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Showing 1 to 7 of 7 for “"S-palmitoylation"”.
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Chemical Tools for Exploring IFITM3 S-Palmitoylation and Mechanism
<p>Protein S-palmitoylation is a reversible post-translational lipid modification that regulates the trafficking, stability, and activity of proteins in eukaryotes. The detection of fatty-acylated proteins has been challenging but recent advances in chemical labeling methods have enabled more …
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Dhhc5 Regulates Beta-Adrenergic Signaling In The Heart Through Palmitoylation of G Alpha Proteins
<p>S-palmitoylation is a reversible posttranslational modification that plays an important role in regulating protein localization, trafficking, and stability. Recent studies have shown that some proteins undergo extremely rapid palmitoylation/depalmitoylation cycles after cellular stimulation …
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Repulsive cues and signalling cascades of the axon growth cone
… donor. Coupled with its apparent relation to Spalmitoylation, the reciprocal of S-nitrosylation, I propose that nitric oxide causes collapse by crossing the cell membrane to inhibit S-palmitoylation–determined localisation of proteins. These results reveal some of the many pathways involved in …
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Develoment and Application of Chemical Strategies to Study Protein Fatty-Acylation in Eukaryotes
<p>Reversible S-palmitoylation confers spatiotemporal control of protein function by modulating protein stability, trafficking and activity as well as protein-protein and membrane-protein associations. While it is evident that palmitoylation is regulated in vivo, mechanisms that mediate cellular …
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DHHC PROTEIN ACYLTRANSFERASES CATALYZES THE LYSINE PALMITOYLATION OF MEMBERS OF THE RAS SUPERFAMILY OF SMALL GTPASES
… to the side chain of an amino acid. Cysteine palmitoylation or S-palmitoylation is best understood and widespread post-translational modification in this class, followed closely by N-terminal glycine myristoylation and lastly by O-serine fatty acylation. In recent years, a previously …
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Characterisation of the cell-surface localised palmitoyl acyl transferase, DHHC5
S-Palmitoylation is the reversible addition of 16-carbon fatty acids onto cysteine residues of proteins. The functional consequences of palmitoylation are diverse and it has been demonstrated to play a critical role in several physiological and disease pathways. DHHC palmitoyl acyl transferase …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
<p>Lipidation of proteins regulates many cellular processes such as signaling transduction and membrane sorting by modulating protein localization and proteinprotein interactions. As such, defects in protein lipidation can render host cells more susceptible to microbial infection and are also …