Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"S-acylation"”.
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Enzymology of DHHC-mediated Protein S-Acylation
Protein <italic>S</italic>-acylation is the post-translational modification of proteins with long-chain fatty acids at cysteine residues via a thioester linkage. The most commonly attached lipid is 16-carbon palmitate, thus the process is often called palmitoylation. Unlike other lipid …
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Investigating the mechanisms and outcomes of Sprouty-2 S-acylation
S-acylation is a reversible post-translational modification (PTM) that regulates proteins in several ways, including by modulating trafficking, stability and protein interactions. This PTM is mediated by twenty-three zinc finger DHHC (zDHHC) enzymes that display distinct activity and substrate …
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Lysophosphatidylcholine acyltransferase-2 (LPCAT-2) & protein S-acylation in macrophage innate immunity
… has been reported that LPCAT1 can catalyse the acylation of histone proteins. The addition of lipid groups to a protein can impact membrane-protein association, protein structure and protein stability ultimately affecting a proteins function. This gave rise to the main research question explored …
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S-Acylation Is A Key Regulator of Orai1/Stim1-Mediated Store-Operated Calcium Entry In T Cells
… demonstrated that both Orai1 and STIM1 require S-acylation to form active CRAC channels and mediate SOCE. Lastly, our studies using total internal reflection fluorescence microscopy showed that a lack of S-acylation of either Orai1 or STIM1 resulted in significantly reduced Orai1/STIM1 …
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Bioorthogonal Chemical Reporters Reveal Fatty-Acylation of Histone H3 Variants and Cholesterol Modification of Proteins and Trafficking in Cells
… on the conserved cysteine 110, a novel site of S-acylation on histone H3.2. This newly discovered modification of histone H3 variants could have implications for nuclear organization and chromatin regulation. Cholesterol is an abundant sterol in the membranes of higher eukaryotes that is important …
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Non-Lysine Acyl Modifications and Their Effects on Cellular Function
… reactivity of metabolites, non-enzymatic protein acylation, and possible signaling roles for these metabolites. Previously HMG-CoA was identified as a reactive metabolite that non-enzymatically modifies proteins when its utilization is blocked. We investigated whether statins, which inhibit the …