Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Rna Delivery"”.
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Impact of gaussian curvature lipids on lipid nanoparticle mediated RNA delivery
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Engineering periodic short hairpin RNA delivery systems for enhanced therapeutic efficacy
RNA interference (RNAi) presents a highly promising approach for cancer therapeutics via specific silencing of disease-implicated genes, but its clinical translation remains severely limited by barriers in delivering short interfering RNA (siRNA). Numerous delivery vehicles have been developed to …
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The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes
… the ionizable cationic lipid component, impact RNA delivery. To systematically investigate how PEG lipid chemistry impacted LNP formulation and RNA delivery, a series of linear-dendritic poly(ethylene glycol) (PEG) lipids were synthesized with modulated hydrophobic domains. The chemical …
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Design and synthesis of ionisable amino-polyester lipid nanoparticles for extrahepatic RNA delivery
Messenger RNA (mRNA)-based therapeutics represent a powerful platform with the potential to transform modern medicine by targeting diseases at their molecular origins. Advances in mRNA chemistry and delivery technologies have enabled applications ranging from vaccines and cancer immunotherapy to …
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The Design, Synthesis, and Evaluation of Zwitterionic and Cationic Lipids for In Vivo RNA Delivery and Non-Viral CRISPR/Cas Gene Editing
The delivery of nucleic acids is an emerging therapeutic modality in clinical development for the treatment of many genetic diseases. The use of RNA interference (RNAi) as a therapeutic is an exciting and rapidly developing field that offers a promising alternative to small molecule drugs for the …
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Elucidating the Impact of Endogenous Proteins on Lipid Nanoparticle Organ-Targeting Outcomes
Ribonucleic acid (RNA) biomolecules can be used for the prevention and treatment of various diseases by gene silencing, gene expression, and gene editing approaches. As RNA can be easily degraded by nucleases and does not readily cross the cell membrane to access the cytosol, where it is …
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Development of Chemically-Defined Platform Materials for Localized Delivery of RNA Therapeutics
… therapeutics have been engineered for systemic delivery with accumulation predominantly occurring in the liver. Currently, mRNA and siRNA represent the most clinically advanced nucleic acid modalities which can be used to address underlying under- or over-expression of crucial proteins, …
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Designing nanoparticles for highly efficient endothelial siRNA delivery
RNA potently regulates gene expression. However, the utility of RNA has been limited by the ability to efficiently deliver it to specific cells in vivo. In vivo RNA delivery is challenging; vehicles must avoid phagocytosis in the bloodstream, reach the target tissue, and get into, and out of, an …
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Self-Assembled Gold Nanoplexes for Cancer-Targeted siRNA Delivery
… have constructed three Au nanoplexes: AuPEI/RNA/PEI, AuPEI/RNA/PEI-mPEG, and AuPEI/NA/PEI-PEG-FA. All the nanoplexes are characterized by UV-vis spectrometry, DLS, and zeta potential. The surface density of the first layer PEI and second layer RNA were also determined. Moreover, the Au …
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Programmable biomolecular integration and dynamic behavior of DNA-based systems for development of biomedical nano-devices
… nanofactory capable of production of therapeutic RNA to overcome the challenges in RNA delivery. Moreover, we established a mechanism to drive DNA devices by changing temperature with prolonged dynamic behavior that was previously challenging to accomplish without special modification of DNA …
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Uptake of Small EVs by Skeletal Muscle Myoblasts In Vitro and Subsequent Myogenic Response to Cargo
… manner, with muscle-specific microRNAs (myomiRs) playing a central role in regulating the balance between myoblast proliferation and differentiation. Among these, miR-206 is a key regulator. Despite its therapeutic potential, miR-206 application is limited by RNA instability and …
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Controlled local delivery of RNA : regulating tissue morphogenesis
RNA interference (RNAi) is a powerful technology that provides a means to alter the expression of a specific protein based on a targeted RNA sequence. This is done by taking advantage of existing cellular machinery present within all eukaryotic cells which use short double-stranded RNA sequences as …
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Entwicklung neuartiger bakterieller Vektoren zur Übertragung von zellassoziierten Antigenen, DNA und RNA auf der Basis virulenzattenuierter L. monocytogenes
… Herkunft über das LPXTG-Ankermotiv von Internalin A. Die so erzielte starke Expression in der Zellwand setzte aber sowohl die Fitness der Bakterien als auch deren Invasivität in vitro deutlich herab und verhinderte damit eine effektive MHC-I-Präsentation des verwendeten Modellantigens. …
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Discovery of IKBKE and CD24 siRNAs for the treatment of triple-negative breast cancer
… with resistance to therapies. Small interfering RNA (siRNA) can specifically knockdown the expression of target genes. It represents a promising tool for cancer therapy as it can silence aberrant genes that are essential for the progression of cancer cells. However, successful siRNA cancer …