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Showing 1 to 20 of 46 for “"Ryanodine receptor"”.

  1. Ryanodine receptor expression in trophoblasts

    Zheng, LimianUniversity College Cork2013

    … is essential in fetal skeleton formation. Ryanodine receptors (RyRs) are high conductance cation channels that mediate Ca2+ release from intracellular stores to the cytoplasm. To date, the roles of RyRs in trophoblasts have not been reported. By use of reverse transcription PCR and western …

    cork Repository record

  2. Catecholamine Interactions with the Cardiac Ryanodine Receptor

    Klipp, Robert Carl

    portland-state Repository record

  3. Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin

    Grillo, Michael AnthonyUniversity of Missouri--Kansas City2013

    … show that calsenilin directly interacts with the ryanodine receptor (RyR) modulating Ca2+ release from this intracellular Ca2+-activated Ca2+ release channel. Co-expression, co-localization, and protein-protein interaction of calsenilin and RyR in primary neurons and in central nervous system …

    umkc Repository record

  4. Expression and functional analysis of murine ryanodine receptor type 3

    Bertocchini, FedericaThe Open University2000

    Ryanodine receptors (RyRs) are intracellular homotetrameric Ca<sup>2+</sup>-release channels constituting a family of three different isoforms, named RyRl, RyR2 and RyR3. RyRl and RyR2 are highly expressed in skeletal and cardiac muscles respectively, where they localize in the terminal cisternae …

    the-open-u Repository record

  5. In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle

    Li, Linwei2014

    … store, the Sarcoplasmic Reticulum (SR), through Ryanodine receptor Ca2+ release channels (RyRs). In the resting state, striated muscle requires a tight control of Ca2+ release through RyRs. Another SR bound protein, junctin, is thought to facilitate this. Located in both skeletal and cardiac …

    aus-cath Repository record

  6. In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle

    Li, Linwei2014

    … store, the Sarcoplasmic Reticulum (SR), through Ryanodine receptor Ca2+ release channels (RyRs). In the resting state, striated muscle requires a tight control of Ca2+ release through RyRs. Another SR bound protein, junctin, is thought to facilitate this. Located in both skeletal and cardiac …

    anu Repository record

  7. Functional Importance of Oxidative Post-Translational Modifications of Ryanodine Receptor in Cardiac Sarcoplasmic Reticulum Ca2+ Handling During Oxidative Stress

    Mazurek, Stefan R.2016

    … that initiates muscle contraction in the heart. Ryanodine receptor (RyR2) acts as the primary Sarcoplasmic Reticulum (SR) Ca2+ release channel in the heart. In the event that intracellular SR Ca2+ handling is compromised, both the contractility and electrical excitability of the heart can be …

    loyola-thes Repository record

  8. Malignant hyperthermia: allele specific expression and mutation screening of the ryanodine receptor 1 : a dissertation presented to Massey University in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry

    Grievink, Hilbert2009

    massey

  9. Cholinergic Regulation of Circadian Rhythms in the SCN: Characterization of Signaling Mechanisms and the Role of Intracellular Calcium in the Directionality of Clock Resetting

    Artinian, LianaUniversity of Illinois at Urbana-Champaign2015

    … cholinergic phase advance, while InsP3 , but not ryanodine, receptor antagonists block it. In contrast, selective activation of CICR with ryanodine results in glutamate-like delay. Ca 2+ imaging using multiphoton microscopy revealed signal-specific differences in Ca2+ transients. …

    uiuc Repository record

  10. Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model

    Santiago, Jason2001

    … One indispensible Ca2+ signaling protein is the ryanodine receptor (RyR) calcium release channel. RyR1 is essential for muscle contraction, and RyR1mutations can lead to severe muscle disorders such as malignant hyperthermia (MH). Recently, a mouse model of human MH (Y522S-RyR1) has been …

    denver Repository record

  11. Quercetin and chloroquine synergistically induces cell death in glioma cells via the increase of Ca2+ and ROS levels

    이, 주안2014

    … CQ was effectively inhibited by dantrolene (a ryanodine receptor antagonist) and RU-360 (an inhibitor of mitochondrial uniporter), suggesting that the release of Ca2+ from the endoplasmic reticulum and mitochondria Ca2+ influx may be critically involved in this cell death. In addition, combined …

    ajou Repository record

  12. The effects of Tumour necrosis factor-alpha and Interleukin-1-beta on intracellular calcium handling and contractility in sheep ventricular myocytes

