Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Rod photoreceptors"”.
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Controlled ablation of rod photoreceptors in transgenic Xenopus laevis
… eye. Loss of a certain group of neurons called rod photoreceptors can occur as the result of genetic mutation. In humans, and in mammalian models of retinal degeneration, the death of these cells is permanent, and often followed by cone photoreceptor death, which leads to blindness. As a step …
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The effects of the tubulin-binding drug, colchicine, on the electrophysiological aspects of phototransduction in toad rod photoreceptors
… was found to affect phototransduction in toad rods during pharmacologic screening of cytoskeletal antagonists. Colchicine superfusion onto intact retinas hyperpolarized rods, increased their membrane resistance and altered the kinetics of voltage responses to light flashes. These effects …
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Retinal development and age related degeneration following gestational lead exposure
… increase in two late-born retinal neurons: rod photoreceptors and bipolar cells. The present goals were to examine: 1) the spatiotemporal differentiation and functional development of these two cell types, 2) the profile of glutamatergic responses in developing retina prior to canonical …
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Rod Photoreceptor Regeneration in a Zebrafish Model with Retinitis Pigmentosa
… degenerative diseases is progressive loss of photoreceptors until one is completely blind. Unlike mammalian models, Zebrafish have the ability to naturally regenerate their neurons after injury or disease is detected. We have generated a zebrafish model with the most common autosomal dominant …
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Rainbow trout as a model of retinal photoreceptor death and regeneration
… reported to have a remarkable ontogeny of cone photoreceptors in their retina. The ultraviolet-sensitive (UVS) cones are of particular interest, as they disappear from, and reappear into, the retina. These events occur at times associated with migration to marine waters, and the return migration …
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Regulation of mammalian photoreceptor phosphodiesterase (PDE) by its noncatalytic GAF domains and its two small subunits, gamma and delta
… effector of visual transduction in retinal rod photoreceptors. The overall goal of this work was to investigate the possible regulatory mechanisms of PDE in mammalian rod photoreceptors by its noncatalytic cGMP binding sites on the PDE catalytic dimer (Palphabeta), and by the interactions …
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A Comprehensive Framework for Adaptive Optics Scanning Light Ophthalmoscope Image Analysis
… prognosis, and treatment of many ocular and neurodegenerative diseases, including achromatopsia (ACHM), require the visualization of microscopic structures in the eye. The development of adaptive optics ophthalmic imaging systems has made high resolution visualization of ocular microstructures …
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Effects of the OTX2ECR2 enhancer & PROX1 overexpression in murine retina development
… factor important for the development of photoreceptors and bipolar cells. If OTX2 is knocked out, photoreceptors and bipolar cells fail to differentiate. In order for OTX2 to be activated in certain retinal populations, it requires the activity of an enhancer called <em>OTX2ECR2</em>. …
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
… degeneration which starts around day 10 with rod photoreceptor cell death. By 21 days after birth virtually all rod photoreceptors in the retina have died, and subsequent cone degeneration starts. The latter process is somewhat slower and by the age of 3-4 months, the animal has practically no …
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Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
… zebrafish. In the adult light damaged retina, Neurod is not expressed in Müller glial cells as they reenter the cell cycle or their immediate progeny, but is expressed in progenitors of regenerating rod photoreceptors as they exit the cell cycle and begin differentiating. Next, we provide evidence …
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Study of the role of miR-204 in photoreceptor development
… in regulating the retina development especially photoreceptors. In particular, I focused on miR-204, one of the miRNAs our laboratory is mostly focusing on, and whose role in multiple aspects of eye development has been elucidated in the past few years from our lab and other groups. I dissected …
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Using a seed-network to query multiple large-scale gene expression datasets from the developing retina in order to identify and prioritize experimental targets
… the differentiation of retinal progenitors into photoreceptors in the developing retina is important not only due to its therapeutic applications in treating retinal degeneration but also because the developing retina provides an excellent model for studying CNS development. Although several …
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Maguk Scaffolds Organize A Key Synaptic Complex In Horizontal Cell Processes Contacting Photoreceptors
… cell processes where they contact cone and rod photoreceptors. We further identified some known SAP102 binding partners, kainate receptor GluR6/7 and inward rectifier potassium channel Kir2.1, closely associated with SAP102 in the processes of invaginating HCs. In contrast, in the mouse …
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Molecular Evolution and Functional Characterization of the Visual Pigment Proteins of the Great Bowerbird (Chlamydera nuchalis) and Other Vertebrates
… bowers. There are 4 chapters: Chapter 1 introduces background information on visual pigments and vision in birds. Among visual pigment types, the short-wavelength-sensitive (SWS1) pigments have garnered particular interest due to the broad spectral range among vertebrates and the importance …
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Regulation of the catalytic and allosteric properties of photoreceptor phosphodiesterase (PDE6) by the glutamic acid-rich protein-2 (GARP2)
… and adaptation to light stimulation in rod and cone photoreceptors. The central hypothesis of this thesis is that one PDE6 binding partner, the glutamic acid-rich protein (GARP2), may regulate PDE6 to reduce its "dark noise", enhance its sensitivity and conserve metabolic energy during …
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Regulation of rod photoreceptor phosphodiesterase (PDE6) by the glutamic acid -rich protein 2 (GARP2)
<p>Rod photoreceptor phosphodiesterase (PDE6), the central enzyme of visual transduction in vertebrate photoreceptors, associates with the disk membranes of the rod outer segment (ROS) of the photoreceptor cell. This association insures the high efficiency of activation by the G-protein, …
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Molecular Dissection of Multifunctional Proteins in Rod Outer Segments
<p>Rod photoreceptors are specialized neurons responsible for capturing photons and translating visual information into electrical signals. Visual signal transduction in rods is confined to the unique outer segment organelle, a modified primary cilium consisting of a stack of hundreds of flattened …
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New objective and psychophysical techniques to study the processing of visual signals with emphasis on chromatic afterimages
… that isolate luminance, colour or combined rod and melanopsin. Normal trichormats, rod deficient subjects, one subject with retinitis pigmentosa, one rod monochromat, three subjects with Leber’s Hereditary Optic Neuropathy (LHON) and one subject with Optic Neuritis were investigated using …
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RATE-LIMITING STEP OF CONE PHOTOTRANSDUCTION RECOVERY AND OGUCHI DISEASE MECHANISMS
… Advisor: Ching-Kang Jason Chen, Ph.D. Retinal photoreceptors provide the first gateway in which light information from the environment is transformed into neuronal signals. The cone and rod photoreceptors are responsible for day and night vision, respectively. Understanding rod and cone …
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The use of Silent Substitution in measuring isolated cone- and rod- Human ERGs
… substitution paradigm in obtaining cone- and rod- isolating ERGs using sine- and square- wave temporal profiles. The ERGs achieved in this manner were shown to be photoreceptor-selective. Furthermore, these responses did not only provide the functional index of photoreceptors but their …