Global ETD Search
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Showing 1 to 5 of 5 for “"Rtt109"”.
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Experimental and computational methods for identification of novel fungal histone acetyltransferase Rtt109 inhibitors
Rtt109 is a fungal-specific histone acetyltransferase that catalyzes histone H3 lysine 56 acetylation and is a promising antifungal drug target. To identify novel Rtt109 inhibitors as potential drug scaffolds, we employed in vitro high throughput screening (HTS) and various computer-assisted …
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The influence of chromatin in DNA-RNA hybrid metabolism
… que la deleción de la acetil-transferasa Rtt109 provoca un incremento de R loops dependiente de su actividad catalítica, y gracias al análisis de distintas mutaciones en las histonas H3 y H4 hemos asociado dicho incremento con dianas concretas de entre todas las descritas para Rtt109 in …
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The structural analysis of histone H3 lysine 56 acetylation and related histone chaperone complexes
… (HAT) Regulator of Ty1 Transposition (Rtt109). The activity of Rtt109 towards H3 tail residues and H3 lysine 56 (K56) is stimulated by the histone chaperones Vacuolar Protein Sorting 75 (Vps75) and Asf1 respectively. In this study, acetylation of K56, located at the C-terminus of the H3 …
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Histone Post-translational Modification Dysregulation Contributes to Toxicity in Amyotrophic Lateral Sclerosis Proteinopathy Models
… phosphorylation at serine 10 on histone H3, and Rtt109, the histone modifying enzyme responsible for acetylation at lysine 56 on histone H3, are significantly excluded for the nucleus, while the former colocalizes with FUS. We also interrogated the binding partners of FUS by …
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Accelerated Adaptation through Stimulated Copy Number Variation in Saccharomyces cerevisiae
Accelerated Adaptation through Stimulated Copy Number Variation in Saccharomyces cerevisiae Ryan Matthew Hull Repetitive regions of the genome, such as the centromeres, telomeres and ribosomal DNA account for a large proportion of the genetic variation between individuals. Differences in the number …