Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 263 for “"S Phase"”.
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Controls Over S-Phase And Over Nuclear Synchrony
… pombe, we have investigated the controls over S-phase within the cell cycle and over S-phase and mitosis among multiple nuclei within a common cytoplasm. To achieve faithful replication of the genome in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from …
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S-phase checkpoint activity and function throughout the cell cycle
DNA damage or replication stress during S-phase can activate the S-phase checkpoint which executes a variety of responses, such as the inhibition of origin firing and replication fork stabilisation. Deregulation of the S-phase checkpoint leads to genomic instability, which has been implicated in …
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Human cohesin dynamics and their regulation in M and S phase
… together from the time of their generation in S phase until their separation in M phase, thus ensuring the fidelity of mitosis. The complex mediates this so-called cohesion by topologically embracing the sister chromatids inside its ring structure composed of the three subunits Scc1, Smc1 and …
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Control of Replication Fork Stability by Chromatin and S-phase Checkpoint
La información genética debe permanecer inalterada en el ADN para el correcto funcionamiento celular. Sin embargo, el ADN está expuesto a diversas fuentes de daño que pueden generar inestabilidad genómica. Entre las lesiones más comunes se encuentran los cortes de cadena sencilla. Sin embargo, los …
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The role of Cdc7 and cyclin-dependent kinases in DNA replication and S phase
… stability. DNA replication takes place during S phase to faithfully duplicate a cell’s genetic material. In eukaryotes, S phase onset involves the initiation of numerous licensed replication origins across the genome and requires the activities of two protein kinases, S phase-Cdk and Cdc7. In …
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Increased Rate and Extent of the P53 Dna Damage Response During S-Phase of the Cell Cycle
… of p53 is activated prior to or during early S-phase in healthy cells. Because this is not what one would expect from a gene involved in growth arrest and apoptosis, we hypothesized that this is happening to provide mRNA (but no active protein) in order to prepare for DNA damage in S-phase, …
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Phosphorylation of the replicative helicase by the S-phase kinase, Dbf4-Cdc7, at origins of replication in Saccharomyces cerevisiae
… of origins occurs in late M- and early Gl-phase and is mediated by the origin DNA-binding protein called the Origin Recognition Complex (ORC). ORC recruits several proteins to the DNA, including the Mcm2-7 replicative helicase, to form the pre-Replicative Complex (pre-RC). Origins are …
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Identification of a novel role for Eb1 in the regulation of cell growth and G1-S phase progression in Drosophila / by Deborah Coates.
This thesis aimed to characterise the G1-S phase role of Drosophila Eb1, dEb1, which was identified in a cyclin E genetic screen. A dominant modifier screen was undertaken to identify novel regulators of cyclin E, and cell cycle progression using a hypomorphic allele of cyclin E. One suppressor …
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Regulation of DNA replication by PP2A family phosphatases
… genome instability, characteristics of cancer. S phase Cyclin-dependent kinase (S-CDK) plays a dual role in this regulation both by restricting helicase loading (licensing) to G1 phase, and by activating origin firing in S phase. The essential S-CDK phosphorylation of the limiting initiation …
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Analysis of Interphase Chromatin Motion in HeLa Cells
… techniques were used to characterize interphase chromatin mobility in the cell nucleus. Interphase chromatin undergo replication prior to cell division with the assistance of replication proteins (machinery) which modify chromatin mobility. Using dual color imaging of flourescently tagged …
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Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins
… endo cycle. The endo cycle consists of only S phase and a gap phase, leading to polyteny. It is preceded by the first detectable G1 period in Drosophila embryogenesis and developmentally regulated induction of S phase genes in the pattern of DNA synthesis. My analysis of the regulation of G1-S …
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Cell cycle parameters and sweet corn emergence and seedling vigor
… was observed for all of the cell division cycle phases which include G1, S, and G2. The S phase, when cells are undergoing DNA replication, showed the closest association to seedling growth. Inbred lines homozygous for starchy (Su1) endosperm displayed a significantly higher proportion of nuclei …
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Cell Cycle Progression Effects of Albumin
<p>Progression through G<sub>1</sub> phase of the cell cycle is controlled largely by growth factors in early G<sub>1</sub> and by nutrients in late G<sub>1</sub> indicating sufficient raw material for cell division. We previously mapped a late G<sub>1</sub> cell cycle checkpoint for lipids …
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Strength modelling of Al-Cu-Mg Type alloys
… Al-Cu-Mg alloys with compositions in the (?+S) phase region. Experiments by means of hardness and tensile tests, differential scanning calorimetry and transmission electron microscopy (TEM) have been carried out to provide the relevant information for the calibration and validation of the model. …
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Role of WD domain-containing proteins in cell cycle progression
… which licensed the origins prior to entering S phase. Unlike yeast, replication origins in higher eukaryotes do not have consensus sequence and metazoan ORC does not bind to DNA in a specific manner. Thus, a long-standing question in the field has been, how are origins specified and how are ORCs …
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Replication of bovine parvovirus
… cycling cells is produced during early or mid S phase. Due to this S phase dependence, parvoviruses replicate synchronously only in synchronized cells. This study was initiated in order to determine the kinetics of replication of BPV in highly synchronized cells, the effects of viral replication …
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Cellular factors and viral elements for parvovirus replication
… parvovirus (BPV), need a factor present at the S-phase of the cell cycle for a productive infection, while dependent parvoviruses, the adenoassociated viruses (AAVs), require a helper virus to complete an infectious cycle. However, AAV can replicate autonomously in synchronized cells, suggesting …
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Effects of Homocysteine on Cardiac Neural Crest Cell Formation
… (BrdU) was used to label cells in S- phase of the cell cycle. In control embryos, a significantly higher percentage of newly formed NC cells were in S-phase compared to migrating NC cells or their progenitors within the neural tube. These results parallel those of other investigators …
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Cell cycle regulation of complex formation at origins of DNA replications
This suggests that the S phase cyclin, which first activates DNA replication, then acts locally at the origin to prevent pre-RC formation.
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The in vivo proliferation kinetics of human solid tumours
… to measure in vivo the duration of cell cycle phases has been severely handicapped by the need to use radioisotopes and to take sequential biopsies. The drug 5-bromo-2-deoxyuridine (BRdU) is a safe, ethical alternative to tritiated thymidine for in vivo labelling of DNA during the S phase of …
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