Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Rotarod."”.
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Histological and Functional Characterization of Cervical Spinal Cord Injury After Graded Contusion
… weekly in complex horizontal ladder (cHL), rotarod, grooming, and either pellet reaching or pasta handling. Our results showed greater injury severity significantly increased missteps in cHL, reduced stepping time in rotarod, and decreased grooming ability. Histological analyses revealed …
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Surprising Behavioral and Neurochemical Enhancements in Mice with Combined Mutations Linked to Parkinson's Disease
… unexpected increase in latency to fall from the rotarod in the absence of other significant behavioral phenotypes. These results led me to examine the levels of proteins related to neurotransmitter synthesis and transport and to test non-motor behaviors in Parkin-/-DJ-1-/- mice. Behavior tests …
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Longitudinal Behavioral Assessment of Neonatal Traumatic Brain Injury
… zero maze (anxiety), forced swim (depression), rotarod (coordination and balance), and water maze (general/spatial learning). jTBI mice showed elevated activity levels, impaired sensorimotor abilities, impaired spatial learning, and less efficient spatial search strategy use compared with sham …
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Investigação da atividade psicofarmacológica do extrato etanólico bruto de Sargassum polyceratium em modelos animais utilizando roedores
… - 30 minutes). Motor c oordination, evaluated in rotarod test, has not been modified in the animals treated with SpEE in none of the doses. SpEE reduce d the time of paw licking in glutamate test, however it have not altered reaction time in hot plate test in none of the tested doses. These …
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An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice
… on motor coordination was also tested using a rotarod. The mice were put through four trials in each test over seven days post-TBI with a three day inter-trial interval between the first two trials and the last two. Results indicated that TBI did not cause anxiety or depression-like behaviors …
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The development of a novel composite score to characterize effect size of behavior and histopathology changes after a repetitive mild traumatic brain injury
… most potent behavioral tests. The Open Field and Rotarod test had a small impact on the outcome, but only in one of the three statistical models assessed. Thus, to effectively analyze treatment efficiencies, injury severity and long-term impairments, MWM and EPM are the best behavioral test for a …
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Long-Term T Cell Responses in the Ischemic Brain
… mice demonstrated better recovery in the rotarod behavior test and had fewer immune cells recruited to the brain parenchyma post-stroke. We also observed the presence of CNS-specific T cells in the post-stroke spleens and cervical lymph nodes. Taken together, these data reveal a role for …
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Identification and validation of target pathways influencing outcome after traumatic brain injury
… several behavioral I testing paradigms (Rotarod, Morris Water Maze, and Barnes Maze), we characterized spatial memory and motor function deficits resulting from TBI in order to quantify a "good" or "poor" response. Using a variety of targeted intervention strategies (CD40L knockout, …
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Therapeutic testing and epigenetic characterization of Friedreich Ataxia
… were detected on functional measurements such as rotarod performance and locomotor activity. Additionally such compounds failed to protect the brain of treated mice from oxidative insults. Therefore, the use of such antioxidant compounds cannot be advocated for FRDA therapy. Recent findings …
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Evaluating the regulation and function of adult mouse hippocampal neurogenesis induced from running
… on water maze, contextual fear conditioning, and rotarod. Groups of running and non-running mice were either irradiated to reduce neurogenesis or not irradiated. Results showed that running enhanced performance over sedentary mice on contextual fear conditioning and rotarod, regardless of …
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The Role of Microglia and Astrocyte in Spinocerebellar Ataxia Type 1
… failure to gain weight nor a prominent effect on rotarod pathology. Yet, there was a trending rescue of Kcnj10 expression in the medulla, suggesting a cell-autonomous effect of ATXN1 on astrocytic transcription. In conclusion, my thesis work concerning the role of both microglia and astrocyte in …
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Einfluss systemischer Infektionen auf den Krankheitsverlauf der Alzheimer-Erkrankung im Maus-Modell
… der Tiere wurde durch den Seiltest und den Rotarod-Test überprüft und ergab keine Defizite. Das räumliche Lernen, Lerndefizite und Erinnerungsdefizite wurden durch das Morris-Water-Maze evaluiert. Weder ein früherer Beginn noch ein schnellerer Verlauf der Alzheimer-Erkrankung konnte durch …
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Comparison of transplantation modality of human mesenchymal stem cells expressing neurogenin1 in rat middle cerebral artery occlusion model: intra-arterial vs. intra-cerebral
… showed significantly higher recovery in rotarod (p=0.003) and adhesive removal tests (p=0.046) than the animals with IC-MSCs/Ngn1. Although the IC-MSCs/Ngn1 group showed the tendency of reduction of infarct volume compared with IA-NS (normal saline) (p=0.061) and IC-NS (p=0.223) …
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The Effect of Resveratrol On Skeletal Muscle Function, Muscle Pathology, and Oxidative Capacity In the Mdx Mouse Model of Duchenne Muscular Dystrophy
… Resveratrol treatment significantly increased rotarod performance, increased specific peak tension of the triceps surae muscle complex, and reduced the rate of tension decline of the triceps surae muscle complex. Specific aim 2 examined the effect of resveratrol on muscle pathology. Muscle …
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Rate alterable traumatic brain injury device for rodent models
… tests immediately after the injury followed by rotarod, ladder rung walk, metric and spatial information, and Morris water maze tasks between 1 to 15 days post injury. Also, the perforant path-evoked granule cell field excitability is tested. Histological characterization is performed at 4h, 24 …
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Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype
… Morris water maze, non-spatial water maze, and rotarod task. Combined behavioral results from post-MCAO mice provide evidence of a RAP deficit (suggesting “aphasia-like” deficits), and deficits in learning and memory, as well as sensorimotor function. Overall results support the ongoing use of …
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Targeted Disruption of the Deaf1 Gene in Mouse Brain and the Effects on Behavior and Gene Expression
… measured in tests for depression-like behavior. Rotarod testing showed no deficits in motor skills of male mice. Learning and memory in mice were tested using Morris Water Maze (MWM) and fear conditioning. No change in long-term memory in male mice was observed in MWM, but both male and female …
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Cognitive and synaptic dysfunction in a mouse model of Huntington's disease
… mice exhibited a mild motor phenotype on the rotarod, showing hyperactivity at 2 and 3 months. Subtle changes within the hippocampus are thought to underlie the cognitive abnormalities that characterise the early stages of HD. A series of recognition tasks were used to assess the episodic …
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Experimental and Finite Element Evaluation of Mild Traumatic Brain Injury
… outcomes. Behavioral evaluations using Rotarod and Open Field tasks, along with histological markers (GFAP, Iba-1, and tau protein), demonstrated that multiple blast exposures resulted in more severe motor deficits and neuroinflammatory responses than single exposures. This highlights …
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The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
… demonstrated significant less motor deficits (by rotarod test). Histologic staining by cresyl violet stain showed significant decrease in neuronal cell death and decrease in microglia activation by either diet group. Immunohistochemical staining further showed colocalization of phospho-ERK and …
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