Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Runt-related transcription factor 2 (Runx2)"”.
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The regulatory role of osteoblasts in castration-resistant growth of prostate cancer
… from patients. Further studies reveled that Runt-related transcription factor 2 (Runx2) – which is under the control of osteoblasts – is a putative regulator of de novo steroid synthesis in osteogenic CRPC cells, and this mimics a mechanism of steroid synthesis previously only described in …
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Differential expression and phenotypic activities of osterix in equine mesenchymal stem cell populations
… Osteogenesis is regulated by two master transcription factors, runt-related transcription factor 2 (RUNX2) and Osterix (OSX), with interplay from signaling pathways such as the Bone Morphogenetic Protein (BMP) network. MSCs isolated from bone marrow (BM) and adipose tissue (ADI) are most …
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Role of the RUNX2 rs59983488 variant in bone mass determination and fracture risk in Malta
Osteoporosis is a multifactorial skeletal disease which is characterised by a reduced bone density (BMD) and compromised bone microarchitecture, leading to an increased fragility fracture risk. The Runt-related Transcription Factor 2 (RUNX2) protein encoded by the RUNX2 gene is involved in the …
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On osseointegration in response to controlled surface nanotopography
… of the proinflammatory cytokine tumor necrosis factor alpha (TNF-α) and osteoclast marker cathepsin K (CatK) was downregulated at the nanopatterned implants at 3 and 6 days, respectively. This finding was consistent with fewer CD163-positive macrophages in the peri-implant tissue. Due to …
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The role of autophagy in protecting periodontium integrity, and lipopolysaccharide-induced osteoclast differentiation
… mechanical stretching resulted in enhanced Runt-related transcription factor 2 (RUNX2) expression, a marker of osteogenic differentiation. Autophagy activation is perhaps a protective mechanism as an initial response to mechanical strain, after which osteogenesis may occur. Patients …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
… of my thesis focused on studying the role of runt related transcription factor-2 (Runx2) in peripheral nerve regeneration. While the published literature and my in-silico analysis showed significant upregulation of Runx2 in Schwann cells following peripheral nerve injury, Runx2 has no …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
… The biologic behavior of cancers seems to be correlated to the state of differentiation of the tumor cell population. Differentiation is taken into account when a histopathologic grade is assigned to a particular tumor; poorly differentiated tumors acquire a higher grade and are expected to …