Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"S. Typhi"”.
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Genomics and host response of S. Typhi infections
Abstract: Genomics and host response to S. Typhi infections Mailis Maes, Department of Medicine, St. Edmunds College, University of Cambridge Around 20 million people are diagnosed annually with typhoid fever, caused by the Gram-negative bacterial pathogen Salmonella enterica serovar Typhi (S. …
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A Genetic Analysis of the Salmonella Typhi Host Range
Genetic hybrids of S. typhimurium-S. typhi constructed by P22-mediated transduction remain unable to expand the host range of S. typhi to include mice. However, construction of genetic hybrids is useful for identifying linkage discontinuities between these species that are undetectable by other …
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The Regulation of Salmonella Typhi Vi Capsular Antigen Expression in Intestinal Model Epithelia and the Bovine Ligated-Ileal Loop Model
Salmonella enterica serovar Typhi, a major public health concern in developing countries, continues to be a priority for the World Health Organization. S. Typhi possesses a viaB locus responsible for the biosynthesis of the Vi-capsular antigen, a significant virulence factor at the focus of …
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The molecular epidemiology of Salmonella Typhi and applications for policy
Salmonella Typhi (S. Typhi) is a Gram-negative bacterium and the etiologic agent of typhoid fever. High rates of typhoid were historically associated with urban slums in South Asia with poor sanitation, but recent multicentre surveillance studies have demonstrated that typhoid is also a major …
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Modelling the interactions of Salmonellae with the human host using stem cell-derived intestinal organoids and macrophages
… a particular host. Salmonella enterica serovar Typhi (S. Typhi) and Salmonella enterica serovar Paratyphi A (S. Paratyphi A) cause typhoid and paratyphoid fevers respectively, which are collectively associated with ~25 million cases and 250,000 deaths per year, predominantly concentrated in …
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Natural Genetic Variants in Humans and Salmonellae Underlie Variable Infection Outcomes
… the world and measured S. enterica serovar Typhi (S. Typhi) replication inside these human cells as a proxy for virulence in a whole person. We then associated this quantitative outcome with more than 10 million genetic markers in the genotyped cell lines to identify specific loci that …
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Replication and stability of the linear plasmid pBSSB2
… flagellar antigen in Salmonella enterica serovar Typhi (S. Typhi) isolated from Indonesia. Together with the H: j or H: d flagellar antigen encoded by the host chromosome, pBSSB1 renders expression of the flagellar antigen biphasic in S. Typhi. Following the discovery of pBSSB1, initial …
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Development of novel conjugate vaccines against Salmonella
… protection against S. enterica serovar Typhi, the causative agent of human typhoid. Unfortunately, these typhoid vaccines are only moderately immunogenic in infants and young children and revaccination is required every few years. Therefore, new vaccines are needed, which not only confer …
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ENGINEERING PHAGE HOST RANGE PROMISCUITY
… this viral group (the Vi01 phage) in Salmonella Typhi has been identified as the Vi capsular polysaccharide (CPS). This study aimed to develop a promiscuous phage receptor expression system allowing infection in a broad range of heterologous hosts. The S. Typhi Vi CPS biosynthetic operon was …
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Towards Accessible Diagnostics: Developing CRISPR-Based Colorimetric Tools for Low- and Middle-Income Countries
… and screening of 48 gRNAs specific for S. Typhi were conducted considering various reaction parameters. The results were compared to existing gRNA prediction models. The findings revealed significant variability in gRNA performance, highlighting the limitations of current sequence-based …
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Bacteriophage Felix O1: Genetic Characterization and Bioremedial Application
… BHI cultures indicated greater suppression of S. typhi by LP than by WT, a difference not seen with S. typhimurium DT104. Both isolates suppressed 24-hour S. typhimurium DT104 growth on experimentally-contaminated chicken frankfurters at 22°C. Untreated frankfurters yielded 6.81 log10 Salmonella …
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Phytochemical screening and antibacterial testing of selected Namibian medicinal plants against laboratory and clinical bacteria that cause Diarrhoea
… against laboratory strains of S. boydii and S. typhi however it showed no antibacterial activities against clinical strains of Shigella and Salmonella. Organic extracts of T. sericea and C. apiculatum also showed a lowest Minimum inhibitory concentration (MIC) of 250 μg/ml against E. coli and …
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Investigating the DNA damage response induced by Typhoid Toxin
… resistant human pathogen Salmonella Typhi that causes 27 million cases of typhoid fever per year and chronic infections, which retain the pathogen in the population. The toxin is secreted by intracellular Salmonella into the extracellular milieu from where it enters bystander cells …
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Disease Surveillance and Implications on Public Health Decisions: Example of invasive Salmonellosis in sub-Saharan Africa
… analysis to investigate the different *S*. Typhi strains circulating in Madagascar for the past ten years, and participated in updating the pan-African *S*. Typhimurium phylogenetic tree. Findings from these work can have significant potential impact on public health as they show how such …
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Developing a guide for baseline salonella agglutinin titres according to age, gender and HIV status in patients attending at hospitals in northern Namibia.
… by Widal agglutination technique. Standard S. typhi O and H and Salmonella paratyphi AH and BH suspension (FORTRESS) were used as antigens. This study reports that Typhi O and Typhi H titres greater than 80 are diagnostic of typhoid fever in the studied population regardless of age, gender and …
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Phytochemical, biological and toxicity studies of terminalia sericea burch. (Combretaceae)
… Pseudomonas aeruginosa (ATCC 27858), Salmonella typhimurium (ATCC 14028), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12223) and Shigella sonnei (ATCC 9292). The pure compound (sericic acid) was highly active against S. sonnei (MIC 0.078 μg/mL), a Gram- negative …