Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Rrp6"”.
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Genetic Analysis of Rna Exosome Complex Cofactors
… two catalytic subunits, including Rrp44/Dis3 and Rrp6 in yeast and DIS3 or DIS3L and RRP6/EXOSC10 in humans. The RNA exosome complex plays an essential role in RNA processing and degradation, which is vital for homeostatic gene expression. Mutations that affect RNA exosome complex function lead to …
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Functional Consequences of Rna Exosome Complex Alteration By Conformational Changes and Cofactor Binding
… by its cofactors that bind substrates. Rrp6 is a ribonuclease that interacts with the RNA exosome in the nucleus. It functions not only as a nuclease but also as an adaptor protein that bridges the RNA exosome to other cofactors such as an RNA helicase, Mtr4. In this study, I found that …
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The Role of The Arched Helicases In Exosome-Mediated Function
… with the exosome-associated exonuclease, Rrp6. Further, I show that the arch domain of Ski2 is required for the degradation of normal and aberrant mRNAs.</p> <p>Additionally, this work describes in detail the Mtr4 domains involved in the physical association with other RNA processing …
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Genetic, Biochemical, and Electron Microscopic Analysis of Components Involved in Transcription Coupled mRNA Export
… THO2 and THP2 are synthetic lethal with RRP6, a component of the exosome complex, which retains and eliminates improperly 3�-end processed mRNPs, suggesting a link between transcription elongation, and RNP quality control. Finally, I analyzed the TREX complex at the biochemical level. The …
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Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases
… functional interaction’ with nuclear cofactors (Rrp6, Mpp6, and Mtr4), where one of the interactions is required for the essential function of the exosome. Thus, analyzing disease variants in the budding yeast model provides important insights into RNA exosome defects caused by patient-derived …