Global ETD Search
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Showing 1 to 20 of 31 for “"Runx1"”.
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Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia
The t(12;21) translocation generates the ETV6/RUNX1 fusion gene, present in 25% of childhood acute lymphoblastic leukemia. This fusion gene is important for leukemia development but is not sufficient for leukemia to arise. Hence, the additional genetic changes present in leukemic …
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The Regulation Of Myeloid Inflammatory Responses By Runx1: Roles In Normal And Malignant Hematopoiesis
RUNX1 is frequently mutated in sporadic and inherited forms of hematologic malignancies, but the mechanism underlying it role in leukemogenesis remains poorly defined. In the first part of this work, we describe a novel role for RUNX1 in regulating TLR1/2 and TLR4 signaling and inflammatory …
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Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
… that are at risk of tumourigenic transformation. RUNX1 is a transcription factor essential for definitive hematopoiesis and is frequently targeted in human leukaemias by chromosomal rearrangements. RUNX1 has been also demonstrated to act as a dominant oncogene in mice and the ectopic expression of …
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Endometrial extracellular vesicles during pregnancy: their regulation by transcription factor RUNX1 and dysregulation by phthalate exposure
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Runx1 in Primitive Hematopoiesis and Characterization of Hematopoietic Stem Cells in a Mouse Chronic Inflammatory Arthritis Model
… regulation of primitive hematopoiesis by Runx1 and TGF-beta signaling.<underline> Primitive hematopoiesis, occurring exclusively in the yolk sac, is characterized by its transient nature. As the primitive hematopoiesis declines in the yolk sac, definitive hematopoietic progenitors …
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Heterogeneous Nuclear Ribonucleoprotein K (Hnrnp K) Overexpression and Its Interaction With Runx1 Rna In Acute Myeloid Leukemia
… RNA transcripts interacting with hnRNP K was <em>RUNX1</em>—a pivotal transcriptional regulator of definitive hematopoiesis commonly mutated or translocated in AML. Consensus hnRNP K binding sites were identified in the 5’ UTR and near the 3’ splice site in intron 5-6 of <em>RUNX1. …
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Role of transcription factor Runx1 in uterine stromal cell differentiation and maternal-fetal interaction during mouse pregnancy
… Our study revealed that the expression of Runx1, a transcription factor belonging to the runt-domain family, is markedly elevated in the uterine stromal cells during decidualization. Conditional deletion of the uterine Runx1 gene led to severe embryo growth retardation and pregnancy loss …
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Increased Microglial Reactivity Alters Morphine Analgesia
… receptor and the microglial transcription factor Runx1 in morphine analgesia and in the development of adverse effects. My over-arching hypothesis is that increased microglial reactivity diminishes the analgesic potential of opioids, such as morphine. Here I show that repeated morphine causes a …
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Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia
… It is defined by multiple copies<br/>of the RUNX1 gene, as seen by fluorescence in situ hybridisation (FISH), localised<br/>to a single abnormal duplicated chromosome 21 [dup(21)]. The morphological<br/>form of this chromosome is highly variable between patients and currently the<br/>only …
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
… erythropoiesis. We also describe here that runx1 is activated by bmp4 in an HDAC-dependent manner. Consistent with this, restoring runx1 expression partially rescues VPA mediated hematopoietic defects. We further identify that the effects of HDAC inhibition on primitive hematopoiesis is …
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Investigating clonal hematopoiesis in rhesus macaque and human
… 3. To study the competitive fitness of *RUNX1* mutant hematopoietic stem cells (HSPCs) in RM autologous transplant model. Results <br>Through error-corrected sequencing of 56 human CH/myeloid malignancy genes, we identified natural CH driver mutations in aged RMs matching genes …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… Th1 to Th17 conversion. TGF-β induction of Runx1 and RORγt, was crucial for the conversion. Taken together, my studies revealed the interference with the ERK pathway could represent a therapeutic treatment for inflammatory bowel diseases and demonstrated that Th1 cells convert into Th17 …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… Th1 to Th17 conversion. TGF-β induction of Runx1 and RORγt, was crucial for the conversion. Taken together, my studies revealed the interference with the ERK pathway could represent a therapeutic treatment for inflammatory bowel diseases and demonstrated that Th1 cells convert into Th17 …
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New methods to study human mammary development and breast cancer
… stem cell differentiation, and demonstrated that RUNX1 is required for exit from the stem/progenitor state. RUNX1 inhibition expanded the pool of stem cells and blocked mammary morphogenesis. This thesis also describes the development of a 3D hydrogel culture system that supports the growth of …
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Molecular and functional studies of ABL1 and FGFR1 fusion oncogenes in myeloproliferative neoplasms
… translocation was found to result in a truncated RUNX1 gene, suggesting that haploinsufficiency for RUNX1 could be a mechanism behind disease progression in EMS. It was also found that trisomy 21 is a common secondary change in EMS. In Article II, two variants of BCR/ABL1, P190 and P210, were …
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The role of non-genetic variability in Acute Myeloid Leukaemia
… Specifically, I analysed the biology of RUNX1RUNX1T1(9a) and Idh1R132H-initiated AML in a conditional Kat2aKO background and observed consistent acceleration of leukaemia initiation and progression with perpetuation of transformed Kat2aKO cells in vivo. Single-cell RNA sequencing …
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Understanding Gene Regulation In Development And Differentiation Using Single Cell Multi-Omics
… bottleneck separates pre-HE from HE, and RUNX1 dosage regulates the efficiency of the pre-HE to HE transition. A distal enhancer of Runx1 shows high accessibility in pre-HE cells at the bottleneck, but loses accessibility thereafter. Once cells pass the bottleneck, they follow distinct …
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Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
… neuraler Zellen spielen, wie Gata2, Runx1, Id3 und Nedd9. Die nähere Untersuchung der Auswirkungen eines Funktionsverlustes der Zielgene Ctgf, Gata2, Runx1 und Nedd9 auf die TGF-β induzierte Neurogenese identifizierte Nedd9 als notwendige Signal-Komponente während dieses Prozesses. …
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A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… haematopoietic transcription factors PU.1 and RUNX1. Interference with their binding leads to abrogation of Irf8 expression, subsequently to disturbed cell fate decisions, demonstrating the importance of these factors for proper phagocyte cell development. Collectively, these data delineate a …
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