Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Rosiglitazone"”.
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Diabetes: The Interrelationship between Vascular, Nervous Systems and Avandia
… These studies also evaluated the effects of rosiglitazone (Avandia) on the vascular, autonomic, and somatic nervous systems.</p> <p>Fourteen diabetic subjects and fourteen control subjects (age matched) participated in three series of experiments. Using Whitney volume plesythmography to …
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Anti-diabetic properties of GUH
… to commercially available drugs metformin and rosiglitazone. Methods: Male Wistar rats were fed a maintenance diet (MD) with tap water or a high fat diet (HFD) with sucrose solution for a period of twelve weeks. Thereafter a separate groups of animals were then treated with GUH at 5 different …
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Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
… E2 and 100 nM P4). 5 ng/ml of TGF-β1, 50 nM of rosiglitazone (PPAR gamma agonist), and 20 μM of PD98059 (ERK inhibitor) were added according to experimental purposes. Trypan-blue and a hemocytometer were utilized to count the viable cell number. Enzyme-linked immunosorbent assay (ELISA) and …
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Metabolic Regulation by Fibroblast Growth Factor 21
… type and Fgf21-/- mice were treated with the TZD rosiglitazone. Rosiglitazone produced a significant increase in adipose FGF21 expression, but decreased hepatic FGF21 mRNA and circulating FGF21 protein. These data suggest that FGF21 functions as an autocrine factor within adipose tissue. Moreover, …
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Poor glycaemic control in adolescents with type 1 diabetes
… to poor glycaemic control. The effect of rosiglitazone, an insulin sensitizer, in addition to insulin on the glycaemic control of adolescents with T1DM was tested using a randomized, double blind placebo controlled trial. Treatment with rosiglitazone did not improve HbA1c, however there …
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Menopause and cardiovascular, metabolic and bone parameters
… effects of exercise, hormonal therapy (HT) and rosiglitazone on cardiovascular risk variables, glucose and insulin levels and bone turnover markers. It was hypothesised that these interventions would independentiy improve parameters measured, whilst combined treatment would provide further …
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The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes
… its closely related analogue phenformin and rosiglitazone were characterised in cultured human aortic endothelial cells (HAECs). AMPK activity was assessed using a peptide kinase assay and the quantification of phosphorylation of the AMPK substrate, acetyl-CoA carboxylase (ACC) in HAECs …
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Intracellular signalling by arachidonic acid metabolites
… (pTK-PPREx3-luc). The PPAR-γ-specific ligand, rosiglitazone, induced PPRE mediated activity in a concentration-dependent manner, while the PPAR-γ-specific irreversible inhibitor, GW9662, fully inhibited this induction. However, GW9662 only partially inhibited 15d-PGJ2-induced luciferase …
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Exploring new chemical entities from traditional medicine: Docking, synthesis and specific bioactivities
… Current clinical antidiabetic drugs, like rosiglitazone display severe side effects like edema, weight gain and heart failure. By docking the twenty-seven selected reported compounds of Goji into the partial and full agonist binding sites of PPARγ (target of rosiglitazone), tyramine …
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Development of Therapies to Treat Polycystic Kidney Disease
… the PCK rat model, and another PPARγ agonist, rosiglitazone, a 24 week study was completed using 3 doses (4, 0.4, and 0.04 mg/kg BW). 4 mg/kg BW rosiglitazone is analogous to 20 mg/kg BW pioglitazone. The data indicated that the rosiglitazone is effective in lowering the cystic burden, and …
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Impact of Glycemic Therapy on Myocardial Sympathetic Neuronal Integrity and Left Ventricular Function in Insulin Resistant Diabetic Rats: Serial Evaluation by 11C-meta-Hydroxyephedrine Positron Emission Tomography
… treated for 8 weeks with insulin, metformin or rosiglitazone, starting from either 1 week (prevention) or 8 weeks (reversal) after STZ administration. Sympathetic neuronal integrity was evaluated longitudinally by [11C]HED PET. Echocardiography measures of systolic and diastolic function were …
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Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
… The AMPK activators; sorbitol, metformin, rosiglitazone, arsenite, azide, hydrogen peroxide and isoproterenol were all shown to stimulate AMPK activity in the presence of the Ca2+/Calmodulin dependent protein kinase kinase (CaMKK) inhibitor STO-609, suggesting that these activators activate …
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Market Response to Food and Drug Administration's Safety Warnings: a Case Study Using an Interrupted Time Series Analysis of the Medicare Database for 2006-2008
… safety warning about an ongoing safety review of rosiglitazone's potential to increase cardiovascular risks on thiazolidinedione utilization rates using an interrupted time series consisting of 32 data points (13 months before and 19 months after the safety warning). Results: There was an …
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Reduced corticosteroid sensitivity in smokers with asthma: potential mechanisms and treatment
… concept clinical trial using the PPARγ agonist rosiglitazone. Treatment with rosiglitazone was associated with a trend to improvement in FEV1 and improvement in a marker of small airway lung function and as such may provide an alternative treatment for small airways obstruction in conditions …
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Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents
… the effects of AGP and the PPARγ agonist rosiglitazone (ROSI) on balloon injury-elicited neointima development. In the balloon injury model AGP significantly increased neointima; however, rosiglitazone application attenuated it. AGP and ROSI were also applied intralumenally for 1 hour …
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A Role for Microglia Activation in Modulating Behavior in a Variable Stress Model for Depression
… stress model for depression. We found that rosiglitazone, peroxisome proliferator activated receptor gamma PPAR) agonist, which causes microglial shift to an anti-inflammatory state, conferred social resilience in female mice after 6 days of variable stress. We further demonstrated that …
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Alcohol/HIV-Induced Neurodeficit and Circumvention by Neuroprotective Agent
… neuroprotective properties of PPAR γ agonist, Rosiglitazone. We investigate the efficacy of this treatment using an animal study, and further investigate the effects on receptors and cytokines. We also evaluate the type of drug effect rosiglitazone exerts in the system. In Chapter 5, we …
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PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model
… activated receptor gamma (PPARγ) agonist rosiglitazone improves hippocampus-dependent cognitive deficits in some AD patients and ameliorates deficits in the Tg2576 mouse model for AD amyloidosis. Since extracellular signal-regulated protein kinase mitogen-activated protein kinase (ERK …
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ANALYSIS OF ADULT NEUROGENESIS AND HIPPOCAMPUS-DEPENDENT MEMORY IN MOUSE MODELS FOR AGING, ALZHEIMER’S DISEASE AND CRANIAL IRRADIATION-INDUCED NEUROINFLAMMATION
… disease (AD) research is the diabetic drug, rosiglitazone which specifically binds to the nuclear receptor, peroxisome proliferating activated receptor gamma (PPAR). Inhibition of p38 activity has also been shown to be a viable therapeutic target for conserving cognition in …
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Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
… pathway in both lipotoxicity and glucotoxicity. Rosiglitazone (ROZ) effectively counteracted the deleterious effects of palmitate but not that of high glucose on the islet function. Glucose-induced expression of iNOS with subsequent β-cell dysfunction was markedly counteracted by the imidazoline …
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