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Showing 1 to 4 of 4 for “"Rrp44"”.
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Functional Consequences of Rna Exosome Complex Alteration By Conformational Changes and Cofactor Binding
… nine structural cores and one catalytic subunit, Rrp44. Structural studies captured two different conformations of Rrp44, Rrp44<sup>ch</sup> (channel) and Rrp44<sup>da</sup> (direct-access). The Rrp44<sup>ch</sup> appears to recruit RNA substrates from the central channel formed by the core …
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The Role of The Arched Helicases In Exosome-Mediated Function
… only one catalytically active subunit, called Rrp44. While the same ten essential subunits make up both the nuclear and cytoplasmic exosome, there are nuclear and cytoplasmic exosome cofactors that promote specific exosome functions in each of the cell compartments. To date, it is unclear how …
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Genetic Analysis of Rna Exosome Complex Cofactors
… with one or two catalytic subunits, including Rrp44/Dis3 and Rrp6 in yeast and DIS3 or DIS3L and RRP6/EXOSC10 in humans. The RNA exosome complex plays an essential role in RNA processing and degradation, which is vital for homeostatic gene expression. Mutations that affect RNA exosome complex …
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Characterization of The Rna Binding and Rna Degrading Subunits of The Eukaryotic Exosome
<p>The exosome is an essential complex of ten proteins involved in the processing and degradation of many RNAs in the cell. These include various stable RNAs, mRNAs, and aberrant transcripts both in the nucleus and in the cytoplasm.</p> <p>In this work I characterize the three members of the …