Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Ripk3"”.
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Rôle de RIPK3 dans la mort induite par la thérapie photodynamique
La protéine RIPK3 (Receptor-interacting protein 3) a été montrée comme étant un activateur clé de la nécrose, mais il a également été constaté qu’il pouvait induire l’apoptose. L’objectif de cette étude est de comparer le profil de la mort induite par la thérapie photodynamique (PDT) médiée par …
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Exploring the oligomeric state of TLR4 and downstream regulators RIPK1 and RIPK3
… Key regulators in the TLR4 pathway are RIPK1 and RIPK3, which are essential during programmed cell death, and therefore, signalling via TLR4 is key in the decision between pro immunity or cell death during infection. Whilst much is known about which molecules are involved in TLR4 signalling, the …
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The Role of CK1 in Necroptosis and Confirmation of Amyloid-Like Fibers in Necroptosis Using 2D SDD-AGE
… protein kinase 1 and 3 (RIPK1, RIPK3) and mixed-lineage kinase domain-like protein (MLKL). Phosphorylation of human RIPK3 at serine 227 (S227) has been shown to be required for downstream MLKL binding and necroptosis progression. Tandem immunoprecipitation of RIPK3 reveals that …
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Apoptosis and Necroptosis in Renal Cell Carcinoma // Апоптоза и некроптоза при бъбречноклетъчен карцином
… necroptosis. A key participant in the process is RIPK3, which is known to have both tumor-stimulating and tumor-suppressive functions in different tumors. Further in-depth studies are needed on the role of RIPK3 in tumour development, progression, metastases, and recurrence, as well as anti-tumour …
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Apoptosis and Necroptosis in Basal Cell and Spinocellular Carcinoma of the Skin // Апоптоза и некроптоза при базоцелуларен и спиноцелуларен карцином на кожа
… has features of both apoptosis and necrosis. RIPK3 is a major necrotic protein in various types of neoplasms. In the process of eliminating and destroying tumour cells, the mechanisms and pathways of different types of cell death can be involved in complex interactions. Therapeutic approaches …
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The role of Dietary Interventions in Broiler Intestinal Health and Immunity
… Receptor interacting serine/threonine kinase 3 (RIPK3) expression was significantly decreased upon MRF-1 supplementation in the duodenum, jejunum and caecum. Supplementation of mannan rich fraction 3 (MRF-3) significantly enhanced protein expression levels of p-Akt. MRF-2 and MRF-3 dietary …
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Characterisation of Novel Autophagy and Necroptosis Antagonists Encoded by Human Cytomegalovirus
… of receptor-interacting protein kinase 3 (RIPK3). A systematic screen of HCMV recombinants lacking blocks of accessory genes dispensable for viral replication indicated that deleting either the US18–US22 or UL13–UL20 gene blocks significantly increases necroptosis in infected cells. Further …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
Receptor-interacting protein kinase 3 (RIP3 or RIPK3) is a central player in “programmed” or “regulated” necrotic cell death pathway. Here we show that programmed necrosis is activated in response to chemotherapeutic agents and contributes to chemotherapy-induced breast cancer cell death. However, …
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The Role of Necroptosis in Inflammatory Bowel Disease // Ролята на некроптозата при възпалителните чревни заболявания
… нивото на експресия на маркера за некроптоза – RIPK3 в чревната лигавица и връзката му с клинико-патологичните показатели при пациенти с възпалителни чревни заболявания.
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Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
… serine/threonine-protein kinase 3 (RIPK3) in the cell death signalling pathway (Chapter-II). For the first time we report that IFN-γ and IFN-γ + TNF-α induced JAK1/2-STAT1 signalling followed a dose-to-duration pattern of activation whereby increasing concentration of cytokines …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… proteins for PINK1 were identified, including RIPK3, calmodulin, EGFR, and interferon regulatory genes, all of which have been implicated in PD and as components of the Akt signalling system. Accumulation of α-synuclein is central to the development of PD, and mutations in SNCA, which encodes …
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Optogenetic control of necroptosis pathway
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Influenza A Virus Induced Programmed Cell Death
Influenza A viruses (IAV) are negative sense RNA viruses that naturally infect a wide variety of animals. Different subtypes of the virus infect waterfowl, poultry, pigs, horses, ferrets, bats, dogs, cats and humans, causing zoonotic outbreaks and pandemics. In humans, IAV strains cause seasonal …