Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Rna-guided Endonucleases"”.
-
Methods and models of screening genomic variants
… link between genotype and phenotype. Advances in RNA-guided endonucleases have enabled such pooled screens in human cells. I first consider a model to understand drivers of immune evasion in a pooled knockout screen conducted in an in vitro model of metastatic melanoma. Next, I discuss strategies …
-
Genetic circuits for functional screens of Cas12a guide RNA libraries
The discovery of CRISPR RNA-guided endonucleases have catalyzed huge technological advancements in the field of synthetic biology, such as the creation of gene drives: genomically encoded CRISPR systems capable of spreading through a wild population. These systems have two components: a …
-
Revealing the transposable element dynamics driving evolutionary transitions through direct observation in live cells
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01