Global ETD Search
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Showing 1 to 2 of 2 for “"RxDL Motif"”.
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Functional Analysis of the Molluscum Contagiosum Virus MC160 Death Effector Domain-Containing Protein RxDL Motif
… of innate immune signaling complexes. The RxDL motif is conserved among several host and viral DED-containing proteins and has previously been shown to be required for protein function. The hypothesis of this study was the MC160 protein requires the RxDL motif to inhibit the activation of …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… factor. Mutational analysis revealed that the RxDL motif within the N-terminal DED of MC159 is required for inhibition of NF-κB. Additionally, my results show that MC159 inhibits TNF-α, PMA and MyD88 induced NF-κB activity, suggesting MC159 targets a step in the pathway shared by these …