasingly limited due to the development of bacterial resistance to …
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On the induction of inflammatory reactions by Streptococcus pyogenes
Streptococcus pyogenes is an important human pathogen that causes significant morbidity and mortality worldwide. In order to successfully infect the human host, S. pyogenes is equipped with tools that modulate the human immune defence. The present thesis explores how different streptococcal …
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Cell Envelope Modifications By Lcp Family Proteins Of Group B Streptococcus And Virulence Singaling By Peptides Of The Salivaricin Locus Of Streptococcus Pyogenes
… OF THE SALIVARICIN LOCUS OF STREPTOCOCCUS PYOGENES</p> <p>by</p> <p>HANNAH MORRISON ROWE</p> <p>December 2014</p> <p>Advisor: Dr. Melody Neely</p> <p>Major: Immunology and Microbiology</p> <p>Degree: Doctor of Philosophy</p> <p>Streptococci are important human and animal pathogens. Group B …
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Mechanistic insight on a chimeric Cas9 protein's specificity for DNA target with 5 '-NAA-3' PAM
… NGG discovered in wild-type Streptococcus pyogenes. While Cas nuclease engineering has largely yielded proteins with enhanced specificity for NGG and variations on G-containing PAMs, we were able to construct a chimeric Cas protein with consistent specificity for a 5'-NAA-3' PAM by …
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Phagocytosis by neutrophils - studies on phagosome dynamics and membrane traffic modulation by Streptococcus pyogenes
… microbe, but there are exceptions. Streptococcus pyogenes is one of our most common pathogens and is responsible for a wide range of diseases. Recently it has been demonstrated that these bacteria are able to survive phagocytosis by neutrophils. This doctoral thesis is about explaining those …
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Organization of the Streptococcal ExPortal and its Interaction with Cationic Antimicrobial Peptides
<p><italic>Streptococcus pyogenes<italic/> and other Gram-positive pathogens are highly dependent on secreted virulence proteins for their ability to colonize a host and evade the immune effectors that act on pathogens to prevent this. Unlike eukaryotes and Gram-negative bacteria, all Gram-positive …
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Studies of a Novel Phage Lytic Enzyme, PlySs2
… Staphylococcus aureus (MRSA) and Streptococcus pyogenes (group A streptococci – GrAS) cause potentially fatal human diseases. These are just three of the many Gram-positive pathogens for which resistance to leading antibiotics has emerged. The goal of this work was to develop a novel …
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