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Showing 1 to 20 of 71 for “"Ryanodine"”.
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Ryanodine receptor expression in trophoblasts
… is essential in fetal skeleton formation. Ryanodine receptors (RyRs) are high conductance cation channels that mediate Ca2+ release from intracellular stores to the cytoplasm. To date, the roles of RyRs in trophoblasts have not been reported. By use of reverse transcription PCR and western …
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Ryanodine receptors in calcium signaling pathways
… of Ca<sup>2+</sup> being highly toxic.</p><p>Ryanodine receptors (RyRs) and inositol trisphosphate receptors (IP<sub>3</sub>Rs) are Ca<sup>2+</sup> -release channels located on intracellular membranes of the endoplasmic reticulum (ER)/sarcoplasmic reticulum (SR) that perform essential …
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Presenilins Modulate Cellular Activity of Ryanodine Receptors
… J., Presenilins Modulate Cellular Activity of Ryanodine Receptors. Doctor of Philosophy (Biomedical Sciences), December, 2012, 160 pp., 7 tables, 39 figures, bibliography 241 titles. Ryanodine Receptors (RyRs) are large, endoplasmic reticulum (ER) intracellular calcium channels in excitable …
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Functional separation of the biphasic actions of ryanodine
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The role of Ryanodine receptors in neuronal calcium signaling
… the internal stores. Previous studies have shown ryanodine receptors (RyRs) play a key role in the process of Ca<sup>2+</sup> signaling participating in the oscillatory patterns of controlling the release of Ca<sup>2+</sup> from ER and regulating the influx of Ca<sup>2+</sup> by coupling with …
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Modulation of neuronal ryanodine receptor-mediated calcium signaling by calsenilin
… show that calsenilin directly interacts with the ryanodine receptor (RyR) modulating Ca2+ release from this intracellular Ca2+-activated Ca2+ release channel. Co-expression, co-localization, and protein-protein interaction of calsenilin and RyR in primary neurons and in central nervous system …
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Expression and functional analysis of murine ryanodine receptor type 3
Ryanodine receptors (RyRs) are intracellular homotetrameric Ca<sup>2+</sup>-release channels constituting a family of three different isoforms, named RyRl, RyR2 and RyR3. RyRl and RyR2 are highly expressed in skeletal and cardiac muscles respectively, where they localize in the terminal cisternae …
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Role of ryanodine receptors in neuronal calcium signalling and growth control
… Ca<sup>2+</sup> influx pathway. Agonists of the ryanodine receptor (RyR); chlorom- cresol (CMC), polychlorinated biphenyl 95 (PCB), ryanodine, caffeine, and that of the inositol-1 ,4 ,5-trisphosphate receptor (IP<sub>3</sub>R), bradykinin, effectively couple to the activation of Ca<sup>2+</sup> …
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In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
… store, the Sarcoplasmic Reticulum (SR), through Ryanodine receptor Ca2+ release channels (RyRs). In the resting state, striated muscle requires a tight control of Ca2+ release through RyRs. Another SR bound protein, junctin, is thought to facilitate this. Located in both skeletal and cardiac …
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In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
… store, the Sarcoplasmic Reticulum (SR), through Ryanodine receptor Ca2+ release channels (RyRs). In the resting state, striated muscle requires a tight control of Ca2+ release through RyRs. Another SR bound protein, junctin, is thought to facilitate this. Located in both skeletal and cardiac …
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THE ROLE OF ATP AND FK-506 BINDING PROTEIN IN THE COUPLED GATING OF SKELETAL RYANODINE RECEPTORS
… sparks originate from groups of skeletal ryanodine receptors (RyR1) that activate and close in synchrony. This synchrony allows for the rapid and massive release of Ca<super>2+</super> from the sarcoplasmic reticulum to initiate contraction and, more important, would provide a mechanism to …
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Functional Importance of Oxidative Post-Translational Modifications of Ryanodine Receptor in Cardiac Sarcoplasmic Reticulum Ca2+ Handling During Oxidative Stress
… that initiates muscle contraction in the heart. Ryanodine receptor (RyR2) acts as the primary Sarcoplasmic Reticulum (SR) Ca2+ release channel in the heart. In the event that intracellular SR Ca2+ handling is compromised, both the contractility and electrical excitability of the heart can be …
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Cellular Calcium Movements and Excitation-Contraction Coupling in Guinea Pig Atria
… analysis used paired one tail T-test.) 10 nM Ryanodine treated-tissue showed an increased efflux of calcium as measured by increased para-cellular calcium concentration of 9.8 + 1.9 uM over the control condition. 8uM DCB decreased the ryanodine treated tissues calcium efflux by 53.6 + 8.0%, n …
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Cholinergic Regulation of Circadian Rhythms in the SCN: Characterization of Signaling Mechanisms and the Role of Intracellular Calcium in the Directionality of Clock Resetting
… cholinergic phase advance, while InsP3 , but not ryanodine, receptor antagonists block it. In contrast, selective activation of CICR with ryanodine results in glutamate-like delay. Ca 2+ imaging using multiphoton microscopy revealed signal-specific differences in Ca2+ transients. …
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Modulation of calcium signalling in human sperm by nitric oxide
… in human sperm, by a mechanism involving ryanodine receptor (RyR) activation. Pre-treatment with NO reduced the amplitude of the Ca\(^{2+}\) response to ryanodine (a RyR agonist), suggesting convergence of the actions of NO and ryanodine. Sperm pre-treatment with NO greatly enhanced the …
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Myocardial Contractility in Fetal Sheep Exposed to Long-term Hypoxia at High Altitude : Activator Calcium and Beta-adrenergic Receptor Function
… [Ca<sup>2+</sup>]<sub>o</sub> (0.2-10 mM), ryanodine (10<sup>-10</sup>-10<sup>-4</sup> M), isoproterenol (10<sup>-10</sup>-10<sup>-6 </sup>M), and forskolin (0.01-10 uM) in isometrically contracting papillary muscles. In addition, we quantified dihydropyridine (DHPR), ryanodine (RyR), and …
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Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
… the correction of calcium imbalance caused by ryanodine receptor malfunction. The estrogen receptor is thought to elicit this estrogenic protection by acting as a nuclear transcription factor and increasing the expression of anti-apoptotic proteins. However, the estrogen receptor also has …
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Effects of Portuguese Man-of-War (PHYSALIA PHYSALIS) Venom on Isolated Rabbit Atria
… did not significantly block the venom's effects. Ryanodine binding increases in the presence of venom showing that the venom is not in competition for calcium channels on the sarcoplasmic reticulum. These results suggest that the venom acts on the sarcolemma to increase calcium permeability, …
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