Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Ryanodine Receptors"”.
-
Ryanodine receptors in calcium signaling pathways
… of Ca<sup>2+</sup> being highly toxic.</p><p>Ryanodine receptors (RyRs) and inositol trisphosphate receptors (IP<sub>3</sub>Rs) are Ca<sup>2+</sup> -release channels located on intracellular membranes of the endoplasmic reticulum (ER)/sarcoplasmic reticulum (SR) that perform essential …
-
Presenilins Modulate Cellular Activity of Ryanodine Receptors
… J., Presenilins Modulate Cellular Activity of Ryanodine Receptors. Doctor of Philosophy (Biomedical Sciences), December, 2012, 160 pp., 7 tables, 39 figures, bibliography 241 titles. Ryanodine Receptors (RyRs) are large, endoplasmic reticulum (ER) intracellular calcium channels in excitable …
-
The role of Ryanodine receptors in neuronal calcium signaling
… the cells.</p><p>Inositol-1, 4, 5-trisphosphate receptors (IP<sub>3</sub>Rs) and ryandine receptors (RyRs) are the most studied Ca<sup>2+</sup> release channels located on the internal stores. Previous studies have shown ryanodine receptors (RyRs) play a key role in the process of Ca<sup>2+</sup> …
-
Role of ryanodine receptors in neuronal calcium signalling and growth control
… Ca<sup>2+</sup> influx pathway. Agonists of the ryanodine receptor (RyR); chlorom- cresol (CMC), polychlorinated biphenyl 95 (PCB), ryanodine, caffeine, and that of the inositol-1 ,4 ,5-trisphosphate receptor (IP<sub>3</sub>R), bradykinin, effectively couple to the activation of Ca<sup>2+</sup> …
-
THE ROLE OF ATP AND FK-506 BINDING PROTEIN IN THE COUPLED GATING OF SKELETAL RYANODINE RECEPTORS
… sparks originate from groups of skeletal ryanodine receptors (RyR1) that activate and close in synchrony. This synchrony allows for the rapid and massive release of Ca<super>2+</super> from the sarcoplasmic reticulum to initiate contraction and, more important, would provide a mechanism to …
-
The role of intracellular Ca2+ in the arrhythmogenic activity of pulmonary vein cardiomyocytes
… from the sarcoplasmic reticulum through the ryanodine receptors, immunocytochemistry was used to determine their distribution. The ryanodine receptors were arranged in a striated pattern with some distribution at the periphery of the cells, which was similar to myocytes from the atria. When …
-
CaV3.2 Channels and BKCa-Mediated Feedback in Vascular Smooth Muscle
… little is known of its regulation and how key receptors and signaling pathways use this channel to influence tissue perfusion. This thesis will begin to fill key knowledge gaps, undertaking experiments that progress from individual smooth muscle cells to whole arteries, and which entail the use …
-
Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
… the correction of calcium imbalance caused by ryanodine receptor malfunction. The estrogen receptor is thought to elicit this estrogenic protection by acting as a nuclear transcription factor and increasing the expression of anti-apoptotic proteins. However, the estrogen receptor also has …
-
A quantitative study of neuronal calcium signaling
… release from the endoplasmic reticulum via IP3 receptors which includes diffusion of calcium and IP3 as well as calcium buffering by the mitochondria results in a calcium wave similar to what has been observed experimentally. Finally, I use a branch structure together with IP3 generation, …
-
Ryanodine receptor expression in trophoblasts
… is essential in fetal skeleton formation. Ryanodine receptors (RyRs) are high conductance cation channels that mediate Ca2+ release from intracellular stores to the cytoplasm. To date, the roles of RyRs in trophoblasts have not been reported. By use of reverse transcription PCR and western …
-
T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
… kinases. In particular, β-adrenergic receptors and downstream activation of protein kinase A selectively inhibited CaV3.2 currents. Nitric oxide additionally suppressed CaV3 channels through protein kinase G signaling. Subsequent work on rat and mouse arteries revealed an unanticipated …
-
Expression and functional analysis of murine ryanodine receptor type 3
Ryanodine receptors (RyRs) are intracellular homotetrameric Ca<sup>2+</sup>-release channels constituting a family of three different isoforms, named RyRl, RyR2 and RyR3. RyRl and RyR2 are highly expressed in skeletal and cardiac muscles respectively, where they localize in the terminal cisternae …
-
Actin's role in signaling light-induced phase shifts in the mammalian circadian clock
… by glutamate, involves activation of NMDA receptors, nitric oxide synthesis, and opening of ryanodine receptors with subsequent influx of calcium from intracellular stores. Activation of this cascade results in up-regulation of the clock genes, Period 1 and Period 2. This induction is …
-
Pharmacological regulators of T cell calcium stores
… growth assays revealed an important role for ryanodine receptors (RyRs) in regulating T cell growth. RyR activators CMC and PCB95 dramatically altered T cell growth patterns leading to significantly reduced cell viability. In contrast RyR antagonist dantrolene appeared to induce growth arrest …
-
PHARMACOLOGICAL MODULATION OF SARCOPLASMIC RETICULUM CALCIUM ATPASE AND CALCIUM RELEASE CHANNELS FOR MUSCLE CELL PROTECTIVE ACTION
… reticulum (SR) Ca2+-ATPase (SERCA) and ryanodine receptors (RyRs). However, there are no pharmacological agents that directly and specifically target these two crucial elements required for intracellular SR Ca2+ homeostasis. Dr. Julio A. Copello’s group has previously studied the …
-
Age-associated changes to calcium handling proteins across the whole heart
… expression of L-type calcium channels (Caᵥ1.2), ryanodine receptors (RYRs), sarcoendoplasmic reticulum ATPase (SERCA), phospholamban (PLB), sodium-calcium exchangers (NCX) and plasma membrane Ca²⁺ ATPase pumps (PMCA) were analysed in the SA node, right atrium, left atrium, left ventricle and …
Page 1 of 2