Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 471 for “"S. aureus"”.
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Screening for purine transporters in S. aureus
Staphylococcus aureus is an important human pathogen and crucial part of its pathogenesis depends on its ability to acquire purines to cause disease. In this study, I screened a library of individual mutants under purine import-dependent conditions by inhibiting the purine biosynthesis using the …
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In Vivo Imaging of Neutrophil Responses to Localized S. aureus Infection
Methicillin-resistant Staphylococcus aureus (MRSA) is a highly virulent, multidrug –resistant pathogen responsible for the majority of soft tissue infections. The role of neutrophils in S. aureus soft tissue infections is currently unclear. The objective of this thesis was to characterize early …
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Biophysical and Biochemical Screening Approaches for Antimicrobial Drug Discovery Targeting S. aureus ClpP
… such as Methicillin-resistant Staphylococcus aureus (MRSA) This dissertation highlights the ongoing efforts to facilitate the discovery of novel non peptidic ClpP activator compounds and improvement of pharmacological profile of existing ClpP targeting Acyldepsipeptides (ADEPs) series …
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Studies on the Maturation of Secreted Quorum Sensing Peptides That Regulates S. Aureus Virulence
… in the commensal human pathogen, Staphylococcus aureus, is a two-promoter operon with allelic variability that encodes a quorum sensing circuit involved in regulating virulence in the bacterium. Secretion of unique autoinducing peptides (AIPs) and detection of their concentration via AgrC, a …
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The relationship between S. aureus biofilm properties, inflammation, and disease severity in chronic rhinosinusitis
… different inflammatory clusters. Staphylococcus aureus mucosal biofilms are associated with severe recalcitrant CRS. However, S. aureus colonisation of the nose and paranasal sinus mucosa is also frequent in the absence of mucosal inflammation. This questions the relevance of S. aureus biofilms …
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Daptomycin versus Vancomycin for Empiric Treatment of Methicillin-Resistant S. aureus among Hospitalized Patients: An Institutional Cost-Breakpoint Analysis
… caused by methicillin-resistant Staphylococcus aureus is associated with increased hospitalization days, costs, and mortality. Daptomycin was shown to be noninferior to vancomycin in a phase III clinical trial; however the study was limited by low rates of MRSA infection and before the emergence …
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Patterns and Predictors of HIV, Sexually Transmitted Infections, and Staphylococcus Aureus Co-Infection among New York State Prison Inmates
… diseases. At the same time, Staphylococcus aureus (S. aureus) colonization and infection rates are elevated in these settings. Moreover, HIV and sexually transmitted infections (STIs) are also prevalent. The purpose of this cross-sectional, correlational secondary analysis was to describe …
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Elucidating the contributions of superoxide dismutases to staphylococcus aureus pathogenicity
… One disease-causing organism is Staphylococcus aureus. Despite numerous methods used by the host immune system to combat infection, S. aureus is still a major health risk. Recently, the Centers for Disease Control and Prevention and the World Health Organization listed S. aureus as one of the …
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Genomic insights into the host range and interspecies transmission dynamics of Staphylococcus aureus
Staphylococcus aureus is an important human bacterial pathogen with a wide host range, including livestock, companion, and wild animal species. Genomic and epidemiological studies show that S. aureus can freely transmit between different species, with some of these transmissions resulting in …
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Staphylococcus aureus as a source of antigens stimulating bovine dendritic cells and lymphocytes in vitro
Staphylococcus aureus (S. aureus) is a gram-positive bacterium that causes mastitis in bovines and leads to financial losses to the dairy industry. Although antibody response plays a role in immune defense against S. aureus, cellular responses are of interest for vaccine development. A vaccine that …
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Application of Essential Oil Compounds and Bacteriophage to Control Staphylococcus aureus
<p>Staphylococcus aureus is one of the most important pathogens, causing various diseases in humans and animals. In addition, S. aureus is a common foodborne pathogen. As methicillin- resistant S. aureus (MRSA) becomes increasingly prevalent, controlling this pathogen in animals and humans with …
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Analysing M. abscessus-macrophage interactions and investigating treatments for M. abscessus and S. aureus intracellular bacterial infections, using a continuously growing, primary cell model of lung alveolar macrophages
… Mycobacterium abscessus (MAB) and Staphylococcus aureus (SA) are bacterial pathogens capable of causing a range of infections in humans, and pulmonary infections are significant amongst them. During pulmonary infection, alveolar macrophages (AMs), as sentinel immune cells of the airways, are key …
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MOLECULAR SUBTYPING OF STAPHYLOCOCCUS AUREUS ISOLATES FROM THE U.P. COMMUNITY FOR THE PRESENCE OF TOXIN-ENCODING GENES
<p><em>Staphylococcus aureus</em> is the most common cause of human bacterial infections; however, humans can also be asymptomatically colonized with <em>S. aureus</em>. Asymptomatic carriers can potentially spread <em>S. aureus</em> infection to others. These infections can range from mild to …
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Monocyte Derived Dendritic Cells: Sentinels and Translators of Immune Response to Staphylococcus aureus
<i>Staphylococcus aureus</i> is a versatile opportunistic pathogen causing a wide spectrum of diseases in both humans and animals. My research focused on characterization of the immune responses of monocyte derived dendritic cells (DC) to <i>S. aureus</i>. We initially evaluated the potential of …
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Investigation of the role of Staphylococcus Aureus toxins in a cartilage explant model of septic arthritis
… of inducing septic arthritis, Staphylococcus aureus is most commonly implicated, accounting for up to 65% of cases. Whilst this organism is known to produce a diverse array of potential virulence factors, studies investigating a variety of S. aureus-related infections have implicated …
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Staphylococcus aureus small colony variants use heme and staphyloferrin B for iron acquisition
… nutrient for the bacterium Staphylococcus aureus. Wild-type S. aureus utilizes various iron acquisition systems to support growth in iron deplete conditions. S. aureus small colony variants (SCVs) are associated with chronic infections, yet the mechanisms by which these variants acquire …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… levels change over the whole growth curve of S. aureus, from senescence to logarithmic growth and back to senescence. We first extended our established ion-pairing agent-based LC-MS/MS method for detecting UDP-linked intermediates, including energy-rich nucleotides (ATP, etc.) (unpublished). In …
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Characterisation of lipoproteins in staphylococcus aureus
The Gram-positive bacterium Staphylococcus aureus is an extremely successful opportunistic bacterium capable of causing a wide range of hospital-acquired and community-acquired infections, and is becoming increasingly virulent and resistant to antibiotics. In order to investigate this pathogen, …
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Modulation of Innate Immune Cell Signaling Pathways by Staphylococcus aureus and Omnigen-AF®
Staphylococcus aureus causes chronic mastitis in bovines that is difficult to treat with current therapeutics. The goal of this research is to provide information about and improve innate immune responses to infection. Infection can result in host cell apoptosis or programmed cell death. Many …
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Carriage rate of staphylococcus aureusamong healthcare workers at the University Teaching Hospital in Lusaka
Staphylococcus aureus is a frequent cause of hospital-acquired infections worldwide. The carriage of S. aureus among healthcare workers has been associated with transmission of the bacterium to susceptible patients. The aim of this study was to determine the carriage rate, antimicrobial …
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