    Hadgraft, N2026

    … model then investigated their effects on the ryanodine receptor (RyR) and myofilament sensitivity to calcium.Sheep ventricular myocytes were used for all experiments. All procedures used accord with the Animals (Scientific Procedures) Act, UK, 1986 and Directive 2010/63/EU of the European …

    salford Repository record

  13. Circadian rhythms of redox state and regulation of neuronal excitability in suprachiasmatic nucleus of rodents

    Wang, TongfeiUniversity of Illinois at Urbana-Champaign2012

    … to excitatory neurotransmission, targeting on a ryanodine receptor–dependent intracellular Ca2+ store. Our study provides a novel pathway for the metabolic oscillator to engage in the organization with the central circadian clock; it couples the molecular clockwork and cellular energetics with …

    uiuc Repository record

  14. Yeast two-hybrid analysis of skeletal muscle triad junction proteins

    Proenza, Catherine, author, Beam, Kurt G., advisorColorado State University. Libraries1999

    … was detected between the dihydropyridine receptor (DHPR) II-III loop and the skeletal muscle ryanodine receptor (RyR); however, a possible weak interaction between physiologically important parts of the two receptors was investigated. In screens of a skeletal muscle cDNA library, no …

    colostate Repository record

  15. Spring Forward or Fall Back? Redox State as a Determinant in Glutamate Signaling Pathways Adjusting Our Brain Clock

    Yu, YanxunUniversity of Illinois at Urbana-Champaign2015

    … downstream of glutamate have been identified as ryanodine receptor (RyR) and soluble guanylate cyclase (sGC), in the early night and late night, respectively. However, the determinant of this signaling-pathway bifurcation remains unknown. I tested the hypothesis that cellular redox state …

    uiuc Repository record

  16. Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells

    Su, ZijunThe University of Western Ontario2017

    … we reveal that up-regulation of JPH2 reduces ryanodine receptor-2 (RyR2)-mediated SR Ca2+ leak and inhibits calcium-dependent calpain activation in H/R-stimulated cardiomyocytes. Lastly, up-regulation of JPH2 prevents endoplasmic reticulum stress in response to H/R. In summary, we demonstrate …

    uwo Repository record

  17. Modulation of calcium signalling in human sperm by nitric oxide

    Machado de Oliveira, Gisela Sofia MendesUniversity of Birmingham2008

    … in human sperm, by a mechanism involving ryanodine receptor (RyR) activation. Pre-treatment with NO reduced the amplitude of the Ca\(^{2+}\) response to ryanodine (a RyR agonist), suggesting convergence of the actions of NO and ryanodine. Sperm pre-treatment with NO greatly enhanced the …

    birmingham Repository record

  18. Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects

    Lopez, Adam AndrewUniversity of Missouri--Kansas City2020

    … the correction of calcium imbalance caused by ryanodine receptor malfunction. The estrogen receptor is thought to elicit this estrogenic protection by acting as a nuclear transcription factor and increasing the expression of anti-apoptotic proteins. However, the estrogen receptor also has …

    umkc Repository record

  19. Cell coupling and exocytosis measured in intact mouse pancreatic islets Control of {delta}-cell secretion

    Zhang, QuanDepartment of Clinical Sciences, Lund University2008

    … from Ca2+-induced Ca2+-release (CICR) via ryanodine receptor 3 (RyR3). Both somatostatin release measurements and patch-clamp experiments indicate that R-type Ca2+-channels are tightly coupled to CICR. The latency between Ca2+-influx through R-type Ca2+-channels and CICR was <6 ms. However, …

    lund Repository record

  20. Changes in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure

    Allen, Emily E.Virginia Tech2002

    … proteins involved in calcium release are the ryanodine receptor (RyR) and the dihydropyridine receptor (DHPR). The main proteins involved in calcium uptake are the fast and slow isoforms of sarco(endo)plasmic reticulum calcium ATPase (SERCA 1 and SERCA 2 respectively). Calsequestrin (Csq) and …

    vt Repository record

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