Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Rotenone"”.
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The sterochemistry of rotenone
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1960
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Is Everything Connected? Following the Predators, Pests, and Plants Within a No-Till, Western Montana Agroecosystem
… thuringiensis var. kurstaki (Bt) and a pyrethrin/rotenone blend – this research assessed the capacity of these aforementioned predatory or parasitic arthropods to control the P. rapae population and crop damage through biological (as compared to chemical) means. Field investigations for …
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Is Everything Connected? Following the Predators, Pests, and Plants Within a No-Till, Western Montana Agroecosystem
… thuringiensis var. kurstaki (Bt) and a pyrethrin/rotenone blend – this research assessed the capacity of these aforementioned predatory or parasitic arthropods to control the P. rapae population and crop damage through biological (as compared to chemical) means. Field investigations for …
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Growth Rates of Yellow Perch, Perca Flavescens (Mitchell), in two North Dakota Lakes After Population Reduction with Toxaphene
… season. Several authors reporting the use of rotenone to thin overcrowded populations or to restore balance between fish species considered the results to be favorable. Beckman (1941) noted that the growth rates of fish surviving the treatment of one-half of Booth Lake, Michigan were too great …
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Role of metabolic stress in the selective vulnerability of dopaminergic neurons
… neurons. Here, we showed that neurotoxins rotenone and antimycin A (AA), both known inhibitors of the mitochondrial electron transport chain, promote selective dopaminergic neuronal death through mechanisms of metabolic energy decline, increased oxidative stress, and mitochondrial …
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Differential Effects of Parkinsonian Toxins and L-DOPA on Locus Coeruleus and Substantia Nigra Neurons: Implications for Parkinson’s Disease
… to environmental toxins (such as the pesticide, rotenone) has been associated with the development of PD, and rare cases have shown a causal link (MPTP/MPP+) to the disease. There is also evidence that endogenous toxins (DA-derived 6-OHDA) may be involved in disease progression. These …
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The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
… comparative studies on the mode of action of rotenone-/reserpine-/tetrabenzaine (TBZ)-induced depletion, in vitro, as these three compounds share some similarities in their chemical structures. I found that rotenone, reserpine and TBZ selectively released preloaded dopamine and serotonin …
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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
… chelator deferoxamine (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model. In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria of dopaminergic neurons, …
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… with apocynin or mitochondrial complex I with rotenone both completely suppressed ET-1-induced ROS generation and activation of ICl,swell, indicating that ROS from both NOX and mitochondria were required to activate ICl,swell, and complete block by inhibitors of either ROS source suggests …
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Investigation of Drp1 inhibition as potential therapy in pesticide-based models of Parkinson's disease
… or expression of the Drp1K38A dominant negative. Rotenone and paraquat are two pesticides implicated in the pathophysiology and progression of Parkinson’s disease, a hypokinetic neurodegenerative disorder which results in motor and cognitive changes in patients. Previous studies confirmed …
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Effects of landlocked alewife introduction on white bass and walleye populations, Claytor Lake, Virginia
… 1950 and 1971 are discussed. Based on the two rotenone samples taken during this study, the standing crop of fishes in Claytor Lake is below that of most other reservoirs.
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Effects of loigomycin, F0/F1 ATP-synthase inhibitor on mitochondrial morphology and dynamics
… effects of mitochondrial respiratory inhibitors [rotenone, TTFA (2-thenoyltrifluoro-acetone), antimycin A, and oligomycin] to investigate the complex-specific retrograde signal pathways. The inhibitors showed different effects on mitochondrial dynamics (distribution and morphology), but all …
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Mitochondrial respiratory defects induces claudin 1 expression via ROS-mediated HSF1 activation
… respiratory inhibitors, complex I inhibition by rotenone most effectively induced Cln-1 expression at transcriptional level, accompanied by increase in mitochondrial ROS production. Treatment of H2O2 directly induced Cln-1 expression, implying that Cln-1 induction was mediated by mitochondrial …
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UNDERSTADING THE ROLE OF PSEUDOKINASE TRB3 IN CANCER PROGRESSION AND CHEMORESISTANCE DURING METABOLIC STRESS
… by all stressors. One of the stressors used was rotenone, an inhibitor of the complex I of the electron transport chain. Rotenone treatment induced Trb3 expression. This expression inversely correlated with cytochrome C expression. Furthermore, Trb3 expression positively correlated with the …
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MIR-181A/B INHIBITION AS A NEW STRATEGY FOR MITOCHONDRIAL DISEASE TREATMENT
… model, two of the most prevalent MDs, and the rotenone-induced mouse model, an additional in vivo model of LHON. Notably, our results demonstrate that the downregulation of miR-181a/b consistently ameliorates various phenotypes across all tested conditions. Furthermore, the therapeutic strategy …
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Applying Flinet Deep Learning Model to Fluorescence Lifetime Imaging Microscopy for Lifetime Parameter Prediction
… SSIM values, while inhibited mitochondria (Rotenone) samples consistently show the lowest SSIM values, particularly for τ₁ and A₀, indicating reduced model reliability under these conditions.
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Interplay of Brain Derived Neurotrophic Factor and Protein Kinase A in Modulating Mitochondrial Structure and Function in Brain Homeostasis and Disease
… and oxidative stress induced by rotenone or exposure to amyloid β, in vitro models of Parkinson's and Alzheimer's disease respectively. Finally, I provide new methodology that I co-developed that allows neuroscientists to analyze neuronal metabolism and connectivity in the same …
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The Search for Novel Anthelmintic Targets: Characterizing Alternative Metabolic Pathways in Caenorhabditis elegans
… for fumarate reduction, was inhibited by rotenone. By combining statistical analyses of metabolites in animals where fumarate reduction was disrupted in different ways with a list of known RQDM enzymes, I identified twelve (12) genes which are required for RQDM, four (4) of which have …
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Differences in Fish Abundance Among Habitat Types in a Warmwater Stream; The James River, South Dakota
… efficiency was estimated for each habitat using rotenone and mark-recapture procedures. Correction factors, proportional to sampling efficiency, were used to minimize inherent sampling biases among habitats. Density (no./hectare) and biomass (kg/hectare) were calculated for three species …
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