Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Rnq1"”.
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Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model
… upon cell division. I used the yeast prion Rnq1 to investigate how amyloid formation contributes to proteotoxicity. Ectopic overexpression of Rnq1 was extremely toxic, but only if the endogenous Rnq1 protein had adopted its amyloid conformation. The Hsp40 co-chaperone Sis1 was able to …
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Structural Elucidation of [RNQ+] prions Transmissible Infectivity
… result from the aggregation of the proteins Rnq1 and Sup35, respectively. Changes in phenotype allows for the investigation of the structure and toxicity of yeast fibrils formed in vivo, while correlating them to what is observed in vitro.</p><p>I looked to investigate the fibril polymorphism …
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Mechanism of yeast prion portein aggregation and strain formation
… [RNQ+] and their protein determinants Sup35p and Rnq1p, respectively. Using a Sup35-PrP chimera, I have investigated the effect of the disease associated oligopeptide repeat domain: ORD) expansions of PrP, on prion propagation and amyloid fiber formation. We previously determined that these …