Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Rigidity sensing"”.
-
Dynamics of Cellular Rigidity Sensing on the Micron and Sub-micron Scale
… mechanical parameters such as geometry and rigidity of the substrate are controlled independently and forces exerted by cells were measured. The experimental system for this study is based on fabrication of micron and submicron pillar substrates and their surface functionalization and …
-
Rheology and Collective Behavior in Living Tissue
… couples a structural order parameter for tissue rigidity to cell polarization. Using this continuum model we identify a new mechanism for pattern formation in confluent tissues via rigidity sensing that we name “morphotaxis”. We find that a single “morphotactic” parameter controls whether a …
-
Integrin-Linked Kinase, ECM Composition, and Substrate Rigidity Regulate Focal Adhesion - Actin Coupling, Modulating Survival, Proliferation and Migration: Towards a Biophysical Cancer Biomarker
… force generation, motility events and the rigidity response, also regulates the amount of biochemical signaling towards survival, growth and proliferation. First, via a knockout cell line system I demonstrate that Integrin-Linked Kinase is involved in coupling Beta1 integrins to collagen …
-
Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… of mechanotransduction, using cytoskeleton-based rigidity-sensing mechanisms between themselves and their environment, and as a consequence, their inherent stiffness is regulated by the rigidity of their environment. No considerable difference of cell fluidity was found between cell phenotypes (CF …
-
VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… how extracellular matrix (ECM) proteins and rigidity regulate the force-induced signaling pathway. In pathological situations like pulmonary fibrosis, the change of ECM can affect the endothelium permeability in response to mechanical perturbations. In this chapter, I showed that ECM proteins …