Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Rolipram"”.
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Efeito relaxante de derivados N-sulfonilidrazônicos do rolipram em traqueia de cobaia : investigação do mecanismo de ação do LASSBio-1846
… were synthesized new PDE4 inhibitors from rolipram. The new N - sulfonilhidrazone derivatives had been only tested on in vitro enzymatic assa ys. To investigate their effects on physiological conditions, the guinea - pig trachea model was selected. Thus, the present study aimed to assess a …
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Phosphodiesterase 4 inhibitors for the treatment of inflammation associated with respiratory disease
… tested were SB 207499, LAS 31025, CDP 840, rolipram and RP 73401. The in vitro experiments consisted of PDE4 enzyme activity (guinea pig and human inflammatory cells) and rolipram binding activity, RBA (rat brain). The in vivo model used was the guinea pig skin model of eosinophil …
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Biochemical investigation of phosphodiesterase type IV post-translational modification, cellular localisation and interaction with associated binding proteins
… by an E3 ligase, PIASy. SUMOylation alters the rolipram sensitivity and potentiates the PKA mediated activation of the isoforms whilst it confers protection from ERK-mediated inhibition of PDE4 activity. SUMOylation alters the association of PDE4 isoforms with binding partners like β-Arrestin, …
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cAMP and Calcium Interactions in Endocrine Cells
… N-type and L-type channels and then steady CICR. Rolipram decreased the amount of [Ca<sup><sub>2+</sub></sup>]<sub>c</sub> influx compared to the control, suggesting an inhibitory effect. PDE locations within the cell dictate the level of [cAMP]<sub>c</sub> increase and the influx of …
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Der Einfluß von Steroiden und Medikamenten zur Behandlung der Multiplen Sklerose auf die LPS-induzierte iNOS/NO-Synthese in primärer Mikroglia neugeborener Ratten
… Wirkung. Die Phosphodiesterasehemmer Rolipram und Pentoxifyllin, der Matrix-Metalloproteinasen-Inhibitor BB 3103 und das Zytokin Interleukin-10 zeigten in den Untersuchungen keinen Effekt. <br>Diese Untersuchungen zeigen, dass die Hypothese, dass die Hemmung der iNOS-Synthese ein …
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Effects of Early Alcohol Exposure on Ocular Dominance Plasticity
… did not occur after treatment with a PDEi4 (rolipram) or a PDEi5 (vardenafil) inhibitor alone. Interestingly when these drugs were given concurrently, ODP was rescued. To further explore the effect of early alcohol exposure on ODP, we used Visually Evoked Potentials to examine the …
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An investigation into the synaptic conditions and celluar mechanisms underlying cerebellar synaptic plasticity
… FPs when the cAMP-specific PDE type IV inhibitor rolipram was incorporated into the perfusion medium. In summary, raised levels of PE stimulation can alter the synaptic efficacy at PF-Purkinje cell synapses. The results provide support for a role of NO/cGMP/PKG signalling in the induction of LTD …
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The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells
… and the combination of both cilostamide and rolipram (a PDE4 inhibitor) turned the proliferative effect of EGF into a differentiation effect. The route for cAMP in the regulation of the ERK pathway was decomposed by using the cAMP analogues 8-pCPT-2’-O-Me-cAMP and 6-Bnz-cAMP. They …